A5034864975- Hematopoietic Stem Cell Transplantation
- Telomeres, Telomerase, and Senescence
- Acute Myeloid Leukemia Research
- Neonatal Respiratory Health Research
- Cytomegalovirus and herpesvirus research
- CRISPR and Genetic Engineering
- Childhood Cancer Survivors' Quality of Life
- Polyomavirus and related diseases
- Mesenchymal stem cell research
- Acute Lymphoblastic Leukemia research
- Blood disorders and treatments
Hospital de Clínicas Universidade Federal do Paraná
2021-2024
Universidade Federal do Paraná
2014-2023
<title>Abstract</title> <bold>Objective</bold> To measure the 1st to 5th digits, palmar, hallucal, and heel regions of full-term newborns define anatomical reference values for neonatal biometric device design. <bold>Study Design</bold> A cross-sectional study conducted at a public university hospital in southern Brazil. Anthropometric measurements were obtained bilaterally from 34 (39–41 weeks gestation) using precision digital caliper. <bold>Result</bold> The mean length 2nd digits was...
Telomere biology diseases (TBD) result from defective telomere maintenance, leading to bone marrow failure. The only curative treatment for aplastic anemia related TBD is a hematopoietic cell transplant (HCT). Although reduced-intensity conditioning (RIC) regimens decrease transplant-related mortality, non-hematological phenotypes represent major challenge and are associated with poor long-term follow-up outcomes.To describe the outcome of patients transplanted failure.This retrospective,...
Summary Aplastic anaemia in infants and young children presents unique challenges due to high prevalence of inherited bone marrow failure syndromes (IBMFS) this age group. The objective study is assessing clinical characteristics outcomes haematopoietic cell transplantation ≤5 years with syndromes. We analysied 106 patients (66% males), median 4.6 years, including 40 Fanconi (FA), 32 Acquired Severe (aSAA), 15 Diamond–Blackfan Anaemia, 11 Amegakaryocytic Purpura 8 other IBMFS. Molecular...
Abstract With the number of long‐term HSCT survivors steadily increasing, attention needs to be focused on late complications and quality life. We therefore analyzed outcome 101 pediatric patients (<18 years old at time HSCT) transplanted for acute leukemia between 1981 2015 Complexo Hospital de Clínicas, Federal University Paraná, Brazil, who survived least two after HSCT. The median follow‐up was 5.9 (2.0‐29.0); age 17.5 (2.98‐39.0). 5‐year cumulative incidence relapse 27.5% (95% CI...
Umbilical cord blood (UCB) is an alternative option for hematopoietic stem cell transplantation and it has been successfully used to treat children with malignant non diseases. The slower rate of neutrophil engraftment delayed immune reconstitution impose a substantial risk infections mortality. Furthermore, the use anti-thymocyte globulin (ATG) linked higher viral infections. In order assess occurrence we retrospectively analyzed outcomes 156 who underwent UCB transplant (UCBT) between...
Aims & Objectives: Retrospective cross-sectional analysis of 321 children following HSTC under 15 years age, from January 2010 to December 2018 Methods: Factors related HSCT, indication intensive care, presence organ dysfunction, days after mechanical ventilation (MV) and inotropic time, evolution, were analyzed. Results: Of 321, 51 (15.8%) required care between 0 728 the first HSCT (M = 22). Median age was 7 66.6% boys. Indication for in 80.4% non-malignant disease 58.8% used unrelated...