A5006592585- Renal Transplantation Outcomes and Treatments
- Cytomegalovirus and herpesvirus research
- Transplantation: Methods and Outcomes
- Organ Transplantation Techniques and Outcomes
- Immunotherapy and Immune Responses
- Organ Donation and Transplantation
- T-cell and B-cell Immunology
- Pregnancy and Medication Impact
- Renal Diseases and Glomerulopathies
- Blood donation and transfusion practices
- Organ and Tissue Transplantation Research
- Renal and Vascular Pathologies
- Medicinal Plant Pharmacodynamics Research
- Immune Cell Function and Interaction
- RNA Interference and Gene Delivery
- Genomic variations and chromosomal abnormalities
- SARS-CoV-2 and COVID-19 Research
- Genetic Associations and Epidemiology
- HIV/AIDS Research and Interventions
- Xenotransplantation and immune response
- vaccines and immunoinformatics approaches
- Viral Infections and Immunology Research
- Hepatitis B Virus Studies
- Genomics and Rare Diseases
University of Toledo Medical Center
2016-2025
University of Toledo
2015-2024
Gift of Life Michigan
2019
Background/Objectives: Kidney transplantation (KT) is the preferred treatment for end-stage renal disease (ESRD), offering improved quality of life, superior survival rates and lower economic burden. However, improving long-term kidney allograft post remains a significant challenge. HLA eplet matching has emerged as promising strategy to minimize immunological risk enhance graft survival. Still, our understanding immunogenicity limited. This study aims evaluate if Electrostatic mismatch...
HLA matching improves long-term outcomes of kidney transplantation, yet implementation challenges persist, particularly within the African American (Black) patient demographic due to donor scarcity. Consequently, survival rates among Black patients significantly lag behind those other racial groups. A refined scheme holds promise for improving survival, with prioritized potentially bolstering HLA-matched transplants. To facilitate quantity, quality and equity in transplants, we propose two...
Introduction Kidney transplants fail more often in Black than non-Black (White, Hispanic, and Asian) recipients. We used the estimated physicochemical immunogenicity for polymorphic amino acids of donor/recipient HLAs to select weakly immunogenic kidney vs. White or patients. Methods OPTN data 65,040 pairs over a 20-year period were calculate individual by hydrophobic, electrostatic acid mismatch scores (HMS, EMS, AMS) graft-survival outcomes recipients, using Kaplan-Meier survival Cox...
Nucleotide sequence differences on the whole-genome scale have been computed for 1,092 people from 14 populations publicly available by 1000 Genomes Project. Total number of in genetic variants between 96,464 human pairs has calculated. The distributions these individuals within European, Asian, or African origin were characterized narrow unimodal peaks with mean values 3.8, 3.5, and 5.1 million, respectively, standard deviations 0.1–0.03 million. total numbers genomic all known relatives...
Immunosuppressed kidney transplant (KT) recipients produce a weaker response to COVID-19 vaccination than immunocompetent individuals. We tested antiviral IgG in 99 KT and 66 healthy volunteers who were vaccinated with mRNA-1273 Moderna or BNT162b2 Pfizer-BioNTech vaccines. A subgroup of participants had their peripheral blood leukocytes (PBLs) evaluated for the frequency T helper 1 (Th1) cells producing IL-2, IFN-γ and/or TNF-α, IL-10-producing T-regulatory (Tr) cells. Among recipients,...
We evaluated the impact of human leukocyte antigen (HLA) disparity (immunogenicity; IM) on long-term kidney allograft survival. The IM was quantified based physicochemical properties polymorphic linear donor/recipient HLA amino acids (the Cambridge algorithm) as a hydrophobic mismatch score (HMS). High-resolution HLA-A/B/DR/DQ types were imputed to calculate HMS for primary/re-transplant recipients deceased donor transplants. multiple Cox regression showed association with graft survival and...
High-resolution typing of human leukocyte antigen (HLA) may revolutionize the field kidney transplantation by selection low immunogenic grafts. The new 250-nautical mile circle allocation system offers a unique opportunity to find HLA donors for eligible recipients.
Immunosuppressed kidney transplant (KT) recipients respond weaker to COVID-19 vaccination than immunocompetent individuals. We tested antiviral IgG response in 99 KT-recipients and 66 healthy volunteers who were vaccinated with mRNA-1273 Moderna or BNT162b2 Pfizer-BioNTech vaccines. A subgroup of participants had their peripheral blood leukocytes (PBLs) evaluated for the frequency T helper 1 (Th1) cells producing IL-2, IFN-γ and/or TNF-α, IL-10-producing T-regulatory (Tr) cells. Among...
Kidney transplantation can significantly enhance living standards for people suffering from end-stage renal disease. A significant factor that affects graft survival time (the until the transplant fails and patient requires another transplant) kidney is compatibility of Human Leukocyte Antigens (HLAs) between donor recipient. In this paper, we propose 4 new biologically-relevant feature representations incorporating HLA information into machine learning-based analysis algorithms. We evaluate...