A5001109904- Blood groups and transfusion
- Cancer Treatment and Pharmacology
- Multiple Myeloma Research and Treatments
- Complement system in diseases
- Parvovirus B19 Infection Studies
- Immune Cell Function and Interaction
- Renal Diseases and Glomerulopathies
- Cholinesterase and Neurodegenerative Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Blood disorders and treatments
- Inflammasome and immune disorders
- Urticaria and Related Conditions
- Bacterial Infections and Vaccines
- Pituitary Gland Disorders and Treatments
- Platelet Disorders and Treatments
Nordland Hospital
2012-2023
Eculizumab is a humanized IgG2/4 chimeric anti-complement C5 antibody used to treat patients with paroxysmal nocturnal hemoglobinuria (PNH) or atypical hemolytic uremic syndrome. The aim of this study was evaluate whether not the complement activity in newborns from pregnant women who receive eculizumab impaired. A novel eculizumab-C5 complex (E-C5) specific assay developed and revealed that two carried only 6-7% E-C5 detected their eculizumab-treated PNH mothers. Serum completely lacked...
BACKGROUND Schnitzler's syndrome is a rarely acquired and probably underdiagnosed disorder. It type of autoinflammatory condition with late onset. CASE PRESENTATION A man in his fifties had recurrent urticaria, fever chronic joint pain during the previous year. After an extensive investigation, no evidence infection, autoimmune disease or malignancy were found. Blood samples showed moderately elevated SR CRP, mild thrombocytosis presence monoclonal IgM low concentration (MGUS). The...