A5027157934- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Clusterin in disease pathology
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Growth Hormone and Insulin-like Growth Factors
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Prostate Cancer Treatment and Research
- Radiology practices and education
- Radiation Dose and Imaging
- Virus-based gene therapy research
- S100 Proteins and Annexins
- Immune cells in cancer
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Diversity and Career in Medicine
- Gastroesophageal reflux and treatments
- Cancer Research and Treatments
- Healthcare Policy and Management
- Peptidase Inhibition and Analysis
Center for Systems Biology
2018-2025
Massachusetts General Hospital
2018-2025
Harvard University
2014-2025
Dana-Farber Cancer Institute
2019-2025
Brigham and Women's Hospital
2014-2023
Boston University
2023
Boston Children's Hospital
2020-2021
The University of Texas Southwestern Medical Center
2021
Brown University
2006-2021
Pomona Valley Hospital Medical Center
2021
Tumor-associated macrophages (TAMs) are widely implicated in cancer progression, and TAM levels can influence drug responses, particularly to immunotherapy nanomedicines. However, it has been difficult quantify total numbers their dynamic spatiotemporal distribution a non-invasive translationally relevant manner. Here, we address this need by developing pharmacokinetically optimized,
Purpose To determine optimal parameters for acquisition and processing of dynamic contrast-enhanced MRI (DCE-MRI) to detect small changes in near normal low blood–brain barrier (BBB) permeability. Methods Using a contrast-to-noise ratio metric (K-CNR) Ktrans precision accuracy, the effects kinetic model selection, scan duration, temporal resolution, signal drift, length baseline on estimation permeability values was evaluated with simulations. Results The Patlak shown give highest K-CNR at...
Targeted inhibition of oncogenic pathways can be highly effective in halting the rapid growth tumors but often leads to emergence slowly dividing persister cells, which constitute a reservoir for selection drug-resistant clones. In BRAFV600E melanomas, RAF and MEK inhibitors efficiently block signaling, cells emerge. Here, we show that escape drug-induced cell-cycle arrest via brief, sporadic ERK pulses generated by transmembrane receptors factors operating an autocrine/paracrine manner....
Abstract The direct access of olfactory afferents to memory-related cortical systems has inspired theories about the role pathways in development neurodegeneration Alzheimer’s disease (AD). In this study, we used baseline identification measures with longitudinal flortaucipir and PiB PET, diffusion MRI 89 cognitively normal older adults (73.82 ± 8.44 years; 56% females), a transcriptomic data atlas investigate spatiotemporal spreading genetic vulnerabilities AD-related pathology aggregates...
Radionuclides used for imaging and therapy can show high molecular specificity in the body with appropriate targeting ligands. We hypothesized that local energy delivered by molecularly targeted radionuclides could chemically activate prodrugs at disease sites while avoiding activation off-target of toxicity. As proof principle, we tested whether this strategy radionuclide-induced drug engagement release (RAiDER) locally deliver combined radiation chemotherapy to maximize tumor cytotoxicity...
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a promising technique to characterize pathology and evaluate treatment response. However, analysis of DCE-MRI data complex benefits from concurrent multiple kinetic models parameters. Few software tools are currently available that specifically focuses on with models. Here, we developed ROCKETSHIP, an open-source, flexible modular for analysis. ROCKETSHIP incorporates analyses models, including data-driven nested model was...
Helper-dependent adenoviral vectors (HDAd) have been shown to mediate a considerably longer duration of transgene expression than first-generation vectors. We previously that from HDAd-transduced hepatocytes can persist at high levels for up 2.6 years in nonhuman primates following single-vector administration. Because and long-term toxicity are critical risk:benefit assessment, we continued monitor these animals. report here has persisted the entire observation period 7 all animals without...
Childbearing and Family Leave Policies
Ki-67 proliferation index (Ki-67 index) is used to quantify cell during histopathological assessment of various tumors including glioblastoma (GB).We aimed assess correlation between and overall survival in patients with GB determine a cut-point for that predicts poorer survival.Records adult diagnosed on specimens at tertiary cancer center Sydney 1 January 2002 30 July 2012 were retrieved. Specimens these examined quantification staining by two independent pathologists. Patient, disease,...
Parenting issues can affect physicians' choice of specialty or subspecialty, as well their selection individual training programs, because the distinctive challenges facing residents and fellows with children. Specific information about how perceive these is limited.
Abstract The Society of Nuclear Medicine and Molecular Imaging (SNMMI), founded in 1954, is an international scientific professional organization with a purpose to promote the science, technology, practical application nuclear medicine. European Association (EANM), 1985, nonprofit medical association facilitate communication among individuals medicine pursuing clinical academic excellence. Members SNMMI EANM are physicians, technologists, scientists who specialize research practice will...
With the increased use of focal radiation dose escalation for primary prostate cancer (PCa), accurate delineation gross tumor volume (GTV) in prostate-specific membrane antigen PET (PSMA-PET) becomes crucial. Manual approaches are time-consuming and observer dependent. The purpose this study was to create a deep learning model intraprostatic GTV PSMA-PET.
Radiotherapy is commonly used to treat cancer, and localized energy deposited by radiotherapy has the potential chemically uncage prodrugs; however, it been challenging demonstrate prodrug activation that both sustained in vivo truly tumors without affecting off-target tissues. To address this, we developed a series of novel phenyl-azide-caged, radiation-activated chemotherapy drug-conjugates alongside computational framework for understanding corresponding pharmacokinetic pharmacodynamic...
Helper-dependent adenoviral vectors (HDAds) are attractive for liver-directed gene therapy because they can mediate sustained, high-level transgene expression without chronic toxicity. However, high vector doses required to achieve efficient hepatic transduction by systemic delivery of a nonlinear dose response. Unfortunately, such result in dissemination and dose-dependent acute toxicity with potentially severe lethal consequences. We hypothesize that the threshold may be circumvented...
H.S. Thomsen and J.A.W. Webb, eds. Berlin, Germany: Springer-Verlag, 2009, 254 pages, $149 This second edition of Contrast Media: Safety Issues ESUR Guidelines provides new updated information on the contrast-related safety issues that a radiologist can encounter in daily practice.
Interpreting how multicellular interactions in the tumor affect resistance pathways to BRAF and MEK1/2 MAPK inhibitors (MAPKi) remains a challenge. To investigate this, we profiled global ligand-receptor among stromal/immune cells from biopsies of MAPK-driven disease. MAPKi increased tumor-associated macrophages (TAMs) some patients, which correlated with poor clinical response, coamplified bidirectional tumor-TAM signaling via receptor tyrosine kinases (RTKs) including AXL, MERTK, their...
Abstract Therapeutic nucleic acid delivery has many potential applications, but it remains challenging to target extrahepatic tissues in a flexible and image-guided manner. To address this issue, we report bioorthogonal pre-targeting strategy that uses focused ultrasound promote the of mRNA-loaded lipid nanoparticles (mRNA-LNP). We synthesized amphiphilic click reactive anchors (ACRAs) consisting phospholipid PEG-conjugate functionalized with transcyclooctene (TCO) or its companion partner...
215 Background: Radioligand therapy targeting prostate-specific membrane antigen (PSMA), such as 177 Lu-PSMA-617, has demonstrated clinical efficacy in PSMA-PET-positive metastatic castration-resistant prostate cancer (mCRPC). However, not all PSMA-positive mCRPC patients benefit from this therapy, highlighting the need for novel biomarkers to predict treatment response. We aimed evaluate whether molecular analysis of circulating tumor cells (CTCs) could provide predictive Lu-PSMA-617...
ABSTRACT Background 177 Lu‐vipivotide tetraxetan ( Lu‐PSMA‐617, LuPSMA) improves overall survival in patients with metastatic castration‐resistant prostate cancer (mCRPC) after at least one taxane chemotherapy and androgen receptor pathway inhibitor. There are limited data on the clinical course outcomes of mCRPC receipt LuPSMA. Methods We queried an IRB‐approved prospectively maintained registry all who received standard‐of‐care LuPSMA our institution between June 2022 January 2024....
Noninvasive methods are needed to explore the heterogeneous tumor microenvironment and its modulation by therapy. Hybrid PET/MRI systems being developed for small-animal clinical use. The advantage of these integrated depends on their ability provide MR images that spatially coincident with simultaneously acquired PET images, allowing combined functional MRI studies intratissue heterogeneity. Although much effort has been devoted developing this new technology, issue quantitative spatial...