A5062342341- Parkinson's Disease Mechanisms and Treatments
- Lysosomal Storage Disorders Research
- Neurological diseases and metabolism
- Atrial Fibrillation Management and Outcomes
- Venous Thromboembolism Diagnosis and Management
- Sleep and related disorders
- Autism Spectrum Disorder Research
- Urban Transport and Accessibility
- Sleep and Wakefulness Research
- Cellular transport and secretion
- Acute Ischemic Stroke Management
- RNA Research and Splicing
- Retinal Development and Disorders
- Glycogen Storage Diseases and Myoclonus
- Children's Physical and Motor Development
- Neurogenetic and Muscular Disorders Research
- Circadian rhythm and melatonin
- Nuclear Receptors and Signaling
- Assistive Technology in Communication and Mobility
- Metabolism and Genetic Disorders
- Medical Coding and Health Information
- Neurological disorders and treatments
- RNA regulation and disease
- Electronic Health Records Systems
- Alzheimer's disease research and treatments
Icahn School of Medicine at Mount Sinai
2022-2024
Mount Sinai Beth Israel
2023-2024
University of Milan
2022
Ospedale Maggiore
2022
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2022
Tel Aviv Sourasky Medical Center
2022
Mount Sinai Health System
2020
Columbia University Irving Medical Center
2017
Columbia University
2014-2016
Recent research has suggested a possible link between Parkinson's disease (PD) and Fabry disease. To test this relationship, we administered self-report family history questionnaire to determine the prevalence of PD in patients members with likely pathogenic alpha-galactosidase A (GLA) mutations. total 90 (77 from online survey 13 Icahn School Medicine at Mount Sinai (ISMMS)) were included analysis. Two who completed diagnosed (2/90, 2.2%). Among probands older than 60, 8.3% (2/24) PD. Using...
Carbidopa-levodopa has been used for more than 50 years in the treatment of Parkinson disease (PD) and other movement disorders. Pyridoxal 5'-phosphate (PLP), an active form vitamin B6 (pyridoxine), is involved decarboxylation levodopa to dopamine; carbidopa, which combined with reduce peripheral conversion minimize dopamine side effects, binds irreversibly PLP. As a result, carbidopa-levodopa may cause deficiency associated sequelae, including seizures, especially high doses. A 78-year-old...
variants have been associated with immune dysregulation as well immune-related disorders such IBD. A possible relationship between multiple sclerosis (MS) and
Parkinson disease is a chronic and multifaceted neurodegenerative disorder that necessitates specialized integrated care. By engaging with multidisciplinary team, including movement disorders specialist, physical therapist, speech-language pathologist, occupational dietician social worker, patients may become familiar and, eventually, adept at skills have the potential to improve quality of life. Many feel overwhelmed by plurality providers involved in management their long-term condition....
Dating back to ancient civilizations when records were carefully transcribed onto papyrus, clinical documentation has long served as a cornerstone of medical-and especially neurologic-education. From the case histories Hippocrates diurnal patient logs used by trainees in 18th and 19th centuries, notes have an extended history invaluable instruments pedagogy, scholarly practice, interprofessional communication. The novel paradigm introduced Lawrence Weed 1950s, advocating for problem-oriented...
Molecular therapies exploit the understanding of pathogenic mechanisms to reconstitute impaired gene function or manipulate flawed RNA expression. These include (1) interference by antisense oligonucleotides, (2) mRNA modification using small molecules, and (3) replacement therapy, viral-mediated intracellular delivery exogenous nucleic acids reverse a genetic defect. Several molecular are approved for treating spinal muscular atrophy (SMA), recessive disorder caused survival motor neuron...
<h3>Objective:</h3> To assess the effects of a short-term tailored lighting intervention therapy (TLI) on sleep disturbances in Parkinson disease (PD). <h3>Background:</h3> Sleep are common non-motor symptom PD, adversely affecting quality life, mood and cognition. They suggest underlying disruptions circadian rhythm. Based our preliminary studies showing positive impacts TLI sleep, behavior Alzheimer's disease, we hypothesize that can improve objective measures PD. <h3>Design/Methods:</h3>...