The sophistication of proteomic analysis has revealed that protein lysine residues are posttranslationally modified by a variety acyl groups. Protein acetylation regulates metabolism, gene expression, and microtubule formation been extensively studied; however, the understanding biological significance other posttranslational modifications (PTMs) is still in its infancy. acylation mediated either acyltransferase "writer" enzymes or nonenzymatic mechanisms hydrolase enzymes, termed "erasers",...

Zinc oxide has been developed as a catalyst for the dehydrogenation of primary alcohols into carboxylic acids and hydrogen gas. The reaction is performed in mesitylene solution presence potassium hydroxide, followed by workup with hydrochloric acid. transformation can be applied to both benzylic aliphatic catalytically active species was shown homogeneous compound hot filtration test. Dialkylzinc strongly basic zinc salts also catalyze similar results. mechanism believed involve formation...

Abstract Quorum sensing (QS) is a mechanism that regulates group behavior in bacteria, and Gram-positive the communication molecules are often cyclic peptides, called autoinducing peptides (AIPs). We recently showed pentameric thiolactone-containing AIPs from Listeria monocytogenes , other species, spontaneously undergo rapid rearrangement to homodetic cyclopeptides, which hampers our ability study activity of these short-lived compounds. Here, we developed chemically modified analogues...

Group behavior in many bacteria relies on chemically induced communication called quorum sensing (QS), which plays important roles the regulation of colonization, biofilm formation, and virulence. In Gram-positive bacteria, QS is often mediated by cyclic ribosomally synthesized posttranslationally modified peptides (RiPPs). staphylococci, for example, most these so-called autoinducing (AIPs) contain a conserved thiolactone functionality, has also been predicted to constitute structural...

The iron(III) salen complex (R,R)-N,N'-bis(salicylidene)-1,2-cyclohexanediamineiron(III) chloride has been developed as a catalyst for the acceptorless dehydrogenation of alcohols. catalyzes direct synthesis imines in good yields from different primary alcohols and amines with liberation hydrogen gas. mechanism investigated experimentally labelled substrates theoretically density functional theory calculations. In contrast to corresponding manganese(III) salen-catalyzed dehydrogenation, it...

Abstract Quorum sensing (QS) is a mechanism that regulates group behavior in bacteria, and Gram-positive the communication molecules are often cyclic peptides, called autoinducing peptides (AIPs). We recently showed pentameric thiolactone-containing AIPs from Listeria monocytogenes , other species, spontaneously undergo rapid rearrangement to homodetic cyclopeptides, which hampers our ability study activity of these short-lived compounds. Here, we developed chemically modified analogues...

The sophistication of proteomic analysis has revealed that protein lysine residues are posttranslationally modified by a variety acyl groups. Protein acetylation regulates metabolism, gene expression, and microtubule formation been extensively studied; however, the understanding biological significance other posttranslational modifications (PTMs) is still in its infancy. acylation either mediated acyltransferase ‘writer’ enzymes or through non-enzymatic mechanisms hydrolase enzymes, termed...

Group behavior in many bacteria relies on chemically induced communication called quorum sensing (QS), which plays important roles regulation of colonization, biofilm formation, and virulence. In Gram-positive bacteria, QS is often mediated by cyclic ribosomally synthesized posttranslationally modified peptides (RiPPs). staphylococci for example, most these so-called autoinducing (AIPs) contain a conserved thiolactone functionality, has been predicted to constitute structural feature AIPs...

Group behavior in many bacteria relies on chemically induced communication called quorum sensing (QS), which plays important roles regulation of colonization, biofilm formation, and virulence. In Gram-positive bacteria, QS is often mediated by cyclic ribosomally synthesized posttranslationally modified peptides (RiPPs). staphylococci for example, most these so-called autoinducing (AIPs) contain a conserved thiolactone functionality, has been predicted to constitute structural feature AIPs...