A5025820598- Cardiac, Anesthesia and Surgical Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Airway Management and Intubation Techniques
- Anesthesia and Sedative Agents
- Respiratory Support and Mechanisms
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Medical History and Innovations
- Cardiovascular and Diving-Related Complications
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Education and Learning Interventions
- Acute Ischemic Stroke Management
- African Sexualities and LGBTQ+ Issues
- Hemodynamic Monitoring and Therapy
- Intraoperative Neuromonitoring and Anesthetic Effects
- Cardiac Arrest and Resuscitation
- Child Nutrition and Water Access
- Spine and Intervertebral Disc Pathology
- Digital Economy and Work Transformation
- Neurological and metabolic disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- High Altitude and Hypoxia
- Sexual function and dysfunction studies
- Cultural Industries and Urban Development
University of Alberta
2022-2025
University of California, Los Angeles
1996-2023
Stanford University
1977-2023
University of Colorado Boulder
2019-2023
Stollery Children's Hospital
2018-2022
University of Colorado System
2022
New York Academy of Medicine
2021
University of Alberta Hospital
2018
University of British Columbia
2010
Stanford Medicine
1987
We have found that anesthetic technique modifies the neurological and pathological sequelae of unilateral middle cerebral artery internal carotid occlusion in dogs. Occlusion was performed seven groups six dogs during each following regimens: light (0.8%) halothane, "awake," deep (1.9%) halothane with mean arterial pressure reduced to 55 torr, pentobarbital (56 mg per kilogram), plus 40 kilogram thiopental begun just before occlusion, 15 minutes after occlusion. Body temperature, P co 2 o...
The ventilatory response to inhaled carbon dioxide was measured during hyperoxia (Pao2 over 200 torr) and hypoxia of 40 in 14 patients before one nine weeks after carotid endarterectomy for transient attacks cerebral ischemia. Ventilatory unchanged the seven undergoing unilateral endarterectomy. All staged bilateral procedures lost their showed a 5.8-torr increase mean resting Paco2. In four studied, at constant Paco2 increased systolic blood pressure clearly decreased it surgery. Bilateral...
Hyperglycemia has been reported to worsen the tolerance of brain ischemia, and it therefore recommended that patients undergoing neurosurgical procedures not receive glucose-containing solutions. However, whereas most animal studies have used global ischemia models, are associated with risks focal rather than ischemia. We studied effects glucose administration in an model cerebral anesthetized 20 cats halothane (0.85% end tidal oxygen), a ischemic lesion was produced by clip ligation left...
The ventilatory effects of Forane were studied in ten volunteers and compared with values obtained eight anesthetized halothane. Paco2 averaged 60 torr both 1.9 per cent alveolar (approximately 1.45 X MAC) 1.6 halothane (1.9 MAC). slopes the CO2 response curves depressed to 30 ± 6 (Mean SE) awake control by 1.28 1.0 45 7 controls 1.05 (1.25 Therefore, when equivalent anesthetic doses are considered, less than was needed increase depress slope curve. In contrast halothane, increasing...
Anastomotic cerebral perfusion pressures were determined in three patients during carotid endarterectomy under general anesthesia, by measuring distal to the surgically occluded artery (stump pressure) and lateral venous sinus. Hypocarbia increased stump pressure an
Effects of postural changes on anatomic and physiologic dead space arterial-alveolar CO 2 gradients were studied in 11 healthy, adult subjects breathing air O . Results indicate that, moving from the supine to sitting position, Vads Vpds increased by corresponding amounts (42 37 ml) with no increase alveolar or volume lung which is nonperfused. Arterial-alveolar unaffected posture, but more than doubled breathing, suggesting that may relax pulmonary vascular bed diminish perfusion highest...
In clinical medicine, cerebral ischemia is frequently due to a focal, rather than global, insult. The effect of hyperglycemia in focal not well defined. We studied the on neuropathologic changes rabbit model ischemia. Rabbits were randomized receive saline (n = 12) or glucose infusions. left anterior and internal carotid arteries clipped after infusion began. After 6 hours occlusion, area severe ischemic neuronal damage neocortex striatum two standard sections brain was calculated expressed...
LARSON, C. P.; EHRENFELD, W. K.; WADE, J. G.; WYLIE, E. J.; THEYE, RICHARD A. M.D. Author Information
To determine the effectiveness of green banana in home management acute (<7 days) or prolonged (≥ 7 diarrhoea at community level.A cluster randomized field trial was conducted among 2968 Bangladeshi rural children 6-36 months old. Wards (villages) were randomly assigned to either a standard care group plus where mothers instructed add cooked diets diarrhoeal children. Through village-based surveillance system, morbidity data (severity, duration, compliance) collected for 14 days. Treatment...
This study was designed to document the feasibility of self-positioning after awake fiberoptic intubation trachea using primarily effective topical anesthesia rather than sedation.We investigated 14 patients (ASA physical status 1 3) with a neurosurgical diagnosis cervical instability or at risk secondary injury, who were scheduled for and prone. Topical accomplished an oropharyngeal spray lidocaine alone in combination transtracheal injection Patients evidencing anxiolysis given midazolam 2...
This article identifies a mode of intellectual influence and popular celebrity that has emerged alongside American computer science collaborative engineering: “network celebrity.” By tracking the tactics impact three key entrepreneurs — Norbert Wiener, Stewart Brand, Tim O’Reilly traces rise this celebrity. It outlines both new shape network- driven fame dangers inherent in networked modes power.
We compared the performance of a new, continuous intraarterial blood gas (CIABG) monitor with arterial values obtained periodically and analyzed by conventional equipment.A CIABG monitoring system consisting sterile, disposable, fiberoptic sensor microprocessor-controlled self-contained calibration unit detachable display panel was used. The inserted through 20-G radial artery cannula. Light transmitted from to tip where it reacted fluorescent dyes sensitive oxygen or hydrogen ions...
EHRENFELD, W. K.; HAMILTON, F. N.; LARSON, C. P. Jr.; HICKEY, R. F.; SEVERINGHAUS, J. Author Information