A5028808699- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Antibiotic Resistance in Bacteria
- Artificial Intelligence in Healthcare and Education
- Mycobacterium research and diagnosis
- Academic integrity and plagiarism
- Tuberculosis Research and Epidemiology
- Clinical Reasoning and Diagnostic Skills
- CRISPR and Genetic Engineering
Swansea University
2025
University of Liverpool
2021-2022
University of Leeds
2021-2022
Institute of Structural and Molecular Biology
2021
Pseudomonas aeruginosa undergoes diversification during infection of the cystic fibrosis (CF) lung. Understanding these changes requires model systems that capture complexity CF lung environment. We previously identified loss-of-function mutations in 2-component regulatory system sensor kinase gene pmrB P. from infections and experimental mice. Here, we demonstrate that, while such lowered vitro minimum inhibitory concentrations for multiple antimicrobial classes, this was not reflected...
A greater understanding of the genes involved in antibiotic resistance Mycobacterium tuberculosis (Mtb) is necessary for design improved therapies. Clustered regularly interspaced short palindromic repeat interference (CRISPRi) has been previously utilized mycobacteria to identify novel drug targets by demonstration gene essentiality. The work presented here shows that it can also be usefully applied study non-essential resistance. expression an ADP-ribosyltransferase (Arr) rifampicin...
Abstract Pseudomonas aeruginosa undergoes diversification during infection of the cystic fibrosis (CF) lung. Understanding these changes requires model systems that capture complexity CF lung environment. We previously identified loss-of-function mutations in two-component regulatory system sensor kinase gene pmrB , P. from and experimental mice. Here, we demonstrate whilst such lower vitro MICs for multiple antimicrobial classes, this is not reflected increased antibiotic susceptibility...