A5045727310- Trace Elements in Health
- Antimicrobial Peptides and Activities
- Receptor Mechanisms and Signaling
- Mass Spectrometry Techniques and Applications
- Molecular Sensors and Ion Detection
- Iron Metabolism and Disorders
- Neuroendocrine regulation and behavior
- Vitamin D Research Studies
- Metal-Catalyzed Oxygenation Mechanisms
- Neuropeptides and Animal Physiology
- Biopolymer Synthesis and Applications
- Biotin and Related Studies
- RNA modifications and cancer
- Metal complexes synthesis and properties
University of California, Irvine
2024
University of California, Davis
2018-2023
Oxytocin is a 9-amino acid peptide hormone. Since its discovery in 1954, it has most commonly been studied relation to role stimulating parturition and lactation. However, now known that oxytocin widely diverse set of functions throughout the body including neuromodulation, bone growth, inflammation. Previous research suggested divalent metal ions may be required for activity, but exact species specific pathways have yet fully elucidated. In this work, we focus on characterizing copper zinc...
The connecting peptide (C-peptide) has received increased attention for its potential therapeutic effects in ameliorating illnesses such as kidney disease and diabetes. Although the mechanism of C-peptide signaling remains elusive, evidence supports internalization intracellular function. Emerging research is uncovering diverse biological roles metals play controlling affecting function bioactive peptides. work presented herein investigates interactions between first-row d-block transition...
Recent studies have revealed critical roles for the local environments surrounding metallocofactors, such as newly identified Cu
The proinsulin connecting peptide, C-peptide, is released in equimolar amounts and might be an active hormone. exact function of C-peptide remains unclear, but its activity depend on metal ions. As depicted this cover art, bioavailable metals could the missing piece to elucidate C-peptide′s activity. More information can found communication by M. C. Heffern et al. page 2447 Issue 19, 2019 (DOI: 10.1002/cbic.201900172).