A5037195356- Celiac Disease Research and Management
- Microscopic Colitis
- Gastrointestinal disorders and treatments
- Gastrointestinal Bleeding Diagnosis and Treatment
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Digestive system and related health
- Colorectal Cancer Screening and Detection
- Gastrointestinal motility and disorders
- Gastric Cancer Management and Outcomes
- Clinical Nutrition and Gastroenterology
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Child Nutrition and Feeding Issues
- Intestinal Malrotation and Obstruction Disorders
- Gastroesophageal reflux and treatments
- Dysphagia Assessment and Management
- Pancreatitis Pathology and Treatment
- Nutrition and Health in Aging
- Microbial Metabolites in Food Biotechnology
- Diverticular Disease and Complications
- Pancreatic and Hepatic Oncology Research
- Whipple's Disease and Interleukins
- Palliative Care and End-of-Life Issues
Sheffield Teaching Hospitals NHS Foundation Trust
2016-2025
University of Sheffield
2016-2025
National Health Service
2010-2025
Kelowna General Hospital
2023-2025
Royal Hallamshire Hospital
2015-2024
University of British Columbia
2018-2024
University of Edinburgh
2023
Wythenshawe Hospital
2023
Chesterfield Royal Hospital NHS Foundation Trust
2023
NIHR Clinical Research Network
2022
<h3>Objective</h3> The literature suggests a lack of consensus on the use terms related to coeliac disease (CD) and gluten. <h3>Design</h3> A multidisciplinary task force 16 physicians from seven countries used electronic database PubMed review for CD-related up January 2011. Teams then suggested definition each term, followed by feedback these definitions through web survey definitions, discussions during meeting in Oslo phone conferences. In addition ‘CD’, following descriptors CD were...
A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway the USA) reviewed literature on diagnosis management adult coeliac disease (CD). This paper presents recommendations British Society Gastroenterology. Areas controversies were explored through phone meetings web surveys. Nine working groups examined following areas CD management: classification CD; genetics immunology; diagnostics; serology endoscopy;...
This Guideline is an official statement of the European Society Gastrointestinal Endoscopy (ESGE). The was also reviewed and endorsed by British Gastroenterology (BSG). It addresses roles small-bowel capsule endoscopy device-assisted enteroscopy for diagnosis treatment disorders. <b>Main recommendations</b> <b>1</b> ESGE recommends video as first-line investigation in patients with obscure gastrointestinal bleeding (strong recommendation, moderate quality evidence). <b>2</b> In overt...
This guideline presents recommendations for the management of coeliac disease (CD) and other gluten-related disorders both in adults children. There has been a substantial increase prevalence CD over last 50 years many patients remain undiagnosed. Diagnostic testing, including serology biopsy, should be performed on gluten-containing diet. The diagnosis is based combination clinical, serological histopathological data. In group children may made without biopsy if strict criteria are...
This Guideline is an official statement of the European Society Gastrointestinal Endoscopy (ESGE). It addresses diagnosis and management nonvariceal upper gastrointestinal hemorrhage (NVUGIH). <b>Main Recommendations</b> <b>MR1.</b> ESGE recommends immediate assessment hemodynamic status in patients who present with acute (UGIH), prompt intravascular volume replacement initially using crystalloid fluids if instability exists (strong recommendation, moderate quality evidence). <b>MR2.</b> a...
Non-Celiac Gluten Sensitivity (NCGS) is a syndrome characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected either celiac disease or wheat allergy. Given lack NCGS biomarker, there need for standardizing procedure leading diagnosis confirmation. In this paper we report experts’ recommendations on how diagnostic protocol should be performed confirmation NCGS. A full assess clinical response gluten-free diet...
MR1: ESGE recommends small-bowel capsule endoscopy as the first-line examination, before consideration of other endoscopic and radiological diagnostic tests for suspected bleeding, given excellent safety profile endoscopy, its patient tolerability, potential to visualize entire mucosa.Strong recommendation, moderate quality evidence. MR2: in patients with overt bleeding soon possible after episode, ideally within 48 hours, maximize subsequent therapeutic yield.Strong high MR3: does not...
Percutaneous endoscopic gastrostomy (PEG) feeding has been validated in specific clinical situations such as acute stroke with dysphagia and oropharyngeal malignancy. The perception that insertion is safe technically simple led to an increase the demands for PEG insertion, encompassing applications patients dementia, whom its role not justified. purpose of this study was compare mortality dementia who were fed by other subgroups requiring feeding.The focused on a cohort 361 consecutive...
Objectives To establish the prevalence of coeliac disease in general population and specific conditions, such as irritable bowel syndrome, iron deficiency anaemia, fatigue other coeliac-related conditions. Methods Primary-care-based cross-sectional study using immunoglobulins, IgA/IgG antigliadin antibodies endomysial to initially recognize disease. A total 1200 volunteers were recruited from January 1999 June 2001 five practices South Yorkshire, UK. Any participant with a positive IgA...
1.0 Introduction 2.0 Formulation of guidelines 2.1 Grading recommendations 2.2 Scheduled review 3.0 Summary recommendations 4.0 Types small bowel enteroscopy 4.1 Enteroscopy using a colonoscope 4.2 Sonde enteroscopy 4.3 Push enteroscopy 4.4 Intraoperative enteroscopy 4.5 Double balloon (push and pull) enteroscopy 5.0 Capsule endoscopy 5.1. Technique 5.2 Indications for capsule endoscopy 5.3 Complications endoscopy 5.4 Patency capsule 6.0 Service provision...
Abstract Objective Gluten sensitivity typically presents as celiac disease, a chronic, autoimmune‐mediated, small‐intestinal disorder. Neurological disorders occur with frequency of up to 10% in these patients. However, neurological dysfunction can also be the sole presenting feature gluten sensitivity. Development autoimmunity directed toward different members transglutaminase gene family could offer an explanation for diversity manifestations We have identified novel neuronal isozyme and...
<b>Background:</b> Diminutive and flat colorectal lesions can be difficult to detect using conventional colonoscopic techniques. Previous data have suggested that pan-chromoscopy may improve detection rates. No randomised control trial has been performed examining rates of such while controlling for extubation time lavage effect. <b>Aim:</b> We conducted a controlled pan-colonic chromoscopic colonoscopy the diminutive <b>Methods:</b> Consecutive patients attending routine were either 0.5%...
To investigate the presence of autoantibody deposition against type 2 tissue transglutaminase (TG2; a reliable marker whole spectrum gluten sensitivity) in jejunal and brain patients with ataxia control subjects.The authors evaluated biopsy samples from nine seven other causes for TG2-related immunoglobulin deposits using double-color immunofluorescence. Autopsy one patient neurologically intact were also studied.IgA on TG2 was found all none controls. The intestinal IgA pattern similar to...
Background Reports suggest that gluten sensitivity (GS) exists in the absence of coeliac disease (CD). This clinical entity has been termed noncoeliac (NCGS). Objectives To determine population prevalence self-reported GS and referral characteristics to secondary care. Patients methods A UK population-based questionnaire screened for related symptoms. Diagnostic outcomes were also analyzed patients referred care with GS. CD diagnosis entailed a positive serology (endomysial and/or tissue...
<h3>Objective:</h3> Our previous coeliac disease genome-wide association study (GWAS) implicated risk variants in the human leucocyte antigen (HLA) region and eight novel regions. To identify more loci, we selected 458 single nucleotide polymorphisms (SNPs) that showed modest GWAS for genotyping analysis four independent cohorts. <h3>Design:</h3> SNPs were assayed 1682 cases 3258 controls from three populations (UK, Irish Dutch). We combined results with original cohort (767 UK 1422...
A shortfall exists of female doctors in senior academic posts the United Kingdom. Career progression depends on measures esteem, including publication prestigious journals. This study investigates gender differences first and authorship six peer-reviewed British journals factors that are associated with rates.Data was collected Kingdom authors who had published Medical Journal, Lancet, Journal Surgery, Gut, Obstetrics Gynaecology Archives Diseases Childhood. Authorship were quantified for...