A5000245598- Tryptophan and brain disorders
- Stress Responses and Cortisol
- COVID-19 and Mental Health
- Stress and Burnout Research
- Maternal Mental Health During Pregnancy and Postpartum
- Resilience and Mental Health
- Mental Health Research Topics
- Treatment of Major Depression
- Health, psychology, and well-being
- Long-Term Effects of COVID-19
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Bipolar Disorder and Treatment
- Health and Lifestyle Studies
- Advanced Neuroimaging Techniques and Applications
- Heart Rate Variability and Autonomic Control
- Child Abuse and Trauma
- Aging, Health, and Disability
- Medical research and treatments
- Healthcare professionals’ stress and burnout
- Mental Health Treatment and Access
- Transcranial Magnetic Stimulation Studies
- COVID-19 Pandemic Impacts
- Psychological Treatments and Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Public Health and Environmental Issues
Central Institute of Mental Health
2022-2025
Heidelberg University
2022-2025
University Hospital Heidelberg
2023-2025
Universidad Peruana Cayetano Heredia
2011-2024
German Center for Diabetes Research
2024
Justus-Liebig-Universität Gießen
2019-2023
Medical University of Lublin
2023
Giessen School of Theology
2023
Weatherford College
2023
University Medical Center Freiburg
2023
Inflammatory processes have been implicated in the pathophysiology of depression. In human studies, inflammation has shown to act as a critical disease modifier, promoting susceptibility depression and modulating specific endophenotypes However, there is scant documentation how inflammatory are associated with neural activity patients We therefore tested hypothesis that peripheral markers IL-6 TNF-α correlate resting state network functional connectivity using magnetic resonance imaging...
Abstract The aim of this work was to investigate differences between depressed subjects (PG) and non-depressed healthy control participants (HCG) with regard fatigue dimensions inflammation. For purpose, 43 in the PG 51 HCG were included study. IL-6, IL-1β, TNF-α, IFN-γ, CRP assessed venous blood samples. Fatigue depression using FIS-D BDI-FS questionnaires. Main results showed higher values PG. Moreover, mean for when compared HCG. pro-inflammatory markers, a moderate group effect found...
Abstract Tryptophan breakdown metabolites formed along the kynurenine pathway play a significant role in pregnancy and fetal development. To understand their involvement, it is crucial to quantify levels of tryptophan (TRP), (KYN), kynurenic acid (KYNA) relevant biological samples such as placenta, membranes, umbilical cord. This study used liquid chromatography-tandem mass spectrometry (LC–MS/MS) determine TRP, KYN, KYNA levels. The LC–MS/MS method was optimized for high sensitivity...
Systemic sclerosis (SSc), a predominantly female-affected systemic autoimmune disease, requires tailored treatment strategies contingent on organ involvement and symptom severity. Given SSc's inflammatory nature, the of kynurenine pathway (KP) in its pathophysiology is underexplored. Our study aimed to investigate sex-related differences KP activation among SSc patients assess impact angiotensin-converting enzyme (ACE) inhibitors estimated glomerular filtration rate (eGFR) metabolite...
Background Neuroinflammatory processes in depression are associated with treatment resistance to conventional antidepressants. Ketamine is an effective new therapeutic option for treatment-resistant (TRD). Its well-established immunomodulatory properties hypothesized mediate its antidepressant effect. In this context, higher levels of inflammation may predict a better response. However, conclusive evidence hypothesis lacking. We thus investigated whether standard peripheral inflammatory cell...
Background: COVID-19 has created a rapid onset health crisis severely affecting different countries, such as Peru. This pandemic also involved social changes, the lockdown, which had negative effects on aspects of peoples’ mental health. For this reason, main objective work is to establish model that explains COVID-19-lockdown period population sample in Methods: In sense, online questionnaires were carried out using PHQ-9, GAD-7, and CPDI 400 participants. To better explain data, an ordinal...
Abstract We admitted a 42‐year‐old patient with severe treatment‐resistant depression and psychiatric comorbidities. The attempted suicide 5 weeks after admission. Subsequently, we initiated dextromethorphan/bupropion based on prior evidence. As result, the demonstrated an improvement in mood symptoms reduction risk, leading to her discharge.
Objetivo: Efectuar una validación de contenido por expertos del Índice Distrés Peri-traumático relacionado a COVID-19 (CPDI) para su uso en el Perú. Material y Métodos: El CPDI fue traducido al castellano luego adaptado primera ronda expertos. En segunda (n = 13), se evaluó la validez mediante V Aiken (V). Se calculó cada ítem, así como instrumento conjunto (V TOT). Resultados: De los 24 ítems originales, solo un ítem (S7) presentó valores no significativos contenido, razón que eliminado. La...
Abstract The main objective of this study was to evaluate the effect left anodal transcranial direct current stimulation (tDCS) on hypothalamic–pituitary–adrenal axis (HPAA) activity in individuals with depression. We conducted a 3-week, randomized, triple-blind pilot trial 47 participants (dropout rate: 14.89%) randomly assigned either tDCS or control group (sham stimulation). Salivary cortisol used as an HPAA marker since is effector hormone HPAA. primary outcome diurnal pattern (DCP and...
At the maternal-fetal interface in pregnancy, stress during pregnancy can lead to an increased vulnerability later psychopathology of fetus. Potential mediators this association have scarcely been studied and may include early alterations fetal brain-derived neurotrophic factor (BDNF). Amniotic fluid is particular interest for effects on endocrine alterations, as assessment amniotic allows measurements over a time integral. This study hypothesized that maternal psychometrics, socioeconomic...
Se examina el fenómeno clínico conocido como “fatiga”, resumiendo los principales hallazgos vinculados a su definición y aspectos históricos, información epidemiológica, conceptos neuroanatómicos descripción psicopatológica. Las correlaciones entre distintos tipos de daño estructural funcional son numerosas generando dudas en torno la existencia del síntoma planteándose entonces una redefinición. La búsqueda mecanismos fisiopatológicos objetivos terapéuticos evidencian también interés...
Over the past few years, evidence of a positive relationship between inflammation and depression has grown steadily. The aim current study was to investigate whether such depression-related could also be associated with altered microstructural changes in white matter. FA serum cytokines (IL-1β, IL-6, TNF-α, IFN-γ) were measured 25 patients (DE) 24 healthy controls (HC). Diffusion tensor imaging performed. Fractional anisotropy (FA) calculated using FSL pipeline for Tract-Based Spatial...
Objetivos:Describir la frecuencia de ansiedad, onicofagia y síndrome piernas inquietas (SPI) en estudiantes medicina explorar relación entre los mismos. Materiales métodos: Participaron 315 del primer al quinto año una universidad privada Lima. Se administraron Escala Ansiedad Beck (BAI), escala Likert para onicofagia, el Inventario Estudios Epidemiológicos SPI (García - Borreguero) (Grupo Internacional SPI). Resultados: halló ansiedad (61,3%), (52,63%) (9,29%). Ser hombre es un factor...