A5043104745- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Synthesis and biological activity
- melanin and skin pigmentation
- Advanced Battery Materials and Technologies
- Synthesis and Characterization of Heterocyclic Compounds
- Biochemical Analysis and Sensing Techniques
- Phytochemicals and Antioxidant Activities
- Advanced Battery Technologies Research
- Advancements in Battery Materials
- Viral Infections and Immunology Research
- Chemistry and Chemical Engineering
- Housing Market and Economics
- X-ray Diffraction in Crystallography
- CRISPR and Genetic Engineering
- Natural product bioactivities and synthesis
- Islamic Finance and Banking Studies
- Microbial Applications in Construction Materials
- Crystallization and Solubility Studies
- Bioactive Compounds and Antitumor Agents
- Diverse Scientific Research Studies
- Chemical synthesis and alkaloids
- Banking stability, regulation, efficiency
- Cytomegalovirus and herpesvirus research
University of Gujrat
2017-2022
Sustainable Development Policy Institute
2021
In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines (
To explore new scaffolds as tyrosinase enzyme inhibitors remain an interesting goal in the drug discovery and development. In due course our approach to synthesize bioactive compounds, a series of varyingly substituted 3-hydroxyflavone derivatives (1-23) were synthesized one-pot reaction screened for vitro against mushroom enzyme. The structures newly compounds unambiguously corroborated by usual spectroscopic techniques (FTIR, UV-Vis, 1H-, 13C-NMR) mass spectrometry (EI-MS). structure...
The COVID-19 pandemic has claimed more than a million lives worldwide within short time span. Due to the unavailability of specific antiviral drugs or vaccine, infections are causing panic both in general public and among healthcare providers. Therefore, an urgent discovery development effective drug for treatment is highly desired. Targeting main protease (Mpro) causative agent, SARS-CoV-2 great potential repurposing efforts. Published crystal structures Mpro further facilitated silico...
In this protocol, a series of 3-benzyloxyflavone derivatives have been designed, synthesized, characterized and investigated in vitro as cholinesterase inhibitors. The findings showed that all the synthesized target compounds (1-10) are potent dual inhibitors acetylcholinesterase (AChE) butyrylcholinesterase (BChE) enzymes with varying IC50 values. comparison, they more active against AChE than BChE. Remarkably, amongst series, compound 2 was identified most inhibitor both (IC50 = 0.05 ±...
Introduction: Azo-compounds, with the general formula R-N=N-R' (where R and R' can be either aryl or alkyl groups), constitute an important class of organic dyes. Over past decades, these compounds have attained increasing attention scientific community because their immense biological as well industrial applications. Keywords: 4-Aminophenol, 4-methoxyaniline, azo-compounds, antibacterial activities, DFT calculations, computational approach.
This study aims to assess what determines/improves the overall multidimensional nature of financial development index and its sub-indices. For this purpose, we use data over period 1998 2017 for 9 countries from Asia-Pacific region. The hypothesis no long run relationship between variables is tested via three-panel co-integration test i.e. Kao test, Pedroni Johansen test. We also examine impact these on each through long-run dynamic estimation. utilize FMOLS DOLS purpose. All tests suggest a...