A5058091324- Influenza Virus Research Studies
- Immune Cell Function and Interaction
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
University of Chicago
2017-2019
Center for Rheumatology
2018
A distinct population of B cells that respond to vaccination serve as potential plasma cell precursors.
Vaccines are among the most effective public health tools for combating certain infectious diseases such as influenza. The role of humoral immune system in vaccine-induced protection is widely appreciated; however, our understanding how antibody specificities relate to B cell function remains limited due complexity polyclonal responses. To address this, we developed Spec-seq framework, which allows simultaneous monoclonal (mAb) characterization and transcriptional profiling from same single...