A5041317583- Developmental Biology and Gene Regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Hippo pathway signaling and YAP/TAZ
- Genomics and Chromatin Dynamics
- Genomic variations and chromosomal abnormalities
- Pancreatic and Hepatic Oncology Research
- Ubiquitin and proteasome pathways
- Liver Disease and Transplantation
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cellular Mechanics and Interactions
- Organ Transplantation Techniques and Outcomes
- Neurobiology and Insect Physiology Research
- Viral-associated cancers and disorders
- Hepatitis C virus research
- Genomics and Phylogenetic Studies
- Liver Disease Diagnosis and Treatment
- Chromosomal and Genetic Variations
- Cellular transport and secretion
- RNA Research and Splicing
- Liver physiology and pathology
- Signaling Pathways in Disease
University of Chicago
2018-2025
Institute for Stem Cell Biology and Regenerative Medicine
2023
Stanford University
2017
City of Hope
2009-2010
Racial, ethnic, and socioeconomic disparities in the survival of patients with hepatocellular carcinoma (HCC) continue to exist. The authors this report hypothesized that these differences result from inequities access care response therapy.Patients HCC (n = 20,920) were identified Surveillance, Epidemiology, End Results (SEER) database, who underwent liver transplantation for 4735) United Network Organ Sharing (UNOS) database. Clinical pathologic factors compared after stratified by race...
An elevated serum α-fetoprotein (AFP) level before orthotopic liver transplant (OLT) is predictive of mortality after OLT for hepatocellular carcinoma (HCC).Retrospective analysis a population-based cohort.United Network Organ Sharing registry (2003-2008).We identified 2253 patients who underwent HCC with available pre-OLT AFP values.Patients were stratified by levels into low (<20 ng/mL), medium (20-399 or high (≥400 ng/mL) groups. Clinical and pathological characteristics compared among...
Precise output from the conserved Notch signaling pathway governs a plethora of cellular processes and developmental transitions. Unlike other pathways that use cytoplasmic relay, cell surface receptor transduces directly to nucleus, with endocytic trafficking providing critical regulatory nodes. Here we report tyrosine kinase Abelson (Abl) facilitates internalization into late endosomes/multivesicular bodies (LEs), thereby limiting in both ligand-dependent -independent contexts. Abl...
The acquisition of cellular identity during development depends on precise spatiotemporal regulation gene expression, with combinatorial interactions between transcription factors, accessory proteins and the basal machinery together translating complex signaling inputs into appropriate expression outputs. Drosophila ETS family factors Yan Pointed, whose opposing repressive activating orchestrate numerous cell fate transitions downstream receptor tyrosine kinase signaling, provide one premier...
ABSTRACT How complex organs coordinate cellular morphogenetic events to achieve three-dimensional (3D) form is a central question in development. The uniquely tractable the late Drosophila pupal retina, where cells maintain stereotyped contacts as they elaborate specialized cytoskeletal structures that pattern apical, basal and longitudinal planes of epithelium. In this study, we combined cell type-specific genetic manipulation regulator Abelson (Abl) with 3D imaging explore how distinct...
An increasing demand for transplant donor organs has made optimal allocation of resources a priority. Our objective was to evaluate outcomes orthotopic liver transplantation (OLT) performed in the United States. A query Network Organ Sharing registry between 1988 and 2007 patients who underwent OLT all etiologies. Patients were stratified by pathology necessitating clinical pathologic factors compared. Multivariate Cox-regression analysis used assess association with survival. Of 61,823...
We present a method to detect copy number variants (CNVs) that are differentially between two groups of sequenced samples. use finite-state transducer where the emitted read depth is conditioned on mappability and GC-content all reads occur at given base position. In this model, within region mixture binomials, which in simulations matches more closely than often-used negative binomial distribution. The analyzes samples simultaneously, preserving uncertainty as breakpoints magnitude CNVs an...
Cell state transitions are often triggered by large changes in the concentrations of transcription factors and therefore differences their stoichiometric ratios. Whether cells can elicit using modest ratios co-expressed is unclear. Here, we investigate how Drosophila eye resolve quantifying expression dynamics ETS Pnt Yan. Eye progenitor maintain a relatively constant ratio Pnt/Yan protein, despite expressing both proteins with pulsatile dynamics. A rapid sustained twofold increase...
Portal vein embolization (PVE) has been used to induce hypertrophy in future liver remnants (FLRs) preparation for major hepatic resection. We report our initial experience with PVE and identify potential predictors of unresectability following PVE.Patients primary metastatic malignancies (n = 20) who underwent between 2004 2008 were categorized by surgical resection status clinicopathologic factors compared.The cohort had the histologies: colorectal adenocarcinoma (45%, n 9), hepatocellular...
Abstract Precise output from the conserved Notch signaling pathway governs a plethora of cellular processes and developmental transitions. Unlike other pathways that use cytoplasmic relay, cell surface receptor transduces directly to nucleus, with endocytic trafficking providing critical regulatory nodes. Here we report tyrosine kinase Abelson (Abl) facilitates internalization into late endosomes/multivesicular bodies (LEs), thereby limiting in both ligand-dependent -independent contexts....
ABSTRACT Cell state transitions are often triggered by large changes in the absolute concentrations of transcription factors and therefore differences stoichiometric ratios between these factors. Whether cells can elicit using modest relative co-expressed is unclear. In this study we investigate how Drosophila eye resolve cell quantifying expression dynamics ETS Pnt Yan. We find that progenitor maintain a relatively constant ratio Pnt/Yan protein despite expressing both proteins with...
Abstract How complex three-dimensional (3D) organs coordinate cellular morphogenetic events to achieve the correct final form is a central question in development. The uniquely tractable late Drosophila pupal retina where cells maintain stereotyped contacts as they elaborate specialized cytoskeletal structures that pattern apical, basal and longitudinal planes of epithelium. In this study, we combined cell type-specific genetic manipulation regulator Abelson (Abl) with 3D imaging explore how...
Abstract The conserved Notch signaling pathway coordinates diverse cellular processes during animal development. Unlike most cell surface receptors that use a cytoplasmic cascade to amplify and diversify dynamics, itself transduces external cues directly the nucleus. How appropriate dynamics transcriptional responses are achieved with this architecture remains unclear. Here, we report tyrosine kinase Abelson (Abl) fine-tunes by regulating endocytic trafficking. We show Abl can phosphorylate...