A5058004603- Pluripotent Stem Cells Research
- Molecular Biology Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- CRISPR and Genetic Engineering
- 3D Printing in Biomedical Research
- Pharmacogenetics and Drug Metabolism
- Pneumonia and Respiratory Infections
- Healthcare cost, quality, practices
- Gene expression and cancer classification
- Eosinophilic Esophagitis
- Biomedical and Chemical Research
- Adrenal Hormones and Disorders
- Osteoarthritis Treatment and Mechanisms
- Healthcare Policy and Management
- Burn Injury Management and Outcomes
- Pain Mechanisms and Treatments
- Mechanical Circulatory Support Devices
- Mesenchymal stem cell research
- Nuclear Receptors and Signaling
- Sympathectomy and Hyperhidrosis Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Ethics in Clinical Research
- Drug-Induced Hepatotoxicity and Protection
University of Konstanz
2023
Tongji University
2023
University of Cologne
2023
TU Dortmund University
2018-2023
Leibniz Research Centre for Working Environment and Human Factors
2018-2023
Klinik und Poliklinik für Kinder- und Jugendmedizin
2023
Technische Universität Dresden
2023
Charité - Universitätsmedizin Berlin
2021
Heinrich Heine University Düsseldorf
1998-2005
Kernkraftwerk Gundremmingen
1990
Despite the introduction of effective medical treatment peptic ulcer disease, bleeding is still a frequent complication. The aim this study was to investigate whether incidence and risk profile haemorrhage have changed within 10-year period.In prospective epidemiological observational in Düsseldorf, Germany were compared between two time periods (period A: 1.3.89-28.2.90 period B: 1.4.99-31.3.2000), involving nine hospitals with both surgical departments. Patients proven at endoscopy or...
The purpose of the present study was to investigate effect intra-articular injections autologous conditioned serum on human hip osteoarthritis and test whether a potential treatment might be increased by additional steroids recombinant interleukin-1 receptor antagonist protein anakinra. We compared effects 46 patients), serum+cortisone (56 serum+cortisone+recombinant (17 patients) in retrospective clinical means Visual Analogue Scale for pain (pre- vs posttreatment). Over 14 months, resulted...
Despite the progress made in developmental toxicology, there is a great need for vitro tests that identify toxicants relation to human oral doses and blood concentrations. In present study, we established hiPSC-based UKK2 test analyzed genome-wide expression profiles of 23 known teratogens 16 non-teratogens. Compounds were at maximal plasma concentration (
Human-relevant tests to predict developmental toxicity are urgently needed. A currently intensively studied approach makes use of differentiating human stem cells measure chemically-induced deviations the normal program, as in a recent study based on cardiac differentiation (UKK2). Here, we (i) tested performance an assay modeling neuroepithelial (UKN1), and (ii) explored benefit combining assays (UKN1 UKK2) that model different germ layers. Substance-induced cytotoxicity genome-wide...
Abstract BackgroundThe Federal Ministry of Research and Education funded the Network University Medicine for establishing an infrastructure pandemic research. This includes development a COVID-19 Data Exchange Platform (CODEX) that provides standardised harmonised data sets Nearly all university hospitals in Germany are part project transmit medical from local integration centres to CODEX platform. The on person has been collected at several sites is be made available platform merged form....
Animal studies for embryotoxicity evaluation of potential therapeutics and environmental factors are complex, costly, time-consuming. Often, not human relevance because species differences. In the present study, we recapitulated process cardiomyogenesis in induced pluripotent stem cells (hiPSCs) by modulation Wnt signaling pathway to identify a key gene signature that can be applied compounds and/or stress compromising process. Among 23 tested teratogens 16 non-teratogens, identified three...
Abstract Animal studies for embryotoxicity evaluation of potential therapeutics and environmental factors are complex, costly, time-consuming. Often, not human relevance because species differences. In the present study, we recapitulated process cardiomyogenesis in induced pluripotent stem cells (hiPSCs) by modulation Wnt signaling pathway to identify a key gene signature that can be applied compounds and/or stress compromising process. Among 23 tested teratogens 16 non-teratogens,...
Zur Überprüfung des Einflusses der piezoelektrischen Stoßwellengeneration auf das Reizleitungssystem Herzens wurde bei 50 konsekutiven Patienten während EPL-Behandlung eine permanente EKG-Ableitung aufgezeichnet. In einem experimentellen Versuchsaufbau zudem ein Demandschrittmacher Stoßwellenapplikation bzw. den hierbei entstehenden Feldstärkenänderungen ausgesetzt.