A5077121542- Crystallization and Solubility Studies
- Invertebrate Immune Response Mechanisms
- X-ray Diffraction in Crystallography
- Neurobiology and Insect Physiology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Listeria monocytogenes in Food Safety
- Metal-Organic Frameworks: Synthesis and Applications
- Metal complexes synthesis and properties
- Nonlinear Dynamics and Pattern Formation
- Biosimilars and Bioanalytical Methods
- Protein purification and stability
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- Complex Systems and Time Series Analysis
- Rheumatoid Arthritis Research and Therapies
- Antifungal resistance and susceptibility
- Trace Elements in Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Research on Leishmaniasis Studies
- Nanoparticles: synthesis and applications
- Aquaculture disease management and microbiota
- Immunotherapy and Immune Responses
- COVID-19 and Mental Health
- Medical Device Sterilization and Disinfection
- Chaos control and synchronization
Roche (United Kingdom)
2021-2024
The Francis Crick Institute
2016-2021
Novartis (Switzerland)
2014-2017
University Hospital of Basel
2009-2010
University of Fribourg
2010
Prosthetic joint replacements are used increasingly to alleviate pain and improve mobility of the progressively older more obese population. Implant infection occurs in about 5% patients entails significant morbidity high social costs. It is most often caused by staphylococci, which introduced perioperatively. They a source prolonged seeding difficult treat due antibiotic resistance; therefore, prevention prosthesis coating with nonantibiotic-type anti-infective substances indicated. A...
Trials of tocilizumab in patients with severe COVID-19 pneumonia have demonstrated mixed results, and the role combination other treatments is uncertain. Here we evaluated whether plus remdesivir provides greater benefit than alone pneumonia. This randomized, double-blind, placebo-controlled, multicenter trial included hospitalized requiring > 6 L/min supplemental oxygen. Patients were randomly assigned (2:1 ratio) to receive 8 mg/kg or placebo intravenously ≤ 10 days remdesivir. The primary...
Cross-presentation of antigens from dead tumor cells by type 1 conventional dendritic (cDC1s) is thought to underlie priming anti-cancer CD8
ABSTRACT Brominated furanones from marine algae inhibit multicellular behaviors of gram-negative bacteria such as biofilm formation and quorum sensing (QS) without affecting their growth. The interaction furanone with QS in gram-positive is unknown. Staphylococci have two systems, agr luxS , which lower by different pathways, RNAIII upregulation bacterial detachment, polysaccharide intercellular adhesin (PIA) reduction, respectively. We synthesized natural compound 2 [(5 Z...
Abstract Objective To investigate the safety and efficacy of subcutaneous tocilizumab (SC-TCZ) treatment in a long-term extension (LTE) clinical trials polyarticular or systemic juvenile idiopathic arthritis (pJIA sJIA). Methods Patients with pJIA sJIA from two open-label, 52-week phase 1b core SC-TCZ who had adequate response per investigator assessment entered LTE continued according to body weight–based dosing regimens until commercial availability up 5 years. Pharmacokinetics,...
Damage-associated molecular patterns (DAMPs) are molecules released by dead cells that trigger sterile inflammation and, in vertebrates, adaptive immunity. Actin is a DAMP detected mammals the receptor, DNGR-1, expressed dendritic (DCs). DNGR-1 phosphorylated Src-family kinases and recruits tyrosine kinase Syk to promote DC cross-presentation of cell-associated antigens. Here we report actin also invertebrates lack DCs Administration Drosophila melanogaster triggers response characterised...
Varying the polyethyleneglycol spacer between two (iso)-nicotinic groups of ligand systems, a large structural variety silver coordination compounds was obtained, starting with zero-dimensional ring via one-dimensional chains, helices and double-helices to two-dimensional polycatenanes. Theoretical calculations help understand their formation allow predictions in some cases. These structures can be tuned by careful design ligand, use solvent counter ions, influencing also other important...
Damage-associated molecular patterns (DAMPs) are molecules exposed or released by dead cells that trigger modulate immunity and tissue repair. In vertebrates, the cytoskeletal component F-actin is a DAMP specifically recognised DNGR-1, an innate immune receptor. Previously we suggested actin also in
Observational studies have identified the potential prognostic value for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) viral load and anti-SARS-CoV-2 antibodies in coronavirus disease 2019 (COVID-19). However, nasopharyngeal (NP) swabs produced inconsistent results analyses, of or has not been confirmed large clinical trials. COVACTA REMDACTA were double-blind, randomized, controlled trials with a combined enrollment 1078 patients hospitalized COVID-19 treated tocilizumab...
Environmental monitoring represents an integral part of the microbiological quality control system a pharmaceutical manufacturing operation. However, guidance documents differ regarding recommendation procedure, particularly incubation time, temperature, or nutrient media. Because these discrepancies, many manufacturers decide for particular environmental sample strategy and support this decision with validation data. Such validations are typically laboratory-based in vitro studies, meaning...
This article reports the validation strategy used to demonstrate that Milliflex<sup>®</sup> Quantum yielded non-inferior results traditional bioburden method. It was validated according USP <1223>, European Pharmacopoeia 5.1.6, and Parenteral Drug Association Technical Report No. 33 comprised parameters <i>robustness, ruggedness, repeatability, specificity, limit of detection quantification, accuracy, precision, linearity, range,</i> <i>equivalence in routine operation.</i> For...
Abstract Review: 34 refs.
A previous analysis of fluctuations in a virtuoso (Jeff Porcaro) drum performance [R\"as\"anen et al., PLoS ONE 10(6): e0127902 (2015)] demonstrated that the rhythmic signal comprised both long range correlations and short anti-correlations, with characteristic timescale distinguishing two regimes. We have extended R\"as\"anen al.'s approach to much larger number samples (N=132, provided by total 58 participants) different (viz., Rush's Tom Sawyer). key focus our study was test whether...