A5003136976- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Sleep and Wakefulness Research
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Neuroscience and Neural Engineering
- Circadian rhythm and melatonin
- Genetic Neurodegenerative Diseases
- Memory and Neural Mechanisms
University of Michigan
2019-2020
Motor thalamus (Mthal) comprises the ventral anterior, lateral, and medial thalamic nuclei in rodents. This subcortical hub receives input from basal ganglia (BG), cerebellum, reticular addition to connecting reciprocally with motor cortical regions. Despite central location of Mthal, mechanisms by which it influences movement remain unclear. To determine its role generating ballistic, goal-directed movement, we recorded single-unit Mthal activity as male rats performed a two-alternative...
Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or an underlying rhythm is unknown. Here, we show a previously undescribed respiratory-driven oscillation the human hippocampus that couples with cardinal oscillations. Further, breathing promotes nesting of ripples slow together suggesting respiration acts as intrinsic to coordinate synchronization providing unique framework...
The neurophysiological mechanisms supporting brain maturation are fundamental to attention and memory capacity across the lifespan. Human regions develop at different rates, with many developing into third fourth decades of life. Here, in this preregistered study (https://osf.io/gsru7), we analyzed intracranial EEG (iEEG) recordings from widespread a large developmental cohort. Using task-based (i.e., to-be-remembered visual stimuli) task-free (resting-state) data 101 children adults (5.93 -...
Field potential (FP) oscillations are believed to coordinate brain activity over large spatiotemporal scales, with specific features (e.g., phase and power) in discrete frequency bands correlated motor output. Furthermore, complex correlations between distinct (phase-amplitude, amplitude-amplitude, phase-phase coupling) commonly observed. However, the mechanisms underlying FP-behavior cross-frequency coupling remain unknown. The thalamus plays a central role generating many circuit-level...
Abstract The thalamus plays a central role in generating circuit-level neural oscillations believed to coordinate brain activity over large spatiotemporal scales. Such thalamic influences are well-documented for sleep rhythms and sensory systems, but the relationship between activity, motor circuit local field potential (LFP) oscillations, behavior is unknown. We recorded wideband (Mthal) electrophysiology as healthy rats performed two-alternative forced choice task. power of delta (1 − 4...