A5029756048- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Coordination Chemistry and Organometallics
- Fluorine in Organic Chemistry
- Asymmetric Synthesis and Catalysis
- Crystallography and molecular interactions
- Synthesis and Properties of Aromatic Compounds
- Synthesis of Tetrazole Derivatives
- Molecular Spectroscopy and Structure
- Chemical Reaction Mechanisms
- Radical Photochemical Reactions
- Inorganic Fluorides and Related Compounds
- Computational Drug Discovery Methods
- Catalytic C–H Functionalization Methods
- Chemical Synthesis and Analysis
PRG S&Tech (South Korea)
2025
Chungnam National University
2025
Johns Hopkins University
2022-2024
The putative interaction of a C-F bond with an amide carbonyl has been intriguing topic interest in this century for reasons spanning basic physical organic chemistry to biochemistry. However, date, there exist no examples close, well-defined which its unique aspects can be identified and exploited. Herein, we finally present engineered system possessing exceptionally tight C-F-amide interaction, allowing us obtain spectroscopic, crystallographic, kinetic details distinctive, biochemically...
In 2015, we reported a photochemical method for directed C-C bond cleavage/radical fluorination of relatively unstrained cyclic acetals using Selectfluor and catalytic 9-fluorenone. Herein, provide detailed mechanistic study this reaction, during which it was discovered that the key electron transfer step proceeds through substrate oxidation from Selectfluor-derived N-centered radical intermediate (rather than initially suspected photoinduced transfer). This finding led to proof concept two...
The CF3 group is well noted for being noninteractive with other functional groups. In this Note, we present a highly rigid model system containing significant hydrogen bonding interaction between charged N–H donor and acceptor that challenges accepted wisdom. Spectroscopic single crystal X-ray crystallography data characterize interaction, consistent weak to moderate bond would be difficult observe in an intermolecular system.
Abstract We report a detailed experimental and theoretical analysis of through‐space arene activation with halogens, tetrazoles achiral esters amides. Contrary to previously assumed direct through σ‐complex stabilization, our results suggest that these reactions proceed by relay mechanism wherein the lone pair‐containing activators form exothermic π‐complexes electrophilic nitronium ion before transferring it probe ring low barrier transition states. Noncovalent interactions (NCI) plots...
We have found that face-to-face π-stacked aromatic rings show the propensity to activate one another toward electrophilic substitution through direct influence of probe ring by adjacent stacked ring, rather than formation relay or "sandwich complexes." This activation remains in force even when is deactivated nitration. The resulting dinitrated products are shown crystallize an extended parallel offset form, stark contrast substrate.
Abstract The putative interaction of a C−F bond with an amide carbonyl has been intriguing topic interest in this century for reasons spanning basic physical organic chemistry to biochemistry. However, date, there exist no examples close, well‐defined which its unique aspects can be identified and exploited. Herein, we finally present engineered system possessing exceptionally tight C−F‐amide interaction, allowing us obtain spectroscopic, crystallographic, kinetic details distinctive,...