A5000319405- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Hemodynamic Monitoring and Therapy
- Congenital Heart Disease Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological disorders and treatments
- Infant Health and Development
- Infant Development and Preterm Care
- Reproductive System and Pregnancy
- Pediatric Pain Management Techniques
- Ultrasound and Hyperthermia Applications
- Cardiovascular Conditions and Treatments
- MicroRNA in disease regulation
- Congenital Anomalies and Fetal Surgery
- Congenital Diaphragmatic Hernia Studies
- Anesthesia and Neurotoxicity Research
- Cardiovascular Syncope and Autonomic Disorders
University College London
2022-2024
Hospital for Sick Children
2021-2024
Great Ormond Street Hospital
2022-2024
University of Toronto
2021-2024
SickKids Foundation
2021-2024
Abstract Objectives Neonatal hypoxic-ischemic encephalopathy is a serious neurologic condition associated with death or neurodevelopmental impairments. Magnetic resonance imaging (MRI) routinely used for neuroprognostication, but there substantial subjectivity and uncertainty about outcome prediction. We sought to develop an objective automated approach the analysis of newborn brain MRI improve accuracy prognostication. Methods created anatomical template from sample 286 infants treated...
Abstract Congenital diaphragmatic hernia (CDH) is a devastating condition characterized by incomplete closure of the diaphragm and herniation abdominal organs into chest. As result, fetuses have pulmonary hypoplasia, whose severity main determinant poor outcome. The pathogenesis hypoplasia secondary to CDH at least in part explained lack or dysregulation miRNAs that are known regulate lung developmental processes. Herein, we report intra-amniotic administration extracellular vesicles derived...
Abstract Pregnancy is associated with extraordinary plasticity in the maternal brain. Studies humans and other mammals suggest extensive structural functional remodeling of female brain during after pregnancy. However, we understand remarkably little about molecular underpinnings this natural phenomenon. To gain insight into pregnancy-associated hippocampal plasticity, performed single nucleus RNA sequencing (snRNA-seq) snATAC-seq from mouse hippocampus before, during, We identified cell...