A5101401493- Viral-associated cancers and disorders
- Histiocytic Disorders and Treatments
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Cutaneous lymphoproliferative disorders research
- Telomeres, Telomerase, and Senescence
- Genetics, Aging, and Longevity in Model Organisms
- Extracellular vesicles in disease
- Muscle metabolism and nutrition
- Pediatric Pain Management Techniques
- Pain Management and Opioid Use
- Regulation of Appetite and Obesity
- Tumors and Oncological Cases
Westmead Institute for Medical Research
2024
Zhejiang University
2008-2022
Zhejiang Museum of Natural History
2022
The University of Texas MD Anderson Cancer Center
2017
Dendritic cell sarcomas are rare tumours of antigen presenting cells. Data regarding their biology, management and outcomes sparse. We analysed 66 patients with follicular dendritic sarcoma (FDCS). Six also had Castleman disease, 9 another malignancy 13 an autoimmune disease. Fifty-four per cent presented localized disease 46% systemic involvement. The median progression-free (PFS) overall survival (OS) following frontline therapy was 21 50 months, respectively. Survival were significantly...
Rosai-Dorfman disease (RDD) is an idiopathic histiocytic proliferation affecting the lymph nodes. Isolated intracranial RDD rare and usually appears as a well-defined, dural-based lesion without lymphadenopathy. The clinical radiological features of are similar to meningioma. Histopathology immunohistochemistry essential for definitive diagnosis. This report 43-year old male with isolated RDD, which manifested suprasellar clinical, pathological aspects discussed within context review...
Abstract Disclosure: J. Yu: None. C. Cheung: J.E. Gunton: Exercise is well-established to be beneficial for obesity, type 2 diabetes (T2D) and cardiovascular health. induces hypoxia inducible factor 1α (HIF1α) in muscle. HIF1α well-known its role cell survival adaptation, particularly states of hypoxia. Interestingly, obesity diabetes, can exert either or harmful effects (1). We hypothesised that these differing outcomes may relate different hydroxylation HIF1α. Using CRISPR-Cas9 technology,...
Lifespan is a life-history trait that undergoes natural selection. Telomeres are hallmarks of aging, and shortening rate predicts species lifespan, making telomere maintenance mechanisms throughout different lifespans worthy topic for study. Alligators suitable the exploration anti-aging molecular mechanisms, because they exhibit low or even negligible mortality in adults no significant shortening. Telomerase reverse transcriptase (TERT) expression absent adult Alligator sinensis, as humans....