A5092143432- Protein Structure and Dynamics
- Advanced Neuroimaging Techniques and Applications
- Proteins in Food Systems
- Enzyme Structure and Function
- RNA Research and Splicing
- RNA and protein synthesis mechanisms
Polish Academy of Sciences
2023-2024
Institute of Physics
2023
The diffusion coefficients of globular and fully unfolded proteins can be predicted with high accuracy solely from their mass or chain length. However, this approach fails for intrinsically disordered (IDPs) containing structural domains. We propose a rapid predictive methodology estimating the IDPs. uses accelerated conformational sampling based on self-avoiding random walks includes hydrodynamic interactions between coarse-grained protein subunits, modeled using generalized...
Intrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack a fixed spatial structure facilitates them to perform their regulatory functions and allows the efficiency biochemical reactions be controlled by temperature cellular environment. From biophysical point view, IDPs are biopolymers with broad configuration state space actual conformation depends on non-covalent interactions its amino acid side chain...
Abstract The diffusion coefficients of globular and fully unfolded proteins can be predicted with high accuracy solely from their mass or chain length. However, this approach fails for intrinsically disordered (IDPs) containing structural domains. We propose a rapid predictive methodology estimating the IDPs. uses accelerated conformational sampling based on self-avoiding random walks includes hydrodynamic interactions between coarse-grained protein subunits, modeled using generalized...
Abstract Intrinsically disordered proteins (IDPs) form an important class of biomolecules regulating biological processes in higher organisms. The lack a fixed spatial structure facilitates them to perform their regulatory functions. Due the possibility large conformational changes IDPs, cellular milieu can also control productivity biochemical reactions. From biophysical point view, IDPs are biopolymers with broad configuration state space. conformation such biopolymer depends on...