A5056002687- Skin and Cellular Biology Research
- Wound Healing and Treatments
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Polysaccharides Composition and Applications
- Electrospun Nanofibers in Biomedical Applications
- Dermatology and Skin Diseases
- Toxic Organic Pollutants Impact
- Epigenetics and DNA Methylation
- Carcinogens and Genotoxicity Assessment
- Cervical Cancer and HPV Research
- Pharmacogenetics and Drug Metabolism
- Estrogen and related hormone effects
- Reproductive tract infections research
- Cancer-related Molecular Pathways
- Drug-Induced Hepatotoxicity and Protection
- Nutrition, Genetics, and Disease
- RNA modifications and cancer
- Plant Toxicity and Pharmacological Properties
- Curcumin's Biomedical Applications
- FOXO transcription factor regulation
- Surgical Sutures and Adhesives
- Skin Protection and Aging
- Drug Transport and Resistance Mechanisms
- Ubiquitin and proteasome pathways
Universidad Nacional Autónoma de México
2016-2025
Universidad Autónoma de la Ciudad de México
2019-2024
Hospital Juárez de México
2012-2016
Instituto Politécnico Nacional
2016
Center for Research and Advanced Studies of the National Polytechnic Institute
2007-2010
Centro de Investigación en Materiales Avanzados
2008
Human skin possesses an essential function in the maintenance of individuals' health. However, it may undergo a variety lesions that produce wounds distinct severity. In this respect, instantly after any wound, process tissue regeneration and repair initiates. Nevertheless, diverse factors can delay process, including bacterial infections, nutritional status, age, hypoxia, chronic diseases, necrosis, vascular arterial diseases. Thus, wound dressings are frequently used to improve healing....
Controlled release is of vital relevance for many drugs; thus, there a keen interest in materials that can improve the profiles formulations administered via buccal, transdermal, ophthalmic, vaginal, and nasal. The desirable effects those include improvement stability, adhesiveness, solubility, retention time. Hence, different synthetic natural polymers are utilized to achieve these objectives. In this respect, xanthan gum an anionic polysaccharide be obtained from Xanthomonas bacteria. It...
Non-biodegradable materials with a low swelling capacity and which are opaque occlusive the main problems associated clinical performance of some commercially available wound dressings. In this work, novel biodegradable dressing was developed by means alginate membrane polycaprolactone nanoparticles loaded curcumin for potential use in healing. Curcumin employed as model drug due to its important properties healing, including antimicrobial, antifungal, anti-inflammatory effects. To determine...
Abstract Icaritin is a natural prenylated flavonoid derived from the Chinese herb Epimedium. The compound has shown antitumor effects in various cancers, especially hepatocellular carcinoma (HCC). exerts its anticancer activity by modulating multiple signaling pathways, such as IL‐6/JAK/STAT3, ER‐α36, and NF‐κB, affecting tumor microenvironment immune system. Several clinical trials have evaluated safety efficacy of icaritin advanced HCC patients with poor prognoses, who are unsuitable for...
Cancer treatment typically involves multiple strategies, such as surgery, radiotherapy, and chemotherapy, to remove tumors. However, chemotherapy often causes side effects, there is a constant search for new drugs alleviate them. Natural compounds are promising alternative this problem. Indole-3-carbinol (I3C) natural antioxidant agent that has been studied potential cancer treatment. I3C an agonist of the aryl hydrocarbon receptor (AhR), transcription factor plays role in expression genes...
Extracellular vesicles (EVs) mediate many stages of tumor progression including angiogenesis, escape from immune surveillance, and extracellular matrix degradation. We studied whether EVs plasma women with breast cancer are able to induce an epithelial-mesenchymal transition (EMT) process in mammary epithelial cells MCF10A. Our findings demonstrate that patients a downregulation E-cadherin expression increase vimentin N-cadherin expression. Moreover, migration invasion, as well NFκB-DNA...
Levels of enzymes that determine testosterone catabolism such as CYP3A4 have been associated with prostate cancer (PCa) risk. Although some studies related CYP3A4*1B allele, a gene polymorphism modifies expression level, PCa risk, others failed, suggesting additional genetic variants may be involved. Expression is largely due to the activation Pregnane X Receptor (PXR). Particularly, rs2472677 and rs7643645 PXR polymorphisms modify levels. To evaluate whether PXR-HNF3β/T (rs2472677),...