A5085646978- Autoimmune and Inflammatory Disorders Research
- Growth Hormone and Insulin-like Growth Factors
- Sexual Differentiation and Disorders
- Adolescent and Pediatric Healthcare
- Cardiovascular Syncope and Autonomic Disorders
- Rheumatoid Arthritis Research and Therapies
- Diabetes and associated disorders
- Acute Lymphoblastic Leukemia research
- Heart Rate Variability and Autonomic Control
- Diabetes Management and Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cardiovascular Function and Risk Factors
- Birth, Development, and Health
- Cardiovascular Health and Disease Prevention
- Hip disorders and treatments
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Neuroscience of respiration and sleep
- Connective tissue disorders research
- Cardiac electrophysiology and arrhythmias
- Spondyloarthritis Studies and Treatments
- Heart rate and cardiovascular health
- Bone health and osteoporosis research
- Transplantation: Methods and Outcomes
- Muscle Physiology and Disorders
Ludwig-Maximilians-Universität München
2002-2022
LMU Klinikum
2006-2022
München Klinik
2007-2020
Universitätskinderklinik
1997-2014
Children's Clinical University Hospital
2003-2014
University Children's Hospital Tübingen
2001-2014
Boston Children's Hospital
2003-2013
Universitäts-Kinderklinik Würzburg
2007
German Center for Pediatric and Adolescent Rheumatology
2001-2003
Uniwersytecki Szpital Dziecięcy
2003
Context: Normal to decreased final height (FH) has been reported in patients with congenital adrenal hyperplasia (CAH).
Cardiovascular disease due to atherosclerosis is a major cause of morbidity and mortality in adult diabetic patients. In children, signs subclinical such as increased intima-media thickness (IMT) the common carotid arteries have been detected several studies. However, concerns may arise about different analyzing methods used because measurements patients controls differ significantly.We studied 208 children [150 with diabetes mellitus type 1, mean age (+/-sd) 13.9 +/- 2.8 yr, 66 males,...
Decreased bone mineral density has been reported in children with inflammatory bowel disease (IBD). We used peripheral quantitative computed tomography (pQCT) to assess mineralization, geometry, and muscle cross-sectional area (CSA) pediatric IBD.In a study, pQCT of the forearm was applied 143 IBD patients (mean age 13.9 +/- 3.5 years); 29% were newly diagnosed, 98 had Crohn's disease, 45 ulcerative colitis. Auxological data, cumulative glucocorticoid dose, activity indices, laboratory...
Type 1 diabetes mellitus is a generally accepted atherogenic risk factor. The aim of this prospective longitudinal study was to evaluate changes in carotid intima media thickness (cIMT) children and adolescents with type (T1DM) using standardized methods.We re-evaluated cIMT 70 (38 f) initial 150 (80 patients T1DM after 4 years. At re-evaluation, mean (±SD) age 16.45±2.59 y, duration 9.2±3.24 y had HbA1c 8.14±1.06%.Mean z-scores increased significantly during years (0.58±0.75, p<0.001) as...
Cystinosis is an autosomal recessive storage disease due to impaired transport of cystine out lysosomes. Since the accumulation intracellular affects all organs and tissues, management cystinosis requires a specialized multidisciplinary team consisting pediatricians, nephrologists, nutritionists, ophthalmologists, endocrinologists, neurologists' geneticists, orthopedic surgeons. Treatment with cysteamine can delay or prevent most clinical manifestations cystinosis, except renal Fanconi...
Turner syndrome (TS) is associated with multiple skeletal abnormalities. Fracture incidence appears to be increased, but the reasons for this are not entirely clear. In present study, we used peripheral quantitative computed tomography evaluate bone mass, density, geometry, and strength of radial metaphysis diaphysis as well maximum forearm muscle cross-sectional area (CSA) in a group 21 TS patients. These individuals were 19.5 +/- 2.3 yr age (mean SD; range, 16.2-25.4 yr) had completed...
Normal to severely decreased bone mineral density has been reported in children with type 1 diabetes. To detect possible abnormalities mineralization, geometry, and muscle unit, we measured selective parameters diabetes using peripheral quantitative computed tomography.Measurements of the radius by tomography were made assess cortical trabecular characteristics as well mass 88 patients (42 girls, 46 boys) at a mean age 11.7 +/- 3.0 years, disease duration 5.6 3.7 manifestation 6.1 3.5 years....
The aim of this study was to establish whether type 1 diabetes has a long-term effect on bone development in children and adolescents.Bone characteristics muscle cross-sectional area (CSA) were analyzed cross-sectionally 41 (19 female 22 male) patients reevaluated after 5.56 +/- 0.4 years using peripheral quantitative computed tomography (pQCT). We hypothesize that size mass normalize with age.At the first evaluation, mean SD age 9.87 2.3 disease duration 4.31 2.9 years. Height -0.36 1.9 SD,...
GH treatment stimulates growth in short children with juvenile idiopathic arthritis (JIA). The extent to which this therapy increases final height is not known.Thirty-one growth-retarded systemic and polyarticular were enrolled controlled study. After a mean observational time of 8.4 yr, was reached 13 patients (seven females six males) treated for 6.7 yr dose 0.33 mg/kg body weight per week. Eighteen (12 served as an untreated control group.Mean increment the group 1.6 +/- 0.8 SD, whereas...
OBJECTIVE Type 1 diabetes and multiple sclerosis (MS) are typical autoimmune diseases in children young adults. We assessed the co-occurrence of type MS by estimating relative risk (RR) for a pediatric adolescent diabetic population looked possible influencing factors. RESEARCH DESIGN AND METHODS Within Diabetes Patienten Verlaufsdokumentation (DPV)-Wiss Project, from January 1995 to October 2012, data 56,653 patients with were collected 248 centers Germany Austria. Published on German...
Osteopenia and growth retardation have been described in children with chronic arthritis. GH has an impact on both. In the present controlled study, we used peripheral quantitative computed tomography to evaluate forearm bone mass, density, geometry as well muscle fat area 17 patients juvenile idiopathic arthritis (JIA) receiving treatment for 3.8 +/- 1.1 yr compared untreated age- sex-matched control group (n = 17). All had a mean age of 15.3 2.5 duration illness 8.2 4.4 yr. Height, weight,...
Disturbance of growth frequently occurs in children suffering from juvenile chronic arthritis (JCA). Recognition impairment is important because reduced final height one the permanent consequences. The aim this study was to evaluate efficacy and safety human GH (hGH) growth-retarded prepubertal with JCA. Thirty-five were tested for deficiency (GHD) randomly assigned a an untreated control group; five deficient part GHD group. All received glucocorticoids. group treated 1 IU/kg BW·wk hGH;...
GH has a positive impact on growth, bone, and muscle development. The objectives of this study were to demonstrate the effects treatment regional body composition bone geometry at final height in patients with juvenile idiopathic arthritis (JIA).In longitudinal study, parameters mineral density as well fat cross-sectional area (CSA) nondominant forearm recorded using peripheral quantitative computed tomography yearly intervals until 12 (seven females) receiving treatment. Data compared 13...
Retesting of patients with childhood-onset growth hormone deficiency (CO-GHD) is recommended after completion (GH) treatment.To identify who are at risk persistent GHD, and to evaluate the most reliable cut-off level for GH secretion using insulin tolerance test (ITT) in transition from childhood adulthood.Ninety (22 female) CO-GHD were retested ITT 1.1 +/- years discontinuation therapy. Fifty-eight 77 (75%) initially diagnosed idiopathic GHD showed normalization secretion. Thirteen multiple...
Dalla Pozza R, Netz H, Schwarz HP, Bechtold S. Subclinical atherosclerosis in diabetic children: results of a longitudinal study. Context: Cardiovascular disease caused by is major cause morbidity and mortality adult patients. In children, we detected signs subclinical large patient cohort. This study reports the observation this group. Patients methods: Of 37/150 children whom an increased intima-media thickness (IMT) carotid artery had been found, 27 (mean age 14.6 ± 2.6 yrs) could be...