A5061894573- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Viral Infections and Outbreaks Research
- Biosensors and Analytical Detection
- Bacteriophages and microbial interactions
- Genomics and Phylogenetic Studies
- Microbial infections and disease research
- Viral gastroenteritis research and epidemiology
- Data-Driven Disease Surveillance
- Plant Virus Research Studies
- Influenza Virus Research Studies
- Advanced Biosensing Techniques and Applications
- COVID-19 epidemiological studies
- COVID-19 Pandemic Impacts
Los Alamos National Laboratory
2020-2022
Genomics has become an essential technology for surveilling emerging infectious disease outbreaks. A range of technologies and strategies pathogen genome enrichment sequencing are being used by laboratories worldwide, together with different, sometimes ad hoc, analytical procedures generating sequences. fully integrated process raw sequence to consensus determination, suited outbreaks such as the ongoing COVID-19 pandemic, is critical provide a solid genomic basis epidemiological analyses...
Polymerase chain reaction-based assays are the current gold standard for detecting and diagnosing SARS-CoV-2. However, as SARS-CoV-2 mutates, we need to constantly assess whether existing PCR-based will continue detect all known viral strains. To enable continuous monitoring of assays, have developed a web-based assay validation algorithm that checks against ever-expanding genome databases using both thermodynamic edit-distance metrics. The assay-screening results displayed heatmap, showing...
Detection methods that do not require nucleic acid amplification are advantageous for viral diagnostics due to their rapid results. These platforms could provide information both accurate diagnoses and pandemic surveillance. Influenza virus is prone pandemic-inducing genetic mutations, so there a need apply these detection influenza diagnostics. Here, we analyzed the Fast Evaluation of Viral Emerging Risks (FEVER) pipeline on ultrasensitive platforms, including waveguide-based optical...
Viral pathogens can rapidly evolve, adapt to novel hosts, and evade human immunity. The early detection of emerging viral through biosurveillance coupled with rapid accurate diagnostics are required mitigate global pandemics. However, RNA viruses mutate rapidly, hampering diagnostic efforts. Here, we present a computational approach called FEVER (Fast Evaluation Emerging Risks) design assays that simultaneously accomplish: 1) broad-coverage an entire group viruses, 2) diagnosis outbreak...
Public health practitioners rely on timely surveillance data for planning and decision-making; however, are often subject to delays. Epidemic trend categories, based time-varying effective reproductive number (R
ABSTRACT Viral pathogen can rapidly evolve, adapt to novel hosts and evade human immunity. The early detection of emerging viral pathogens through biosurveillance coupled with rapid accurate diagnostics are required mitigate global pandemics. However, RNA viruses mutate rapidly, hampering diagnostic efforts. Here, we present a computational approach called FEVER (Fast Evaluation Emerging Risks) design assays that simultaneously accomplish: 1) broad-coverage an entire class viruses, 2)...
Genomics has become an essential technology for surveilling emerging infectious disease outbreaks. A wide range of technologies and strategies pathogen genome enrichment sequencing are being used by laboratories worldwide, together with different, sometimes ad hoc, analytical procedures generating sequences. As a result, public repositories now contain non-standard entries varying quality. standardized process consensus sequence determination, particularly outbreaks such as the ongoing...
Summary: Polymerase chain reaction-based assays are the current gold standard for detecting and diagnosing SARS-CoV-2. However, as SARS-CoV-2 mutates, we need to constantly assess whether existing PCR-based will continue detect all known viral strains. To enable continuous monitoring of assays, have developed a web-based assay validation algorithm that checks against ever-expanding genome databases using both thermodynamic edit-distance metrics. The screening results displayed heatmap,...