A5103225112- Prostate Cancer Treatment and Research
- Protein Degradation and Inhibitors
- Multiple Myeloma Research and Treatments
- Cell Image Analysis Techniques
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- bioluminescence and chemiluminescence research
- Liver Disease and Transplantation
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
- Retinal Development and Disorders
- RNA and protein synthesis mechanisms
- Hydrogels: synthesis, properties, applications
- Vascular Anomalies and Treatments
- Motor Control and Adaptation
- Emergency and Acute Care Studies
- Advanced Drug Delivery Systems
- Cardiovascular Issues in Pregnancy
- Cancer, Lipids, and Metabolism
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Gestational Diabetes Research and Management
- Pulmonary Hypertension Research and Treatments
- Radiology practices and education
University of Massachusetts Chan Medical School
2024-2025
Maharaja Sayajirao University of Baroda
2024
National Institute of Pharmaceutical Education and Research
2024
Government of India
2024
Texas A&M University
2023
Bay Medical Center
2022
Rowan University
2022
Rutgers, The State University of New Jersey
2000-2021
Dartmouth Institute for Health Policy and Clinical Practice
2020
Boston Medical Center
2020
Single-cell RNA-seq's (scRNA-seq) unprecedented cellular resolution at a genome-wide scale enables us to address questions about heterogeneity that are inaccessible using methods average over bulk tissue extracts. However, scRNA-seq data sets also present additional challenges such as high transcript dropout rates, stochastic transcription events, and complex population substructures. Here, we s ingle-cell RNA-seq nalysis k lustering e valuation (SAKE), robust method for analysis provides...
Resistance to androgen receptor (AR) antagonists is a significant problem in the treatment of castration-resistant prostate cancers (CRPC). Identification mechanisms by which CRPCs evade deprivation therapies (ADT) critical develop novel therapeutics. We uncovered that rely on BRD4-HOXB13 epigenetic reprogramming for androgen-independent cell proliferation. Mechanistically, BRD4, member BET bromodomain family, epigenetically promotes HOXB13 expression. Consistently, genetic disruption or...
The incidence of alcohol-associated hepatitis (AH) is rising in women reproductive age. While the adverse effects alcohol on pregnancy are well documented, there limited data with a history AH. This study was completed by using TriNetX Research Network. primary objectives were to evaluate and related complications pregnancies following an episode AH (AH pregnancies) compared healthy patients (control pregnancies). secondary objective assess long-term liver-related mortality who experienced...
Abstract HOXB13, a homeodomain transcription factor, is linked to recurrence following radical prostatectomy. While HOXB13 regulates Androgen Receptor (AR) functions in context dependent manner, its critical effectors prostate cancer (PC) metastasis remain largely unknown. To identify transcriptional targets metastatic PCs, we performed integrative bioinformatics analysis of differentially expressed genes (DEGs) the proximity human tumor-specific AR binding sites. Unsupervised Principal...
Abstract A series of glucose‐based degradable superabsorbent hydrogels with potential to tackle issues associated sustainability, flooding, and drought has been designed fabricated. These hydrophilic networks were constructed through integrating glucose as a primary building block –into cyclic oligomers polymers, which combined into mechanically‐interlocked slide‐ring crosslinked materials. Crosslinking slide ring α‐cyclodextrin/poly(ethylene glycol)‐type polyrotaxanes acid‐functionalized...
A case of aneurysm the pulmonary artery in a young pregnant woman is described.In addition, she had persistent ductus arteriosus and congenital right ventricular infundibular muscular stenosis.At necropsy wall showed lesions medionecrosis.Death occurred relation to evacuation bowels.Presumably increased intrathoracic pressure caused final rupture aneurysm, which probably already dissected extensively.Aneurysms are rare may affect main or one major branches.An association with has been noted...
MicroRNAs (miRNAs) are small 21-22 nt RNAs that act to regulate the expression of mRNA target genes through direct binding targets. While miRNAs typically dominate RNA (sRNA) transcriptomes, many other classes present including tRNAs, snoRNAs, snRNAs, Y-RNAs, piRNAs, and siRNAs. Interactions between processing machinery targeting networks these various sRNA remains unclear, largely because sRNAs analyzed separately. Here, we TEsmall, a tool allows for simultaneous analysis from each...
Overall survival (OS) in patients with multiple myeloma (MM) varies across racial and ethnic groups [1]. Prior to the early 2000s, black were shown have a advantage over white ...
Abstract Single-cell RNA-Seq’s (scRNA-Seq) unprecedented cellular resolution at a genome wide scale enables us to address questions about heterogeneity that are inaccessible using methods average over bulk tissue extracts. However, scRNA-Seq datasets also present additional challenges such as high transcript dropout rates, stochastic transcription events, and complex population substructures. Here, we SAKE (Single-cell RNA-Seq Analysis Klustering Evaluation): robust method for analysis...
Certain types of leukemia are amongst the first neoplasias to be “cured” with relatively high 5-year remission rates. This is largely due targeted therapeutics. However, considerable resistance tumor-specific targeting drugs has developed presence abundant cancer stem cells, profound genetic diversity, redundant growth/survival pathways and residual disease. Although these issues propose a challenge, they also provide opportunity for novel innovations therapy which currently include...
Meckel's diverticulum (MD) is one of the most common congenital abnormalities gastrointestinal tract, affecting approximately two percent population. Rarely, diverticula have been found to harbor various tumors, which go unnoticed until later in their course. The clinical presentation varies among each individual, and tumors often metastasized or caused diverticular rupture at time diagnosis. This a case 55-year-old male with past medical history alcohol abuse asthma who presented emergency...
College students are at risk for making poor dietary choices that can cause significant health problems. Adescriptive study was conducted to assess the effect of food consumption pattern on status amongnursing Dinsha Patel Nursing, Nadiad. A sample 101students selected bysystematic random sampling technique. Five point Likert Scale used consumptionpattern. The data analyzed by using descriptive and inferential statistics. result present studyreveals 50(49%) have more than 11 g/dl hemoglobin...
Many computational pipelines exist for the detection of differentially expressed genes. However, functional gene rarely exist. We developed a new pipeline identification from transcriptome profiling data. Key features include batch effect correction, clustering optimization by gap statistics, ontology analysis clustered genes, and literature discovery. By leveraging this on RNA-seq datasets two mouse retinal development studies, we identified 7 candidate genes involved in formation...
<p>Supplementary Fig. 1. Epigenetic landscape and the transcription cofactor recruitment at HOXB13 enhancer region under various treatments; Supplementary Figure 2. BRD4 is a target of dual BET-kinase inhibitors in CRPCs; 3. Sensitivity normal AR negative cell lines to novel inhibitors; 4. but not FOXA1 epigenetic control prostate cancer cells; S5. Haploinsufficiency sensitizes CRPCs S6. AURKB expression correlates with human CTCs from mCRPC patients following Abiraterone therapy; S7....
<div>Abstract<p>Resistance to androgen receptor (AR) antagonists is a significant problem in the treatment of castration-resistant prostate cancers (CRPC). Identification mechanisms by which CRPCs evade deprivation therapies (ADT) critical develop novel therapeutics. We uncovered that rely on BRD4-HOXB13 epigenetic reprogramming for androgen-independent cell proliferation. Mechanistically, BRD4, member BET bromodomain family, epigenetically promotes HOXB13 expression....
<p>Supplementary Fig. 1. Epigenetic landscape and the transcription cofactor recruitment at HOXB13 enhancer region under various treatments; Supplementary Figure 2. BRD4 is a target of dual BET-kinase inhibitors in CRPCs; 3. Sensitivity normal AR negative cell lines to novel inhibitors; 4. but not FOXA1 epigenetic control prostate cancer cells; S5. Haploinsufficiency sensitizes CRPCs S6. AURKB expression correlates with human CTCs from mCRPC patients following Abiraterone therapy; S7....