A5074286061- Electroconvulsive Therapy Studies
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Rabies epidemiology and control
- Neural and Behavioral Psychology Studies
- Mental Health Treatment and Access
- Diphtheria, Corynebacterium, and Tetanus
- Anesthesia and Sedative Agents
- Neurological disorders and treatments
- Transcranial Magnetic Stimulation Studies
- Mental Health Research Topics
- Bartonella species infections research
- Digital Mental Health Interventions
- Acne and Rosacea Treatments and Effects
- Bariatric Surgery and Outcomes
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Autism Spectrum Disorder Research
- COVID-19 and healthcare impacts
- Metastasis and carcinoma case studies
- Takotsubo Cardiomyopathy and Associated Phenomena
- Connexins and lens biology
- Body Image and Dysmorphia Studies
Hamad Medical Corporation
2020-2024
University of Aberdeen
2006-2022
Royal Cornhill Hospital
2012-2017
NHS Grampian
2017
Stracathro Hospital
2015
Royal Aberdeen Children's Hospital
2007
University of Edinburgh
2001
Columbia University Irving Medical Center
1992
New York University
1992
Bristol Royal Infirmary
1992
To date, electroconvulsive therapy (ECT) is the most potent treatment in severe depression. Although ECT has been successfully applied clinical practice for over 70 years, underlying mechanisms of action remain unclear. We used functional MRI and a unique data-driven analysis approach to examine connectivity brain before after treatment. Our results show that lasting effects on architecture brain. A comparison pre- posttreatment data group nine patients revealed significant cluster voxels...
How does a neuron, challenged by an increase in synaptic input, display response that is independent of the initial level activity? Here we show both oxytocin and vasopressin cells supraoptic nucleus normal rats respond to intravenous infusions hypertonic saline with gradual, linear increases discharge rate. In hyponatremic rats, also responded linearly but much lower slopes. The linearity was surprising, given expected nonlinearity neuronal behavior secretory such infusions. We simple...
Background Electroconvulsive therapy (ECT) is an effective treatment for depression but the extent and persistence of cognitive side-effects remain uncertain. It has been reported that there little evidence impairments last longer than up to 15 days post-ECT. However, relatively few studies have followed patients even as long 1 month Here we report results from a brief battery given prior ECT repeated five times 6 months Method In retrospective case-note study routinely collected clinical...
BackgroundKetamine has recently become an agent of interest as acute treatment for severe depression and the anaesthetic electroconvulsive therapy (ECT). Subanaesthetic doses result in reduction severity while evidence is equivocal this antidepressant effect with or adjuvant doses. Recent systematic reviews call high-quality from further randomised controlled trials (RCTs).AimsTo establish if ketamine ECT results fewer treatments, improvements ratings less memory impairment than standard...
When the blood serum of one animal is injected into an a different species in many instances appears to take no hurt. If however after certain interval experiment repeated, it has been noted that may speedily show evidence physical disturbance. Its breathing becomes rapid: its heart-beat grows feeble: limbs move spasmodically and general convulsions ensue. These phenomena have taken indicate supersensitized —or rendered abnormally sensitive—to employed. They attain such gravity dies. It...
Abstract Objectives Lifetime DSM‐5 diagnoses generated by the lay‐administered Composite International Diagnostic Interview for (CIDI) in World Mental Health Qatar (WMHQ) study were compared to based on blinded clinician‐administered reappraisal interviews. Methods Telephone follow‐up interviews used non‐patient edition of Structured Clinician (SCID) oversampling respondents who screened positive five CIDI: major depressive episode, mania/hypomania, panic disorder, generalized anxiety and...
Studies were conducted to determine whether accumulation of the scrapie agent protein Sp33–37 in brain correlated with appearance or pathology. The concentrations and measured purified fraction P5 isolated from hamster brains at weekly intervals after inoculation. concentration was approximately 10−1 LD50/g 1 day post-inoculation increased 109.4LD50/g 77. first detected 21, when titre 103.9 LD50/g. concert concentration, although apparent rate increase somewhat lower for than agent....
Electroconvulsive therapy (ECT) is held to confer anticonvulsant effects, although the role of rise in seizure threshold upon clinical effect uncertain. This study investigated relationship a large, consecutive, retrospective sample patients receiving ECT Aberdeen. We have tested hypotheses previous authors further examine between and therapeutic as well discuss potential underlying neurobiological mechanisms.All at Royal Cornhill Hospital 2000 end 2008 were identified from Scottish...
To define the neuropsychological deficits present in mild human immunodeficiency virus type 1 (HIV-1) associated with acquired syndrome (AIDS) dementia complex (ADC) and to develop a rational test battery for its diagnosis.Survey.Subjects were recruited from large metropolitan hospital outpatient clinics all living independently general community.Three volunteer samples of homosexual-bisexual men: (1) 15 patients who met clinical research criteria ADC; (2) 27 HIV-seronegative (HIV-)...
The following general statements are applicable to the 50 cases of cerebrospinal fever which have been under notice here. total volume serum given did not affect frequency abnormal reactions. number injections serum, in certain cases, may a factor inducding interval time between concerned was primary influence determining It apparent that preceding normal reaction predisposed subsequent reaction. large administration within latent period
Abstract Background The Composite International Diagnostic Interview (CIDI) has been clinically reappraised in several studies conducted mainly the US and Europe. This report describes methodology used to conduct one of Middle East's largest clinical reappraisal studies. study was carried out conjunction with World Mental Health Qatar—the first national psychiatric epidemiological common mental disorders country. aimed evaluate diagnostic consistency core modules newly translated adapted...
Abstract Neurodevelopmental and neurodegenerative pathology occur in Schizophrenia. This study compared the utility of corneal confocal microscopy (CCM), an ophthalmic imaging technique with MRI brain volumetry quantifying neuronal its relationship to cognitive dysfunction symptom severity schizophrenia. Thirty-six subjects schizophrenia 26 controls underwent assessment function, severity, CCM volumetry. Subjects had lower function (P ≤ 0.01), nerve fiber density (CNFD), length (CNFL),...
The study aimed to explore cognitive outcomes after electroconvulsive therapy (ECT) depending on which version of common single nucleotide polymorphisms the patient expressed for brain-derived neurotrophic factor (BDNF) and catechol-O-methyltransferase (COMT).A total 87 patients from clinical ECT service in Aberdeen, Scotland, were included study. Cognitive function testing (using Spatial Recognition Memory task Cambridge Neuropsychological Test Automated Battery Mini-Mental State...
Since the close of period which furnished data for preceding paper regarding effects repeated injections horse serum, two cases have been observed in practice Belvidere Fever Hospital special bearing on subject abnormal rashes after suitably doses antidiphtherial serum.
Published evidence about the impact of COVID-19 pandemic on Obsessive-Compulsive Disorder (OCD) is conflicting. Most studies suggest an increase in severity OCD people with pre-existing OCD, whereas some do not.Given conflicting globally and lack data from Arab world, we aimed to explore obsessive-compulsive symptoms adults OCD.A telephonic questionnaire-based cross-sectional study among specifically fear contamination washing compulsions being major symptom dimensions OCD. The during was...
A questionnaire survey of anaesthetists, based at the three main hospitals in Bristol, was undertaken to determine what methods are currently being used by anaesthetists manage diabetes patients for surgery. Replies were received from 56 90 (62%). Surgical procedures defined as minor, moderate, and major. Two areas identified where considerable differences management between occurred, namely insulin-treated requiring minor surgery, non-insulin-treated moderate In addition, no consensus view...
This study describes the relationship between socioeconomic deprivation and electroconvulsive therapy (ECT) prescription outcomes. Two research questions are addressed in this study: (1) Does rate of ECT increase with deprivation? (2) influence outcomes? Electroconvulsive outcomes, consecutive patients from Aberdeen, were compared across groups determined by Scottish Index Multiple Deprivation (SIMD) quintiles. A primary care sample, invited to complete Hospital Anxiety Depression Scale...