A5020086176- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Antimicrobial Peptides and Activities
- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Analysis
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal complexes synthesis and properties
- Immunotherapy and Immune Responses
- RNA and protein synthesis mechanisms
- Polymer Surface Interaction Studies
- Fuel Cells and Related Materials
- Metal-Catalyzed Oxygenation Mechanisms
- Metal-Organic Frameworks: Synthesis and Applications
- Biochemical and Structural Characterization
- Cancer-related gene regulation
- Polydiacetylene-based materials and applications
- Advanced oxidation water treatment
- Dendrimers and Hyperbranched Polymers
- Microbial Natural Products and Biosynthesis
- MicroRNA in disease regulation
George Mason University
2023-2024
National University of Singapore
2022-2024
Indian Institute of Science Education and Research Kolkata
2015-2022
Indian Institute of Technology Kharagpur
2018-2019
Institute of Protein Research
2018
Institute of Mathematical Problems of Biology
2018
University of Calcutta
2018
Keldysh Institute of Applied Mathematics
2018
Constructing artificial ion channels is a challenging task. Herein, the de novo design of transmembrane made up amphiphilic peptide-oligourea chimeric helices described. They consist an oligourea segment (7-mer) attached to C-terminus short peptide (8-mer). Mass spectrometry (MS) and transmission electron microscopy (TEM) analyses show that in aqueous solution, two these chimeras (HPU-E HPU-N) independently form defined oligomeric structures. TEM also shows they fiber bundles. The third...
Cytosolic delivery of functional siRNA remains the major challenge to develop siRNA-based therapeutics. Designing clinically safe and effective transporter deliver across plasma endosomal membrane a key hurdle. With aim improving release, we have designed cyclic linear peptide-based transporters having an Arg-DHis-Arg template. Computational studies show that template is also stabilized by Arg–His side-chain hydrogen bonding interaction at physiological pH, which dissociates lower pH. The...
Designing an effective peptide based molecular transporter for the intracellular delivery of hydrophilic therapeutic biomacromolecules remains a considerable challenge. Highly basic oligoarginine and lipidated arginine rich cell penetrating peptides have been reported in literature as transporters, which were extensively used cellular internalization significantly large biopharmaceuticals. However, transporters with l-arginine residues pose significant challenges due to proteolytic...
Abstract Nature‐inspired self‐assembled peptide‐based nanoscale materials are of great interest for biomedical applications. Here, ionophore gramicidin‐inspired designed drug delivery and cancer nanotherapeutics reported. The length dependent formation diverse nanoarchitectures by experimental computational studies from sequences is explored their therapeutic potential evaluated. Mechanistic revealed that gramicidin A (gA) octapeptide (LD8) induce cytotoxic effects, mitochondrial...
Abstract Designing biologically inspired nanoscale molecular assembly with desired functionality is a challenging endeavour. Here we report the designing of fibrin-inspired nanostructured peptide based sealants which facilitate remarkably fast entrapping blood corpuscles (~28 seconds) in contrast to fibrin (~56 seconds). Our engineered are stabilized by lysine-aspartate ionic interactions and also N ε (γ-glutamyl) lysine isopeptide bond mediated covalent interaction. Each sealant formed two...
Five mononuclear Ru II complexes supported by two pentadentate polypyridyl ligands, N , ‐bis(2‐pyridylmethyl)‐ ‐(bis‐2‐pyridylmethyl)amine (N 4 Py) {[Ru(N Py)(Cl)](PF 6 ), 1 Cl ; [Ru(N Py)(OH 2 )](PF ) Aq } and newly designed ‐benzyl‐ ‐((6‐(6‐methylpyridin‐2‐yl)pyridin‐2‐yl)methyl)dipyridin‐2‐yl‐methanamine Py‐ Me Bpy‐Bz) Bpy‐Bz)(Cl)](PF · MeCN, ·MeCN Bpy‐Bz)(OH 3H O MeOH, ·3H O·MeOH Bpy‐Bz)(MeCN)](PF 0.5MeCN H O, ACN ·0.5MeCN·H were synthesized characterized using different spectroscopic...
The Cover Feature shows an aqua-coordinated mononuclear ruthenium complex with a pentadentate ligand scaffold exhibiting oxidation of water, using cerium(IV) as sacrificial electron acceptor at pH 1. picture also highlights initial side reaction involving oxidative N-debenzylation, which leads to deactivation the catalyst. More information can be found in Full Paper by S. Mandal et al.
In article number 1800018, Dhananjay Bhattacharyya, Rituparna Sinha Roy and co-workers demonstrate the anti-cancer activities of membrane active peptide gramicidin gramicidin-inspired octapeptide LD8 in MDA-MB-231 breast cancer cell line. Doxorubicin loaded doxorubicin induce apoptosis by two different mechanisms.
Plant antimicrobial peptides form an integral component of the innate immunity plants and have activities against a broad spectrum microorganisms.They were classified into various families most share general features such as presence structure-stabilizing disulfide bridges positive charge.Self-aggregation was suggested one possible mechanisms for effect these peptides.Here, we created dataset comprising plant with activity gram negative bacteria.We found that majority antibacterial in this...