A5066801954- Pharmacological Effects and Toxicity Studies
- Neurological Complications and Syndromes
- HIV/AIDS drug development and treatment
- Bone health and osteoporosis research
- Hormonal and reproductive studies
- Genetics and Neurodevelopmental Disorders
- Lipoproteins and Cardiovascular Health
- Epilepsy research and treatment
Tecnológico Nacional de México
2018
Instituto Politécnico Nacional
2017-2018
Epilepsy is a neurological disorder that can produce brain injury and neuronal death. Several factors such as oxidative stress have been implicated in epileptogenesis. Valproic acid (VPA) widely used drug for the treatment of epilepsy, but mechanisms underlying these benefits are complex still not fully understood. The objective this study was to evaluate, first time, effects VPA on oxidant‐antioxidant status Mexican epileptic children before after 6 or 12 months with by determining...
Epilepsy is a neuronal disease that affects up to 70 million people worldwide. The development of effective therapies combat childhood epilepsy requires early biomarkers. Here, we performed whole-genome microarray analysis in blood cells identify genes differentially expressed between epileptic and valproic acid (VPA)-treated children versus normal obtain information about the gene expression help us understand genetic aspects this disease. We found most significant were related...