A5074194445- Optical Coherence Tomography Applications
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Photoacoustic and Ultrasonic Imaging
- Advanced Fluorescence Microscopy Techniques
- Optical Imaging and Spectroscopy Techniques
- Ion Transport and Channel Regulation
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Mitochondrial Function and Pathology
- Epilepsy research and treatment
- Ion channel regulation and function
- Toxoplasma gondii Research Studies
- Autophagy in Disease and Therapy
- ATP Synthase and ATPases Research
- Epigenetics and DNA Methylation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- FOXO transcription factor regulation
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Electrolyte and hormonal disorders
- Atherosclerosis and Cardiovascular Diseases
- Neurogenesis and neuroplasticity mechanisms
University of California, Riverside
2012-2023
University of California, Irvine
2020-2023
Saint John's Health Center
2021-2023
The immune privileged nature of the CNS can make it vulnerable to chronic and latent infections. Little is known about effects lifelong brain infections, thus inflammation, on neurological health host. Toxoplasma gondii a parasite that infect any mammalian nucleated cell with average worldwide seroprevalence rates 30%. Infection by characterized presence parasitic cysts within neurons in brain, requiring competent system prevent reactivation encephalitis. In immunocompetent individual,...
The 5xFAD mouse is a popular model of familial Alzheimer's disease (AD) that characterized by early beta-amyloid (Aβ) deposition and cognitive decrements. Despite numerous studies, the has not been comprehensively phenotyped for vascular metabolic perturbations over its lifespan.Male female wild type (WT) littermates underwent in vivo18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging at 4, 6, 12 months age to assess regional glucose metabolism. A separate cohort mice (4,...
Cerebral edema develops in response to a variety of conditions, including traumatic brain injury and stroke, contributes the poor prognosis associated with these injuries. This study examines use optical coherence tomography (OCT) for detecting cerebral vivo. Three-dimensional imaging an vivo water intoxication model mice was performed using spectral-domain OCT system centered at 1300 nm. The change attenuation coefficient calculated blood flow analyzed Doppler techniques. We found that...
Traumatic brain injury (TBI) is significant, from a public health standpoint, because it major cause of the morbidity and mortality young people. Cerebral edema after TBI, if untreated, can lead to devastating damage remaining tissue. The current therapies severe TBI (sTBI), as outlined by Brain Trauma Foundation, are often ineffective, thus new method for treatment sTBI necessary. Herein, reduction cerebral edema, using an osmotic transport device (OTD) was evaluated. Controlled cortical...
Vascular dysfunction and structural abnormalities in Alzheimer’s disease (AD) are known to contribute the progression of pathology, studies have tended ignore role vasculature AD progression. We utilized 3xTg-AD mouse model examine individual cerebral vessels cortical vascular network across lifespan. Our vessel painting approach was used label entire vasculature, followed by epifluorescence microscopy. The middle artery (MCA) tree assessed with confocal microscopy, a new method developed...
Abstract Objective To determine the role of aquaporin‐4 (AQP4) in posttraumatic epileptogenesis using long‐term video‐electroencephalographic (vEEG) recordings. Here, differences EEG were analyzed between wild‐type (WT) and AQP4 knockout (KO) mice with without epilepsy (PTE). Methods WT KO subjected to a single controlled cortical impact traumatic brain injury (TBI) frontal cortex, vEEG was recorded ipsilateral hippocampus at 14, 30, 60, 90 days postinjury (dpi). Intrahippocampal electrical...
The most common technology for seizure detection is with electroencephalography (EEG), which has low spatial resolution and minimal depth discrimination. Optical techniques using near-infrared (NIR) light have been used to improve upon EEG previous research suggested that optical changes, specifically changes in scattering, may precede onset vivo models. coherence tomography (OCT) a high resolution, minimally invasive imaging technique, can produce resolved cross-sectional images. In this...
Optical coherence tomography (OCT) is a biomedical imaging technique with high spatial-temporal resolution. With its minimally invasive approach OCT has been used extensively in ophthalmology, dermatology, and gastroenterology1-3. Using thinned-skull cortical window (TSCW), we employ spectral-domain (SD-OCT) modality as tool to image the cortex vivo. Commonly, an opened-skull for neuro-imaging it provides more versatility, however, TSCW less effective mean long term neuropathology studies....
Stroke is among the top ten causes of death in children but has received disproportionally little attention. Cerebral arteriopathies account for up to 80% childhood arterial ischemic stroke (CAIS) cases and are strongly predictive CAIS recurrence poorer outcomes. The underlying mechanisms sensitization neurovasculature by viral infection undefined. In first age-appropriate model arteriopathy—by administration mimetic TLR3-agonist Polyinosinic:polycytidylic acid (Poly-IC) juvenile mice—we...
Optical coherence tomography (OCT) is a high resolution, minimally invasive imaging technique, which can produce depth-resolved cross-sectional images.In this study, OCT was used to detect changes in the optical properties of cortical tissue vivo mice during induction global (pentylenetetrazol) and focal (4-aminopyridine) seizures.Through use confidence interval statistical method on volumes attenuation coefficient, we demonstrated localization regions exhibiting both significant positive...
Abstract Background The Model Organism Development and Evaluation for Late‐Onset Alzheimer’s Disease (MODEL‐AD) consortium seeks to develop the next generation of disease models guided by human data. As new mice become available, they are extensively phenotyped compared existing models, such as 5xFAD. 5xFAD familial AD onset, which results in amyloid β (Aβ) deposition cognitive decrements early life; however, no studies have comprehensively vascular metabolic aspects this mouse over its...
Localization of optical changes for focal and global seizure models was used to differentiate active versus inactive cortical tissue in vivo, demonstrating OCT's utility as a tool studying brain activity with high spatiotemporal resolution.
Localization of OCT-derived optical changes in a focal seizure model was used to differentiate active versus inactive cortical tissue vivo, demonstrating OCT's potential as tool for studying brain activity with high spatiotemporal resolution.