A5000385063- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Ovarian cancer diagnosis and treatment
- Per- and polyfluoroalkyl substances research
- Endometrial and Cervical Cancer Treatments
- Carcinogens and Genotoxicity Assessment
- Pesticide Exposure and Toxicity
- Sarcoma Diagnosis and Treatment
- Microplastics and Plastic Pollution
- Uterine Myomas and Treatments
- Cervical Cancer and HPV Research
- Neonatal Respiratory Health Research
- Atmospheric chemistry and aerosols
- Health, Environment, Cognitive Aging
- Mesenchymal stem cell research
- Environmental Toxicology and Ecotoxicology
- Testicular diseases and treatments
- Mercury impact and mitigation studies
- Prenatal Screening and Diagnostics
- Parvovirus B19 Infection Studies
- Metabolomics and Mass Spectrometry Studies
- Folate and B Vitamins Research
- Ureteral procedures and complications
- Sulfur Compounds in Biology
Research Center for Eco-Environmental Sciences
2020-2025
University of Chinese Academy of Sciences
2020-2025
Chinese Academy of Sciences
2020-2025
West China Second University Hospital of Sichuan University
2006-2024
Sichuan University
2007-2024
Brigham and Women's Hospital
2019-2021
Dalian University of Technology
2016-2020
Although organophosphate diester (di-OPE) metabolites in urine are usually used to assess human exposure esters (OPEs), whether they can reflect all OPEs with great differences chemical structures and properties is still currently unclear. In this study, we detected sixteen ten di-OPEs 52 paired whole blood, serum, samples collected Beijing, China investigate the correlations between different compounds matrices, thus providing proper biomarkers of OPEs. The order median concentrations ∑OPEs...
Organophosphorus flame retardants (OPFRs) have been increasingly used in various building and decoration materials to fulfill fire safety standards since the phasing out of polybrominated diphenyl ethers. We determined OPFR concentrations most commonly available local markets online China. The varied significantly, from 14.78 ng/g (putty powder) 9649000 (expanded polystyrene panel (EPS)). Relatively high OPFRs were found foam samples, followed by nonwoven polyvinyl chloride (PVC) wallpaper,...
Human exposure to OPEs is pervasive and should be of great concern due associations with adverse health effects, especially in susceptible populations. In this study, body burdens pathways were investigated for 76 healthy elderly people Jinan, China based on the measured OPE metabolite concentrations human bio-samples (whole blood urine) paired environmental matrices (air dust), as well food frequency questionnaire. Eight 16 5 11 metabolites detected > 50% whole urine samples, respectively....
Background: Organophosphate esters (OPEs) are common endocrine-disrupting chemicals, and OPE exposure may be associated with type 2 diabetes (T2D). However, greater knowledge regarding the biomolecular intermediators underlying impact of OPEs on T2D in humans needed to understand biological etiology. Objectives: We explored associations between glycometabolic markers among older Chinese adults 60–69 years age elucidate mechanisms using a multi-omics approach. Methods: This was longitudinal...
Sodium p-perfluorous nonenoxybenzenesulfonate (OBS), a novel alternative to perfluorooctane sulfonic acid (PFOS), has been widely used in various fields China and certain toxic effects similar PFOS. This study monitored OBS 15 legacy PFASs surface water, sediment, soil, crucian carp near fluorochemical manufacturing factory (FMF) Suqian, China, focusing on the emission, isomer-specific environmental fate, transformation of OBS. One four orders magnitude higher concentrations than other...
The penetration of organophosphate triesters (tri-OPEs) and diesters (di-OPEs) across the blood–brain barrier their influencing factors remain unclear in humans. In this study, 21 tri-OPEs 8 di-OPEs were measured 288 paired serum cerebrospinal fluid (CSF) samples collected Jinan, China. Six frequently detected both CSF, with median concentrations ranging from 0.062 to 1.62 0.042–1.11 ng/mL, respectively. Their efficiencies blood–CSF (BCSFB) (RCSF/serum, CCSF/Cserum) calculated at 0.667–2.80,...
Human exposure to per- and polyfluoroalkyl substances (PFASs) has gained worldwide attention due their widespread presence in the environment adverse health effects, but assessment elderly is still lacking. This study aimed assess exposures 3 emerging PFASs (chlorinated ether sulfonic acids, Cl-PFESAs) 15 legacy PFASs. The temporal variability of internal intake amounts these were evaluated among a population 76 healthy adults (age: 60-69) Jinan, China over 5 consecutive months. Fifteen...
Studies on dietary exposure to organophosphate esters (OPEs) and diesters (di-OPEs) are limited, especially regarding di-OPEs their presence in raw grains, which fundamental staples of the human diet. In this study, 18 OPEs 8 were measured 289 grain samples from 13 major grain-producing regions China belonging four types: wheat, rice, maize, soybean. TCIPP TEHP dominant OPEs, while BEHP was main di-OPE. The highest concentrations both ∑OPEs ∑di-OPEs observed soybean (median: 14.9 1.87 ng/g,...
Studies on dietary exposure to organophosphate esters (OPEs) and diesters (di-OPEs) are limited, especially regarding di-OPEs their presence in raw grains, which fundamental staples of the human diet. In this study, 18 OPEs 8 were measured 289 grain samples from 13 major grain-producing regions China belonging four types: wheat, rice, maize, soybean. Tris(2-chloroisopropyl) phosphate (TCIPP) tris(2-ethylhexyl) (TEHP) dominant OPEs, while bis(2-ethylhexyl) (BEHP) was main di-OPE. The highest...
Little is known about the presence of organophosphate esters (OPEs) in drinking water from dispensers, which are popular China. In this study, 22 OPEs were measured barreled (BW), normal-temperature (NTW), and hot (HW) collected 53 dispensers. Eight frequently detected, with total concentrations (median) increasing by 23- 52-fold NTW HW, respectively, compared BW. Six exhibited significantly higher levels HW than The gradually increased several after it had been stored plastic tanks, coupled...
Measurement of organophosphate esters (OPEs) in human body fluids is important for understanding internal exposure to OPEs and assessing related health risks. Most the current studies have focused on determination OPE metabolites urine, as are readily metabolized into their diester or hydroxylated forms body. However, given existence one metabolite across multiple OPE, well low metabolic rates several vitro studies, reliability urinary biomarkers specific needs be treated with caution.Human...
Primary perivascular epithelioid cell tumors (PEComas) of the female reproductive tract have been primarily reported as case reports owing to their clinical rarity. Limited incidence rates and data hinder a comprehensive understanding risks invasiveness this disease. We discuss herein diagnosis, treatment, prognosis disease enhance comprehension therapeutic strategies.