A5078007567- Respiratory Support and Mechanisms
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- Complement system in diseases
- Neonatal and Maternal Infections
- Pleural and Pulmonary Diseases
- Hemodynamic Monitoring and Therapy
- COVID-19 diagnosis using AI
- SARS-CoV-2 and COVID-19 Research
Universitätsmedizin Göttingen
2022-2023
University of Göttingen
2022-2023
University of Cambridge
2020
Addenbrooke's Hospital
2020
Rationale: In the ECMO to Rescue Lung Injury in Severe ARDS (EOLIA) trial, oxygenation was similar between intervention and conventional groups, while minute ventilation reduced group. Comparable reductions intensity are theoretically possible with low-flow extracorporeal CO2 removal (ECCO2R), provided that remains acceptable. Objectives: To compare effects of ECCO2R membrane (ECMO) on gas exchange, respiratory mechanics hemodynamics animal models pulmonary (intratracheal HCl)...
Critical illness is accompanied by the release of large amounts anaphylotoxin, C5a. C5a suppresses antimicrobial functions neutrophils which associated with adverse outcomes. The signaling pathways that mediate C5a-induced neutrophil dysfunction are incompletely understood. Healthy donor exposed to purified demonstrated a prolonged defect (7 hours) in phagocytosis Staphylococcus aureus. Phosphoproteomic profiling 2712 phosphoproteins identified persistent and selective impairment phagosomal...
Rationale: Weaning from venovenous extracorporeal membrane oxygenation (VV-ECMO) is based on and not carbon dioxide elimination. Objectives: To predict readiness to wean VV-ECMO. Methods: In this multicenter study of mechanically ventilated adults with severe acute respiratory distress syndrome receiving VV-ECMO, we investigated a variable CO2 The included prospective interventional physiological cohort (n = 26) retrospective clinical 638). Measurements Main Results: failure in the cohorts...
The amount of energy delivered to the respiratory system is recognized as a cause ventilator-induced lung injury (VILI). How dissipation within parenchyma causes damage still matter debate. Expiratory flow control has been proposed strategy reduce dissipated into during expiration and, possibly, VILI. We studied 22 healthy pigs (29 ± 2 kg), which were randomized (n = 11) and valve group 11), where expiratory was controlled through variable resistor. Both groups ventilated with same tidal...
Abstract Historical background The prone position was first proposed on theoretical in 1974 (more advantageous distribution of mechanical ventilation). clinical report 5 ARDS patients 1976 showed remarkable improvement oxygenation after pronation. Pathophysiology findings CT scans enhanced the use patients. main mechanism improved gas exchange seen is nowadays attributed to a dorsal ventilatory recruitment, with substantially unchanged perfusion. Regardless exchange, primary effect more...
Abstract Background To evaluate the differences in clinical characteristics and severity of lung impairment, assessed by quantitative CT scan, between vaccinated non-vaccinated hospitalized patients with COVID-19; to identify variables best prognostic prediction according SARS-CoV-2 vaccination status. We recorded clinical, laboratory scan data 684 consecutive [580 (84.8%) vaccinated, 104 (15.2%) non-vaccinated], admitted January December 2021. Results Vaccinated were significantly older 78...
Abstract Critical illness is accompanied by the release of large amounts anaphylotoxin, C5a. C5a suppresses antimicrobial functions neutrophils which associated with adverse outcomes. The signalling pathways that mediate C5a-induced neutrophil dysfunction are incompletely understood. Healthy donor exposed to purified demonstrated a prolonged defect (7 hours) in phagocytosis Staphylococcus aureus . Phosphoproteomic profiling 2712 phosphoproteins identified persistent and selective impairment...