A5051040794- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Health Systems, Economic Evaluations, Quality of Life
- Mental Health Research Topics
- Tryptophan and brain disorders
- COVID-19 and Mental Health
- Adolescent and Pediatric Healthcare
- Obsessive-Compulsive Spectrum Disorders
- Mental Health Treatment and Access
- Electrolyte and hormonal disorders
- Mental Health and Psychiatry
- Long-Term Effects of COVID-19
- COVID-19 and healthcare impacts
- Intensive Care Unit Cognitive Disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Neurotransmitter Receptor Influence on Behavior
- Child and Adolescent Psychosocial and Emotional Development
- Opioid Use Disorder Treatment
- Pharmaceutical studies and practices
- Genetics and Neurodevelopmental Disorders
- Telemedicine and Telehealth Implementation
- Psychedelics and Drug Studies
- Meta-analysis and systematic reviews
Harvard University
2018-2025
Boston University
2024
McLean Hospital
2021
Massachusetts General Hospital
2021
University of Buenos Aires
2016-2021
Brigham and Women's Hospital
2021
Favaloro University
2015-2020
Neurosciences Institute
2020
Kaiser Permanente
2017
Hospital Italiano de Buenos Aires
2017
There is an increasing use of ayahuasca for recreational purposes. Furthermore, there a growing evidence the antidepressant properties its components. However, are no reports on effects this substance in psychiatric setting. Harmaline, one main components ayahuasca, selective and reversible MAO-A inhibitor serotonin reuptake inhibitor.We present case man with bipolar disorder who had manic episode after consumption ritual. This patient at least hypomanic past currently depressed. We discuss...
Sustained melatonin supplement use may delay pubertal onset, but evidence is limited. In the Adolescent Brain Cognitive Development study, we assessed if for 38 months affected timing of onset in males (N=3,134) and menarche females (N=4,424). Pubertal outcomes were parent-reported using Scale. We emulated sequential target trials to evaluate effect initiating continuing use. Findings contrasted with comparisons ever- never-users initiators non-initiators Cox models. sequentially 1,037,709...
To evaluate the impact of COVID-19 pandemic on clinical outcomes, we used data from Electronic Health Records 128 patients receiving care at a First Episode Psychosis clinic.Rates admission or emergency room (ER) visits January 2020 to July were analysed using difference-in-difference regression. We same weeks in 2019 control for seasonality.We found 17 hospitalizations ER between 1 and 13 March (incidence rate: 71.4 events/1000 person-weeks) 6 14 20 June 18.5 an incidence rate ratio 0.26....
Objective: The Z-drugs (zolpidem, zopiclone, zaleplon) are widely used to treat insomnia in patients receiving prescription opioids, and the risk of overdose resulting from this coprescription has not been explored. authors compared rates among using opioids plus alone. Methods: All individuals 15 85 years age regardless underlying indication without evidence cancer, were identified IBM MarketScan database (2004–2017). Patients with concomitant exposure matched 1:1 alone based on opioid...
Behavioral and emotional adverse events induced by drugs commonly prescribed to patients with bipolar disorders are of paramount importance clinical practice research. However, no reviews on the topic have been published so far. An extensive search was performed. Reports were reviewed if they described behavioral side effects related pharmacological treatments for in healthy subjects or different neuropsychiatric disorders. For this review, lithium, antipsychotics, anticonvulsants selective...
Abstract Good adherence to antipsychotic therapy helps prevent relapses in first-episode psychosis (FEP). We used data from the FEP-CAUSAL Collaboration, an international consortium of observational cohorts, emulate a target trial comparing antipsychotics, with treatment discontinuation as primary outcome. Other outcomes included all-cause hospitalization. benchmarked our results estimates European First Episode Schizophrenia Trial, randomized conducted 2000s. 1097 patients psychotic...
Chronic treatment with antipsychotics may result in both metabolic side effects and cardiovascular disease. Our aim was to evaluate the effect of antipsychotic medications categorized by their profiles as low, intermediate, or high risk on major events.A retrospective cohort study conducted adult outpatients aged 30 years older initiating from 2002 2007. Antipsychotic were divided into 3 groups (low-, intermediate-, high-risk) according severity side-effect developing abnormalities...
Background In recent years, growing interest in the neuropsychology of bipolar disorder has emerged, giving rise to accumulation a robust body evidence on this topic and several related questions. Objective To provide state-of-the-art overview neuropsychological profile disorder. Method A thorough literature search was performed. Published research summarized organized along three key pathways: findings from cross-sectional studies cognition patients, cognitive heterogeneity among affected...
The US FDA issued a black-box warning against co-prescription of antipsychotic (AP) agents and opioids due to the risk respiratory depression, but evidence on comparative safety sedating vs nonsedating APs is lacking. We classified as (eg, quetiapine, olanzapine, chlorpromazine) aripiprazole, haloperidol, risperidone) based their affinity histamine-1 neuroreceptor (Ki < or ≥20, respectively) sought compare rate overdose between patients using plus opioids. constructed population-based cohort...