A5050357732- Advanced Drug Delivery Systems
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Advancements in Transdermal Drug Delivery
- Diabetes Management and Research
Zhejiang University
2022-2023
Insulin and glucagon secreted from the pancreas with dynamic balance play a vital role in regulating blood glucose levels. Although distinct glucose-responsive insulin delivery systems have been developed, lack of self-regulated release module limits their clinical applications due to potential risk hypoglycemia. Here, we describe transdermal polymeric microneedle patch for closed-loop achieve glycemic regulation minimized The phenylboronic acid units can bind reversibly shift net charge...
Regulatory T (Treg) cells underlie multiple autoimmune disorders and potentialize an anti-inflammation treatment with adoptive cell therapy. However, systemic delivery of cellular therapeutics often lacks tissue targeting accumulation for localized diseases. Besides, the instability plasticity Treg also induce phenotype transition functional loss, impeding clinical translation. Here, we developed a perforated microneedle (PMN) favorable mechanical performance spacious encapsulation cavity to...