The high mortality rate of breast cancer and the difficulties associated with therapeutic resistance, especially in cases where targeted treatments are unavailable, make it a serious threat to women's health. This study examines relationship between three mature microRNAs (miRNAs) that clustered together, namely miR- 23a, 27a, 24-2, as well their potential correlation cancer. We identified common gene targets 24-2 using computational analysis. also checked for levels 26 tumor tissues (with...

Abstract The diagnosis of heterotopic pancreas (HP) is typically made by histopathology rather than a clinical examination which frequently challenging. Gastric outlet obstruction (GOO) one among its many manifestations. Although it extremely uncommon, HP should always be considered possibility when treating with GOO. In this article, we discuss the management and treatment in

Introduction:The American College of Radiology (ACR)-Thyroid Imaging and Reporting Data System (TIRADS) is used to classify the ultrasound (USG) findings Bethesda for Thyroid Cytopathology (TBSRTC) fine needle aspiration (FNAC) a solitary thyroid nodule (STN).Objective: The objective this study assess concordance between TIRADS TBSRTC with final postoperative histopathology in cases STN calculate risk malignancy (ROM). Materials methods:The prospective observational was conducted at tertiary...

Abstract Introduction: Multidisciplinary team (MDT) meeting is a well-established method of optimising care for breast cancer patients. However, its effectiveness has not been proven yet. The present study aims to audit the functioning MDT at tertiary hospital in low-middle income country. Methods: This examines prospectively maintained database patients being discussed meetings occurring from August 2018 till June 2023. was suspended few months between owing COVID pandemic. analysis done...

Abstract Introduction: Inguinal hernia surgery, a common procedure worldwide, continues to develop achieve minimal access and tension-free repairs. However, universally accepted technique has yet be developed. Our study introduces new approach, modified tumescent transabdominal pre-peritoneal (TAPP), low-cost setting. We then compare its safety efficacy with the conventional TAPP, providing perspective on repair methods. Patients Methods: The was conducted between April 2016 September 2017...

Clinical breast examination is a crucial step in the triple assessment of lady presenting with lump, as well for screening. Increased density young females has higher likelihood false negative ndings on sub-optimal clinical and mammography.

Objective: Metaplastic breast carcinoma (MBC) is a heterogeneous group of invasive carcinomas with squamous and/or mesenchymal differentiation. Because their rare occurrence, the information regarding clinical behaviour metaplastic limited. The purpose our study was to delineate clinicopathological and radiological features, treatment outcomes, prognostic factors, survival patients MBC. Methods: Ambispective observational prospective recruitment done from 1st January 2019 31st August 2020....

This is a diagnostic test research study to evaluate the various existing methods of thyroid examination and their comparison with novel modified Rose method. It also aims measure inter-examiner variation in clinical findings based on level education training, as compared ultrasonography.This cross-sectional was conducted at tertiary care hospital 83 patients presenting surgery OPD neck swelling. Each patient examined by one trained Junior Resident Surgery Consultant all four...

Liver is the most common organ involved in hydatid disease. But involvement of multiple organs simultaneously not unheard of. Here we have presented our experience with one such similar case lower lobe right lung and segment VII liver. There was spontaneous rupture cyst during hospital stay. A posterolateral thoracotomy performed for evacuation spilled content from pleural cavity. Intraoperative ultrasound (IOUS) used to locate drain hepatic via diaphragm. Such single incision surgery...

Blunt abdominal trauma can affect mesenteric circulation which may lead to bowel strictures. Indocyanine green (ICG) angiography be used assess blood flow and perfusion as a guide resect length intraoperatively. But this concept has not been applied ischaemic We present case of ileal stricture induced by blunt was managed resection anastomosis. Intraoperative near-infrared (NIR) ICG the length. This emphasises that strictures should suspected in patients presenting with intestinal...

Eccrine porocarcinoma (EPC) is a rare malignant tumour, first reported by Pinkus and Mehregan in 1963. It can develop from the eccrine duct epithelial component or transform an underlying poroma. The tumor usually presents as exophytic growth has female predilection. Rarely it occur scalp, face, ear, genitalia eye lids. Treatment modalities have included standard excision, Mohs micrographic surgery, chemotherapy, radiation therapy. Therapy of choice surgical excision with clear margins...

Aim and objective: To determine the sensitivity, specificity, positive predictive value (PPV), negative (NPV) of ultrasound cytology to detect malignancy for solitary thyroid nodules.Materials methods: Prospective observational study conducted at a tertiary care hospital in India.The patients with nodule, aged more than 12 years consent patients/their parents planned undergo surgery, were included study.The evaluated history, examination, sonography, cytology.Then, they surgical hemi-/total...

Abstract Background Grading the illness using clinical parameters is essential for daily progress of inpatients. Existing systems do not incorporate these holistically. The study was designed to internally validate wellness scale, based upon assessment patients requiring surgical care, their risk stratification and uniformity communication between health care providers. Methods Prospective observational conducted at a tertiary hospital. An expert panel devised it modified after feedback from...

A 25 year old female had presented with complaints of severe epigastric pain abdominal distension and vomiting for 4 days. She undergone medical termination pregnancy a missed abortion 5 weeks gestation days prior. The patient's COVID-19 RT PCR was found to be positive. Her CECT showed covid related changes in bilateral lungs pneumoperitoneum. Stomach distended. Other small bowels appeared normal. Patient underwent emergency laparotomy. Two third stomach gangrenous perforation the posterior...