A5019623714- Cancer, Stress, Anesthesia, and Immune Response
- Intensive Care Unit Cognitive Disorders
- Cancer, Hypoxia, and Metabolism
- Cancer Cells and Metastasis
- Anesthesia and Neurotoxicity Research
- Neuroinflammation and Neurodegeneration Mechanisms
First Affiliated Hospital of Jinan University
2022
Surgery-induced microglial activation is critical in mediating postoperative cognitive dysfunction (POCD) elderly patients, where the important protective effect of dexmedetomidine has been indicated. However, mechanisms action during neuroinflammatory response that underlies POCD remain largely unknown. We found lipopolysaccharide (LPS) induced substantial inflammatory responses primary and BV2 cells. The screening differentially expressed miRNAs revealed miR-103a-3p was downregulated these...
Colorectal cancer (CRC) is one of the most frequently diagnosed gastrointestinal malignancies worldwide and has high rates morbidity mortality. Propofol been reported to have certain anticancer properties. However, role mechanism propofol in CRC are not entirely clear. cells were treated with and/or LDH-overexpression plasmids, a mouse xenograft model was also established propofol. Cell viability, migration, invasion evaluated by CCK-8, wound healing, transwell assays; expression related...