A5012824258- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- Circadian rhythm and melatonin
- Psychological Well-being and Life Satisfaction
- Advanced biosensing and bioanalysis techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Occupational and environmental lung diseases
- Cardiomyopathy and Myosin Studies
- Protein Tyrosine Phosphatases
- Health, psychology, and well-being
- Muscle Physiology and Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Autophagy in Disease and Therapy
- Healthcare professionals’ stress and burnout
- Nuclear Structure and Function
- RNA Interference and Gene Delivery
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Cellular transport and secretion
- Adipose Tissue and Metabolism
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Extracellular vesicles in disease
WinnMed
2025
Mayo Clinic
2019-2024
Mayo Clinic in Arizona
2022-2023
Mayo Clinic in Florida
2023
Produced by senescent cells, the senescence-associated secretory phenotype (SASP) is a potential driver of age-related dysfunction. We tested whether circulating concentrations SASP proteins reflect age and medical risk in humans. first screened endothelial fibroblasts, preadipocytes, epithelial myoblasts to identify candidates for human profiling. then associations between clinical data from individuals throughout life span older adults undergoing surgery prevalent but distinct diseases. A...
Cellular senescence is an irreversible form of cell-cycle arrest caused by excessive stress or damage. While various biomarkers cellular have been proposed, there are currently no universal, stand-alone indicators this condition. The field largely relies on the combined detection multiple to differentiate senescent cells from non-senescent cells. Here we introduce a new approach: unbiased cell culture selections identify cell-specific folded DNA aptamers vast libraries trillions random...
Cellular senescence is a cell fate in response to diverse forms of age-related damage and stress that has been implicated the pathogenesis idiopathic pulmonary fibrosis (IPF). The associations between circulating levels candidate biomarkers disease outcomes have not specifically studied IPF. In this study we assessed individuals affected by IPF controls evaluated their ability predict outcomes.We measured plasma concentrations 32 proteins associated with Lung Tissue Research Consortium...
Aging | doi:10.18632/aging.205112. Sarah K. Jachim, Jian Zhong, Tamas Ordog, Jeong-Heon Lee, Aditya V. Bhagwate, Nagaswaroop Kengunte Nagaraj, Jennifer J. Westendorf, João F. Passos, Aleksey Matveyenko, Nathan LeBrasseur
ABSTRACT His domain protein tyrosine phosphatase (HD-PTP; also known as PTPN23) facilitates function of the endosomal sorting complexes required for transport (ESCRTs) during multivesicular body (MVB) formation. To uncover its role in physiological homeostasis, embryonic lethality caused by a complete lack HD-PTP was bypassed through generation hypomorphic mice expressing reduced protein, resulting animals that are viable into adulthood. These exhibited marked lipodystrophy and decreased...
Abstract Cellular senescence is a state of stable growth arrest in response to stress, which fundamental process biological aging. They secrete products, the Senescence-Associated Secretory Phenotype (SASP), consists inflammatory cytokines, chemokines, factors and matrix remodeling proteins. Senescent cells accumulate with advancing age partial elimination senescent can reverse age-related dysfunction increase mean lifespan mice. However, it not clear whether components SASP be measured...
Abstract Endosomal Sorting Complexes Required for Transport (ESCRTs) drive reverse topology membrane remodeling events including the formation of intralumenal vesicles within multivesicular bodies, budding retroviruses from plasma membrane, and scission cytokinetic bridge. It has been difficult to study physiological relevance this machinery in mammals because many contributing components are essential viability. To bypass problem we used combinations knockout (−), hypomorphic (H) wildtype...