A5027660697- Reproductive Physiology in Livestock
- Veterinary Equine Medical Research
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- RNA Research and Splicing
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Reproductive biology and impacts on aquatic species
- Veterinary Medicine and Surgery
- Ruminant Nutrition and Digestive Physiology
- Diabetes Management and Research
- Diabetes and associated disorders
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Ovarian function and disorders
- Animal health and immunology
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pancreatic function and diabetes
- Muscle metabolism and nutrition
- Fungal and yeast genetics research
- Exercise and Physiological Responses
- Plant and Fungal Interactions Research
- Animal Genetics and Reproduction
- Gastrointestinal motility and disorders
- Animal Behavior and Welfare Studies
University of Veterinary Medicine Vienna
2022-2024
Universidade La Salle
2024
MODUL University Vienna
2018-2023
The Enteric Nervous System in Gut and Brain Disorders
2023
Centre Hospitalier Universitaire de Nantes
2023
Adocia (France)
2023
Inserm
2022
Nantes Université
2022
Institut Curie
2017-2021
Université Paris Sciences et Lettres
2017-2021
Antisense transcription can regulate sense gene expression. However, previous annotations of antisense units have been based on detection mature long noncoding (aslnc)RNAs by RNA-seq and/or microarrays, only giving a partial view the landscape and incomplete molecular bases for antisense-mediated regulation. Here, we used native elongating transcript sequencing to map genome-wide nascent in fission yeast. Strikingly, was detected most protein-coding genes, correlating with low transcription,...
Pregnant mares and post-weaning foals are often fed concentrates rich in soluble carbohydrates, together with forage. Recent studies suggest that the use of is linked to alterations metabolism development osteochondrosis foals. The aim this study was determine if broodmare diet during gestation affects metabolism, osteoarticular status growth yearlings overfed from 20 24 months age and/or sexual maturity prepubertal colts.Twenty-four saddlebred were forage only (n = 12, group F) or cracked...
Introduction Obesity is a growing concern in horses. The effects of maternal obesity on metabolism and low-grade inflammation during pregnancy, as well offspring growth, metabolism, inflammation, testicular maturation osteochondrotic lesions until 18 months age were investigated. Material methods Twenty-four mares used separated into two groups at insemination according to body condition score (BCS): Normal (N, n = 10, BCS ≤4) Obese (O, 14, ≥4.25). plasma glucose, insulin, triglyceride,...
It is important to accurately regulate the expression of genes involved in development and environmental response. In fission yeast Schizosaccharomyces pombe, meiotic are tightly repressed during vegetative growth. Despite being embedded heterochromatin these transcribed believed be primarily at level RNA. However, mechanism facultative formation interplay with transcription regulation not understood. We show genome-wide that HDAC-dependent histone deacetylation a major determinant...
In female animals of different species, Anti-Müllerian hormone (AMH) is produced by follicular granulosa cells and has been associated with the ovarian follicle pool. Because concentration AMH in plasma ovary-intact cats apparently more variable than previously assumed, we have analysed blood (n = 93) presented for routine ovariectomy assessed histology protein expression surgically removed ovaries. We hypothesised that synthesized only preantral small antral follicles reflects count (AFC)....
This study aimed to characterize the response of transport-naïve dogs one and two-hour road transports based on cortisol in saliva blood plasma, heart rate, rate variability (HRV), neutrophil lymphocyte (N/L) ratio behavior. Two persons familiar were present during control experiments. We hypothesized that transport elicits a stress response, which decreases with repeated transports. Beagle allocated three groups (n = 6 each). Group 1 served as stable week was transported for hour weeks 2, 3...
GATA transcription factors are highly conserved among eukaryotes and play roles in of genes implicated cancer progression hematopoiesis. However, although their consensus binding sites have been well defined vitro, the vivo selectivity for recognition by remains poorly characterized. Using ChIP-Seq, we identified Dal80 factor targets yeast. Our data reveal to a large set promoters, sometimes independently sites, correlating with nitrogen- and/or Dal80-sensitive gene expression. Strikingly,...
Oestrogens and 1α,25(OH)2-vitamin D3 (1,25-D3) are steroids that can provide effects by binding to their receptors localised in the cytoplasm nucleus or plasma membrane respectively inducing genomic non-genomic effects. As confirmed notably invalidation of genes, coding for as tested with mice vivo vitro treatments, oestrogens 1,25-D3 regulators spermatogenesis. Moreover, some functions ejaculated spermatozoa viability, DNA integrity, motility, capacitation, acrosome reaction fertilizing...
Repeated acute stress (RASt) is known to be associated with gastrointestinal dysfunctions. However, the mechanisms underlying these effects have not yet been fully understood. While glucocorticoids are clearly identified as hormones, their involvement in RASt-induced gut dysfunctions remains unclear, does function of glucocorticoid receptors (GR). The aim our study was evaluate GR on changes motility, particularly through enteric nervous system (ENS).Using a murine water avoidance (WAS)...
Antisense (as)lncRNAs can regulate gene expression but the underlying mechanisms and different cofactors involved remain unclear. Using Native Elongating Transcript sequencing, here we show that stabilization of antisense Exo2-sensitivite lncRNAs (XUTs) results in attenuation, at nascent transcription level, a subset highly expressed genes displaying prominent promoter-proximal nucleosome depletion histone acetylation. Mechanistic investigations on catalase ctt1 revealed its induction...
Blue light directed at 1 eye advances the equine ovulatory season but may also advance foaling. In this study, effects of blue LED on pregnancy outcome were assessed. A total 20 mares with singleton pregnancies studied over 2 consecutive years in a cross-over design. year, received an extended photoperiod using 50 lux (468 nm) single from 08:00 until 23:00 daily via head-worn masks starting mid-December and other year remained untreated as controls. Gestation was shorter light-treated than...
We followed the hypothesis that equine neonates with reduced transfer of tumor necrosis factor-α (TNFα) are at increased risk neonatal infection. investigated TNFα concentrations in colostrum healthy mares and blood their a non-hospitalized population Warmblood where delivery, adaptation health was closely monitored by veterinarians. Concentration IgG determined respective milk collected immediately after delivery 18 h thereafter 97 foals were assigned to groups failure passive (FPT; n = 31)...
Mares resume ovarian activity rapidly after foaling. Besides follicle-stimulating hormone (FSH) and luteinizing (LH), the pituitary synthesizes prolactin growth which stimulate insulin-like factor (IGF) synthesis in liver. We tested hypothesis that follicular is initiated already antepartum, mares with early delayed ovulation differ IGF-1 release there an additional placenta. Plasma concentrations of LH, FSH, IGF-1, IGF-2, activin prolactin. their receptors placental tissues were analyzed at...
The aim of the present study was to characterise key enzymes involved in polyunsaturated fatty acid (PUFA) synthesis testis and epididymis collected from 2-year-old healthy warmblood stallions (n=10). mRNA expression synthase, Δ9-, Δ6-, Δ5- Δ4-desaturases elongases 6, 5 2 (encoded by synthase (FASN), stearoyl-CoA desaturase (SCD), (FADS2), 1 (FADS1), delta 4-desaturase, sphingolipid (DEGS1), ELOVL elongase 6(ELOVL6), (ELOVL5), (ELOVL2) genes respectively) determined equine epididymis. All...
The use of microfluidic technology is increasing in artificial reproduction technologies: With a small amount semen, it allows for the selection sperm with best characteristics kinetics, morphology and chromatin integrity. ZyMot Multi (850 μl) most popular device Fertility Inc. To date, was proven to be valid instrument vitro fertilization intracytoplasmic injection men. aim this study test efficacy stallion semen. Frozen-thawed semen from 15 stallions that were previously classified as...