A5036788309- Genetics and Neurodevelopmental Disorders
- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- Chromatin Remodeling and Cancer
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Plant Stress Responses and Tolerance
- Glioma Diagnosis and Treatment
- Genetic Syndromes and Imprinting
- Pluripotent Stem Cells Research
- MicroRNA in disease regulation
- Asthma and respiratory diseases
- Signaling Pathways in Disease
- Ubiquitin and proteasome pathways
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Natural product bioactivities and synthesis
- Ion Channels and Receptors
- PARP inhibition in cancer therapy
- Online and Blended Learning
- Protein Degradation and Inhibitors
- Genomics and Rare Diseases
- Melanoma and MAPK Pathways
- Adipokines, Inflammation, and Metabolic Diseases
- Organizational Learning and Leadership
- Ion Transport and Channel Regulation
Université de Strasbourg
2008-2024
Institut Polytechnique de Bordeaux
2024
International Drug Development
2024
Laboratoire d'Innovation Thérapeutique
2010-2018
Centre National de la Recherche Scientifique
1999-2017
University of Central Lancashire Cyprus
2016
Archbishop Makarios III Hospital
2007-2013
Cyprus University of Technology
2010-2011
Inserm
1999-2004
Biotechnologie et Signalisation Cellulaire
2002
Coffin–Lowry syndrome (CLS) is characterized by cognitive impairment, characteristic facial and digital findings skeletal anomalies. The gene implicated in CLS encodes RSK2, a serine/threonine kinase acting the Ras/MAPK signalling pathway. In humans, RSK2 belongs to family of four highly homologous proteins (RSK1–RSK4), encoded distinct genes. mutations patients are extremely heterogeneous. No consistent relationship between specific severity disease or expression uncommon features has been...
To date, all descriptions of legionellosis in neonates have emerged from a small number isolated case reports newborns with unusually severe pneumonia. In December 2008, large outbreak Legionella infection occurred term Cyprus, providing new information on the epidemiological and clinical features Legionellosis this age group.An environmental investigation was performed at private hospital where infected were delivered. The medical records retrospectively reviewed to obtain data...
RSK2 is a growth factor-regulated serine-threonine protein kinase, acting in the Ras-Mitogen-Activated Protein Kinase (MAPK) signaling pathway. Mutations gene (RPS6KA3) on chromosome Xp22.2, have been found to cause Coffin-Lowry syndrome (CLS), an X-linked disorder characterized by psychomotor retardation, characteristic facial and digital abnormalities, progressive skeletal deformations. By screening of 250 patients with clinical features suggestive syndrome, 71 distinct disease-associated...
Research Article4 April 2016Open Access Source DataTransparent process The anti-hypertensive drug prazosin inhibits glioblastoma growth via the PKCδ-dependent inhibition of AKT pathway Suzana Assad Kahn INSERM, UMR-S 1130, Neuroscience Paris Seine-IBPS, Paris, France CNRS, UMR 8246, Sorbonne Universités, UPMC Université 06, Department Neurosurgery, Institute for Stem Cell Biology and Regenerative Medicine Division Pediatric Lucile Packard Children's Hospital, Stanford University, Stanford,...
Whilst emerging evidence from animal and cell experiments has shown high-density lipoprotein cholesterol to have anti-inflammatory effects consistent with a protective role in asthma, human studies investigating the relationship of asthma produced conflicting results.To examine association between serum lipids among Cypriot children aged 11-12 years prevalence at age 15-17 years.In 3982 children, we assessed lipids, body mass index maximal oxygen consumption baseline (2001-2003) explored...
Mouse embryonic stem (ES) cells remain "pluripotent" in vitro the continuous presence of leukemia inhibitory factor (LIF). In absence LIF, ES are irreversibly committed to differentiate into various lineages. this study we have set up an assay based on anti-apoptotic activity LIF distinguish pluripotent from "differentiation-committed" cells. We examined phosphorylation profiles known (STAT3 and ERKs) identified new (ribosomal S6 kinases (RSKs) cAMP-responsive element-binding protein (CREB))...
Glioblastomas (GBMs) are highly aggressive, invasive brain tumors with bad prognosis and unmet medical need. These heterogeneous being constituted by a variety of cells in different states differentiation. Among these, endowed stem properties, tumor initiating/propagating properties particularly resistant to chemo- radiotherapies designed as the real culprits for maintenance relapse after treatment. cells, termed cancer stem-like have been prominent targets new more efficient therapies....
Cancer stem-like cells reside in hypoxic and slightly acidic tumor niches. Such microenvironments favor more aggressive undifferentiated phenotypes a slow growing "quiescent state" which preserves them from chemotherapeutic agents that essentially target proliferating cells. Our objective was to identify compounds active on glioblastoma cells, including under conditions mimick those found vivo within this most severe incurable form of brain malignancy. We screened the Prestwick Library...
Several studies have reported associations between respiratory outcomes in children and a range of self-reported, administrative or geographical indicators traffic pollution. First-time investigation into the frequency asthmatic symptoms among 7-8 year-old Cypriot 1999-2000 showed increased prevalence capital Nicosia compared to other areas. Geographical differences on an island size Cyprus may reflect environmental and/or lifestyle factors. This study investigates relationship self-reported...
Antibody-drug conjugates (ADCs) are a well-established class of therapeutics primarily used in oncology to selectively deliver highly cytotoxic agents into cancer cells. While ADCs should theoretically spare healthy tissues and diminish side effects patients, off-target toxicity is still observed, all the more serious, as drugs extremely potent. In quest toward safer payloads, we conventional chemotherapeutic drug vincristine develop antibody-vincristine conjugates. Vincristine was...
Coffin–Lowry syndrome (CLS) is caused by mutations in the RSK2 gene encoding a protein kinase of Ras signalling pathway. We have studied two point which cause aberrant splicing but do not concern invariant GT or AG nucleotides splice sites. The first, an A→G transition at position +3 5′ site exon 6, results vivo and vitro skipping premature translation termination. natural site, although intrinsically weak, transactivated under normal conditions. Consequently, replacement A/U G/U base...
Glioblastoma is a highly heterogeneous brain tumor. The presence of cancer cells with stem-like and tumor initiation/propagation properties contributes to poor prognosis. (GSC) reside in hypoxic acidic niches favoring cell quiescence drug resistance. A high throughput screening recently identified the laxative Bisacodyl as cytotoxic compound targeting quiescent GSC placed microenvironments. activity requires its hydrolysis into DDPM, pharmacologically active derivative. was further shown...