A5036032867- Head and Neck Cancer Studies
- Ear Surgery and Otitis Media
- Connexins and lens biology
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Parasitic Diseases Research and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Mosquito-borne diseases and control
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Nicotinic Acetylcholine Receptors Study
- Management of metastatic bone disease
- Cholangiocarcinoma and Gallbladder Cancer Studies
- NF-κB Signaling Pathways
- Cancer-related Molecular Pathways
- Hearing, Cochlea, Tinnitus, Genetics
- Esophageal Cancer Research and Treatment
- Oral health in cancer treatment
- Phonetics and Phonology Research
- HER2/EGFR in Cancer Research
- Reconstructive Facial Surgery Techniques
- Molecular Biology Techniques and Applications
- Facial Nerve Paralysis Treatment and Research
- Neuroendocrine Tumor Research Advances
- Vestibular and auditory disorders
Semmelweis University
2011-2024
Despite great enthusiasm towards immunotherapy, reliable biomarkers are still lacking. The importance of subsets based on human papillomavirus (HPV) status is supported by a growing body evidence. However, role other possible subgroups such as anatomic localization primary tumor remains controversial. Our objective was to investigate immune cell infiltrate and checkpoint inhibitor proteins in above-mentioned head neck cancer subsets. Archival samples 106 laryngeal, oropharyngeal,...
Abstract Purpose The presence of cervical lymph node metastases is one the most influential prognostic factors in head and neck squamous cell carcinomas. management clinically N0 patients with cancer remains controversial: elective dissection has relatively high morbidity, adversely affecting quality life, however, abandoning known to compromise overall survival numerous primaries. purpose this study was evaluate accuracy conventional imaging modalities (CT, MRI, US) fine-needle aspiration...
The survival benefit with higher body mass index (BMI) of patients suffering from head and neck squamous cell carcinoma (HNSCC) is documented as BMI paradox. As the early re-nourishment high-risk determine survival, we searched for a nutritional status marker suitable everyday screening. Grouping based on 8th Edition TNM Classification, investigated first time candidate markers among TNM8 subgroups, including newly introduced p16 positive oropharyngeal cancer (OPSCC) patients.
Gap juctions are transmembrane communication channels known to be involved in the control of cell proliferation by mediating exchange ions and small molecules between cells. junctions composed connexon hemichannels made up 6 connexin proteins, which abnormal expression functions have been linked tumor progression poorer prognosis. Here, we studied prognostic impact most prevalent isotype, 43 (Cx43) head neck squamous carcinomas (HNSCC). Tissue microarrays from samples 90 HNSCC patients were...
The poor prognosis of head-and-neck squamous cell carcinoma (HNSCC) is partly due to the lack reliable prognostic and predictive markers. Ras/Raf/MEK/ERK signaling pathway often activated by overexpressed epidermal growth factor receptor (EGFR) stimulates progression HNSCCs. Our research was performed on three human papillomavirus (HPV)-negative HNSCC-cell lines: Detroit 562, FaDu SCC25. Changes in viability upon EGFR and/or MEK inhibitors were measured MTT method. protein-expression...
Abstract Purpose Our aim was to determine whether perioperatively administered corticosteroid treatment has any beneficial effect on the outcome of stapes surgery, with special regard audiological results and early postoperative morbidity. Methods 84 CO 2 laser stapedotomies performed in our institute between 2013 2018 were included investigation. All cases underwent preoperative mid-term pure-tone audiometric evaluation. Vestibular complications also evaluated. The subdivided into two...
The poor prognosis of head and neck squamous cell carcinoma (HNSCC) is partly due to the lack reliable predictive markers. Connexin 43 (Cx43) protein its cell-communication channels have been assigned tumor suppressor functions while anti-apoptotic Bcl-2 (B-cell lymphoma-2) has associated with negative prognostic significance in cancer. This study aimed test role Cx43 on expression, progression response taxane-based treatment HNSCC. Human papillomavirus (HPV) HNSCC lines were tested for...
To evaluate the efficacy of ossicular chain reconstruction (OCR) in primary and revision surgeries, to investigate impact number previous surgeries on hearing outcomes.Retrospective analysis cases with OCR due chronic otitis a tertiary center between January 2018 September 2021.Altogether, 147 ossicle involvement were assessed. In 91.83% (n = 135) was performed, 96.26% them titanium TORP/PORP 130), two autologous prosthesis three piston. Mean follow-up 8.8 months. The ABG significantly...
Introduction: Head and neck cancers represent a major health problem in Hungary. With their high incidence mortality rates, Hungary is one of the world leaders these indicators. The length patient delay, defined as time from onset symptoms to first medical consultation, unknown Hungarian patients with head cancer. We aimed use representative sample cancer population determine delay according disease localization stage identify correlations other clinical parameters. Methods: In our...
Head and neck squamous cell carcinomas (HNSCC) are among the most common malignancies in men worldwide. Nevertheless, their clinical management is hampered by limited availability of reliable predictive prognostic biomarkers. Protein kinase D (PKD) isoforms contribute to major cellular processes. However, potential role HNSCC has not been studied systematically, which focus this study. A total 63 therapy-naive patients with carcinoma were consecutively enrolled. Tissue microarray duplicate...
Abstract: Dirofilariasis refers to an infection caused by a specific parasitic roundworm. Dirofilaria repens – transmitted mosquito bites accounts for most human cases. The parasite forms subcutaneous mass called cutaneous dirofilariasis near the original site of intrusion. incidence infections shows increasing tendency. We report case 35-year-old woman presenting with three-week history painful swelling in temporal region. initial diagnostic work-up revealed roundworm embedded fat tissue...