A5020274082- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Family Support in Illness
- Ethics in medical practice
- Genetics and Neurodevelopmental Disorders
- Ethics in Clinical Research
- Cancer Genomics and Diagnostics
Cedars-Sinai Medical Center
2022
Sinai Health System
2020
Stanford University
2018
Abstract Background Women harboring mutations in breast cancer susceptibility genes are at increased lifetime risk of developing and faced with decisions about management, including whether to undergo high‐risk screening or risk‐reducing mastectomy (RRM). National guidelines recommend BRCA1 BRCA2 mutation carriers consider RRM, but that moderate penetrance (e.g., ATM CHEK2 ) should be managed based on family history. We aimed investigate determinants decision for hypothesized status, age,...
Abstract BACKGROUND: Germline genetic testing is routinely incorporated into clinical care for breast cancer patients to inform management decisions and reduce risk developing subsequent cancers. While the diagnostic yield of has increased over years due adoption multigene panels, a substantial portion remain without molecular diagnosis yet are suspected have mutation that could not be detected and/or classified with standard DNA techniques. We assessed ability novel approach involving...