A5090698113- Ocular Oncology and Treatments
- Glioma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Corneal Surgery and Treatments
- Glutathione Transferases and Polymorphisms
- DNA Repair Mechanisms
- Cancer Immunotherapy and Biomarkers
- Ocular Infections and Treatments
- Carcinogens and Genotoxicity Assessment
- Ubiquitin and proteasome pathways
Linyi People's Hospital
2018-2020
Xintai People's Hospital
2015
BACKGROUND BCL2 19 kD protein-interacting protein 3 (BNIP3) is a BH3-containing of the BCL-2 family; it can regulate cell death, autophagy, and cytoprotection. The upregulation BNIP3 has been reported to relate progression poor prognosis in different cancer types. However, clinical significance uveal melanoma (UM) still unknown. MATERIAL AND METHODS In our study, 47 patients with UM were enrolled; expression was detected immunohistochemistry. According immunohistochemical scores, divided...
The effect of single nucleotide polymorphisms (SNPs) at MDM2 has been investigated in several cancer types. Three SNPs(rs937283, rs2270744 and rs769412) have previously suggested to be positively correlated with cancer. In this study, we aimed explore the association rs937283, rs769412 retinoblastoma (RB) risk, clinicopathological characteristics, prognosis. Compared wild-type genotype AA individuals carrying AG GG had a significantly increased risk for developing RB (OR = 1.86, 95% CI...
BACKGROUND Uveal melanoma (UM) is the most common intraocular malignancy, and prognosis of patients with advanced stage UM very dismal. The T cell receptor ectopic expression butyrophilin-like 9 (BTNL9) has been observed in several types cancers, but clinical significance BTNL9 unclear. MATERIAL AND METHODS In our study, we detected 6 pairs tissues adjacent using quantitative real-time polymerase chain reaction (qRT-PCR), further investigated immunohistochemistry (IHC) a retrospective cohort...
Uveal melanoma is one of the most common primary intraocular malignant tumors with poor prognosis and limited treatments. Programmed cell death receptor-1 (PD-1) blockade represents treatment strategy immune checkpoint inhibition; however, there a lack studies on whether PD-1 expression in (ocular) uveal affects tumor progression.PD-1 82 cases was detected by immunohistochemistry. The clinical significance evaluated using univariate multivariate analysis. overexpression knockdown were...
The aim of this study was to examine the relationship between genetic polymorphisms in DNA ligase 1 (LIG1) and non-small cell lung cancer (NSCLC) susceptibility radiosensitivity a Chinese population. This case-control that included 352 NSCLC patients 448 healthy controls. Polymerase chain reaction-restriction fragment length polymorphism analysis conducted detect HaeIII exon 6 LIG1 gene popula-tion. information used observe effects radiation pa-tients with different genotypes order determine...