A5019210491- Hedgehog Signaling Pathway Studies
- CAR-T cell therapy research
- Fibroblast Growth Factor Research
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Proteoglycans and glycosaminoglycans research
- Developmental Biology and Gene Regulation
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Acute Lymphoblastic Leukemia research
- Wnt/β-catenin signaling in development and cancer
- Genetics and Neurodevelopmental Disorders
- Oral and gingival health research
- Hippo pathway signaling and YAP/TAZ
- Renal Transplantation Outcomes and Treatments
- Ocular Disorders and Treatments
- Genomic variations and chromosomal abnormalities
- Chronic Myeloid Leukemia Treatments
- Cell death mechanisms and regulation
University of Münster
2014-2023
University Medical Center Freiburg
2003
University of Freiburg
1999-2001
ABSTRACT All morphogens of the Hedgehog (Hh) family are synthesized as dual-lipidated proteins, which results in their firm attachment to surface cell they were produced. Thus, Hh release into extracellular space requires accessory protein activities. We suggested previously that proteolytic removal N- and C-terminal lipidated peptides (shedding) could be one such activity. More recently, secreted glycoprotein Scube2 (signal peptide, cubulin domain, epidermal-growth-factor-like 2) was also...
Abstract Decision making in cellular ensembles requires the dynamic release of signaling molecules from producing cells into extracellular compartment. One important example that require regulated order to signal over several cell diameters is Hedgehog (Hh) family, because all Hhs are synthesized as dual-lipidated proteins firmly tether outer membrane leaflet produces them. Factors for vertebrate Hh family member Sonic (Shh) include cell-surface sheddases remove lipidated terminal peptides,...
Proteolytic processing of cell-surface-bound ligands, called shedding, is a fundamental system to control cell-cell signaling. Yet, our understanding how shedding regulated still incomplete. One way increase the dual-lipidated membrane-associated Sonic hedgehog (Shh) density substrate and sheddase. This releases also activates Shh by removal lipidated inhibitory N-terminal peptides from receptor binding sites. release activation enhanced Scube2 [signal sequence, cubulin (CUB) domain,...
Morphogens determine cellular differentiation in many developing tissues a concentration dependent manner. As central model for gradient formation during animal development, Hedgehog (Hh) morphogens spread away from their source to direct growth and pattern the Drosophila wing disc. Although heparan sulfate (HS) expression disc is essential this process, it not known whether HS regulates Hh signaling or an indirect To answer question, we systematically screened two composite binding areas...
Human lymphocytes remain among the most promising target cells for gene therapy. Gene-modified have been used successfully to treat adenosine deaminase (ADA)-deficient patients and control GvHD after allogeneic BMT. Because activation proliferation of T are necessary efficient retrovirus-mediated transfer subsequent selection transduced cells, mononuclear (MNC) from steady-state G-CSF-stimulated peripheral blood were activated by short exposure mitogen PHA, anti-CD3 antibody OKT3, or both in...
Abstract: The Fas ligand (FasL) pathway is one of the two major effector mechanisms T‐cell‐mediated cell death. FasL expression by extralymphatic tissues thought to maintain a status immunity. Accordingly, it has been proposed that tumor cells express as mechanism immunologic escape. However, data regarding in normal or neoplastic remain controversial. In present study, we investigated peripheral blood B lymphocytes malignant B‐lymphocyte lineage elucidate possible counterattack mechanism....