A5014438127- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Cell Image Analysis Techniques
- Photoreceptor and optogenetics research
- Educational and Social Studies
- Memory and Neural Mechanisms
- Educational Tools and Methods
- Advanced Fluorescence Microscopy Techniques
- stochastic dynamics and bifurcation
- Advanced Memory and Neural Computing
- Single-cell and spatial transcriptomics
- Genomics and Phylogenetic Studies
- Force Microscopy Techniques and Applications
- Species Distribution and Climate Change
- Neurobiology and Insect Physiology Research
- Zebrafish Biomedical Research Applications
- 3D Modeling in Geospatial Applications
- Augmented Reality Applications
- Geological Modeling and Analysis
- RNA and protein synthesis mechanisms
- Scientific Computing and Data Management
- Language and cultural evolution
New York Consortium in Evolutionary Primatology
2025
Evolutionary Genomics (United States)
2024
Chan Zuckerberg Initiative (United States)
2021
Janelia Research Campus
2014-2017
Howard Hughes Medical Institute
2014-2016
Imaging is used to map activity across populations of neurons. Microscopes with cellular resolution have small (<1 millimeter) fields view and cannot simultaneously image distributed multiple brain areas. Typical large field microscopes do not resolve single cells, especially in the axial dimension. We developed a 2-photon random access mesoscope (2p-RAM) that allows high-resolution imaging anywhere within volume spanning areas (∅ 5 mm x 1 cylinder). 2p-RAM near diffraction limited...
More than three billion years of evolution have produced an image biology encoded into the space natural proteins. Here we show that language models trained at scale on evolutionary data can generate functional proteins are far away from known We present ESM3, a frontier multimodal generative model reasons over sequence, structure, and function ESM3 follow complex prompts combining its modalities is highly responsive to alignment improve fidelity. prompted fluorescent Among generations...
Cells are essential to understanding health and disease, yet traditional models fall short of modeling simulating their function behavior. Advances in AI omics offer groundbreaking opportunities create an virtual cell (AIVC), a multi-scale, multi-modal large-neural-network-based model that can represent simulate the behavior molecules, cells, tissues across diverse states. This Perspective provides vision on design how collaborative efforts build AIVCs will transform biological research by...
During many natural behaviors the relevant sensory stimuli and motor outputs are difficult to quantify. Furthermore, high dimensionality of space possible movements compounds problem experimental control. Head fixation facilitates stimulus control movement tracking, can be combined with techniques for recording manipulating neural activity. However, head-fixed mouse typically trained through extensive instrumental conditioning. Here we present a whisker-based, tactile virtual reality system...
Animals seek out relevant information by moving through a dynamic world, but sensory systems are usually studied under highly constrained and passive conditions that may not probe important dimensions of the neural code. Here, we explored coding in barrel cortex head-fixed mice tracked walls with their whiskers tactile virtual reality. Optogenetic manipulations revealed plays role wall-tracking. Closed-loop optogenetic control layer 4 neurons can substitute for whisker-object contact to...
Abstract Imaging is used to map activity across populations of neurons. Microscopes with cellular resolution have small (< 1 millimeter) fields view and cannot simultaneously image distributed multiple brain areas. Typical large field microscopes do not resolve single cells, especially in the axial dimension. We developed a 2-photon random access mesoscope (2p-RAM) that allows high-resolution imaging anywhere within volume spanning areas (Ø 5 mm × cylinder). 2p-RAM near diffraction...
Neurons relevant to a particular behavior are often widely dispersed across the brain. To record activity in groups of individual neurons that might be distributed large distances, neuroscientists and optical engineers have been developing new type microscope called mesoscope. Mesoscopes high spatial resolution field view. This Q&A will discuss this exciting technology, highlighting instrument, two-photon random access mesoscope (2pRAM).
Announcement: napari 0.2.9 We're happy to announce the release of 0.2.9! is a fast, interactive, multi-dimensional image viewer for Python. It's designed browsing, annotating, and analyzing large images. built on top Qt (for GUI), vispy performant GPU-based rendering), scientific Python stack (numpy, scipy). For more information, examples, documentation, please visit our website: https://github.com/napari/napari Highlights better support surface timeseries (#831) contrast limits slider popup...
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