A5050167699- Epigenetics and DNA Methylation
- RNA Research and Splicing
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Immune Cell Function and Interaction
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Cancer-related molecular mechanisms research
- Telomeres, Telomerase, and Senescence
Institute of Genomics and Integrative Biology
2024
Council of Scientific and Industrial Research
2024
Academy of Scientific and Innovative Research
2024
Institute for Stem Cell Biology and Regenerative Medicine
2018-2019
Euchromatic histone methyltransferases (EHMTs), members of the KMT1 family, methylate and non-histone proteins. Here, we uncover a novel role for EHMTs in regulating heterochromatin anchorage to nuclear periphery (NP) via methylation. We show that stabilize LaminB1 (LMNB1), which associates with H3K9me2-marked peripheral heterochromatin. Loss LMNB1 methylation or abrogates at NP further demonstrate loss induces many hallmarks aging including global reduction H3K27methyl marks altered...
Abstract Euchromatic histone methyltransferases (EHMT1/2) play a key role in adipogenesis by regulating gene expression. While the downstream functions of EHMTs adipogenic differentiation have been studied, their regulation and precise individual contributions remain elusive. We discovered existence regulatory mechanism, wherein EHMT1 governs interdependent expression itself master regulator PPARƴ during early phase adipogenesis. In later stages, EHMT2 levels decline along with reduction...
Cultured human embryonic stem cells (hESCs) can develop genetic anomalies that increase their susceptibility to transformation. In this study, we characterized a variant hESC (vhESC) line and investigated the molecular mechanisms leading drift towards transformed state. Our findings revealed vhESCs up-regulate EMT-specific markers, accelerate wound healing, exhibit compromised lineage differentiation, retain pluripotency gene expression in teratomas. Furthermore, discovered an altered...
Abstract Euchromatic histone methyltransferases (EHMTs), members of the KMT1 family, methylate and non-histone proteins. Here we uncover a novel role for EHMTs in regulating heterochromatin anchorage to nuclear periphery (NP) via (LaminB1) methylations. We show that methylates stabilizes LaminB1 (LMNB1), which associates with H3K9me2-marked peripheral heterochromatin. Loss LMNB1 methylation or abrogates from NP. further demonstrate loss induces many hallmarks aging including global reduction...