A5022584993- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological Disorders and Treatments
- Advanced Glycation End Products research
- Gut microbiota and health
- Stress Responses and Cortisol
- Acute Ischemic Stroke Management
- Tryptophan and brain disorders
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Digestive system and related health
- Kruppel-like factors research
- Ovarian cancer diagnosis and treatment
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Bioactive Compounds
- Complementary and Alternative Medicine Studies
- Neurological Disease Mechanisms and Treatments
- Biochemical effects in animals
- Alcohol Consumption and Health Effects
- Endometriosis Research and Treatment
- Alzheimer's disease research and treatments
- Probiotics and Fermented Foods
- Endometrial and Cervical Cancer Treatments
- Heme Oxygenase-1 and Carbon Monoxide
National Academy of Medical Sciences of Ukraine
2020
Introduction: Diabetes mellitus is associated with the development of carbonyl-oxidative stress (COS) and an increased risk a cerebral hemorrhage. Vitamin D3 considered additional drug to have impact on COS proteolysis in extracellular matrix. Objective: The study aimed evaluate COS-markers matrix metallo-proteinases MMP2/MMP9 activity after acute intracerebral hemorrhage (ICH) rats experimental type 2 diabetes (Т2DM) compared metformin (Met). Methods: T2DM was induced via intraperitoneal...
The aim of this study was to the effect metformin (Met) on formation conditional passive avoidance skills, markers neurogenesis and oxidative stress in brain rats with acute intracerebral hemorrhage (ICH) setting streptozotocin-nicotinamide-induced diabetes. Type 2 diabetes mellitus (T2DM) induced via intraperitoneal injection streptozotocin (STZ) nicotinamide (NA), ICH – by microinjection bacterial collagenase into striatum. Rats were randomly divided four groups: 1 intact animals (n=8),...
Type 2 diabetes mellitus (T2DM) is associated with a higher incidence of hemorrhagic stroke in severe form. The aim this study was to estimate the markers oxidative stress and neuroinflammation brain rats acute intracerebral hemorrhage (ICH) T2DM after treatment edaravone. induced by single intraperitoneal injection nicotinamide/streptozotocin, ICH – stereotactic microinjection bacterial collagenase. Rats were randomized into four groups: 1 intact control; T2DM; 3 T2DM+ICH; 4...
The purpose of the review was to study effects stress on gut microbiota. Results and discussion. microbiota forms a complex microbial community that has significant impact human health. composition varies from person person, it changes throughout life. It is known microbiome can be altered due diet, various processes, such as inflammation and/or stress. Like all other areas medicine, microbiology constantly growing. lives in symbiotic relationship with host. now believed interact almost...
Stroke, especially hemorrhagic form, is one of the most serious comorbidity disease diabetes mellitus, often associated with high mortality, particularly in type 2 DM (T2DM). Therefore, it relevant search for drugs a metabolically justified protective effect. Edaravone (Eda) widely used treating ischemic stroke but its biochemical effects intracerebral hemorrhage (ICH) T2DM not still confirmed. The aim study was to assess impact Eda on markers oxidative modification proteins (OMP), such as...
Clinical evidence suggests that type 2 diabetes mellitus can increase the risk of intracerebral hemorrhage and provocation neurodegeneration. This study was aimed at evaluating biomarkers glycemic control, lipid profile, oxidative modification proteins, as well functional state endothelium in Wistar rats with complicated by hemorrhage. Experimental induced intraperitoneal injection streptozotocin (65 mg/kg) nicotinamide (230 mg/kg). The microinjection sterile saline containing 0.2 IU...
This comparative research is aimed to study the effect of perindopril and metformin on levels biochemical markers endothelial dysfunction in rats with type 2 diabetes mellitus (T2DM) complicated by a brain hemorrhage. The was carried out 30 white male Wistar rats. T2DM simulated single intraperitoneal injection nicotinamide streptozotocin (NA/STZ). Intracerebral hemorrhage (ICH) induced microinjection 1 μL bacterial collagenase 0.2 IU/μL into striatum 60th day experiment. Animals were...
Hyperproduction of highly active carbonyl compounds and reactive oxygen species initiates the development oxidative stress in various pathological conditions protein carbonylation is considered to be one key factors progression diabetes mellitus associated complications. This comparative research aimed study effect metformin rosuvastatin on levels biochemical markers stress, glycemic control, lipid profile rats with type 2 (T2DM) complicated by a brain hemorrhage.T2DM was simulated single...
One of the most relevant and promising areas in world oncogynecology, enabling deeper understanding etiology pathogenesis malignant growth, to study processes occurring women, is molecular biological markers, characterizing apoptosis, cell proliferation angiogenesis. To increase effectiveness combined treatment patients with endometrial cancer I−II (Т1−2N0M0) stages prevent occurrence local recurrences as well distant metastases on basis investigating features tumor their prognostic value, a...
The purpose of the study was to determine morphometric and ultrastructural features neurons glial cells, as well levels fibrillar acid protein in hippocampus rats under long-term administration isoniazid rifampicin during experimental therapy with a combination pro/prebiotics. Materials methods. studies were conducted on three groups white Wistar male drug-induced hepatitis, reproduced by intragastric for 28 days. In last 14 days experiment, research group administered probiotic prebiotic....