Vascular endothelial growth factor (VEGF) plays a crucial role in angiogenesis and pathological processes such as tumor growth, rheumatoid arthritis, ocular neovascularization. A recombinant humanized monoclonal antibody (rhuMAb), rhuMAb VEGF, has been developed to inhibit the effects of VEGF treatment solid tumors. Intravenous s.c. pharmacokinetic studies were conducted mice, rats, cynomolgus monkeys. In addition, tissue distribution i.v. 125I-rhuMAb was investigated rabbits. At dose...

A higher sodium gradient (dialysate minus pre-dialysis plasma sodium) during hemodialysis (HD) has been associated with loading; however, its role is not well studied. We hypothesized that a dialysate prescription resulting in increases interdialytic weight gain (IDWG), blood pressure (BP) and thirst.We conducted cross-sectional study on 1084 clinically stable patients HD. descriptive analysis of the was performed clinical associations were analyzed.The varied widely across dialysis...

Accurate measurement of intraoperative blood loss is an important clinical variable in managing fluid resuscitation and avoiding unnecessary transfusion products. In this study, lost onto laparotomy sponges during surgical cases was measured using a tablet computer programmed with unique algorithm modeled after facial recognition technology. we assessed the accuracy performance system cases.In prospective, multicenter 46 patients undergoing surgery anticipated significant contributed for...

Incident reporting systems (IRSs) are important patient safety tools for identifying risks and opportunities improvement. A major IRS limitation is underreporting of incidents. Perioperative anesthesia IRSs have been established at multiple pediatric institutions a national perioperative serious adverse events (SAEs) maintained by Wake Up Safe (WUS), organization dedicated to quality confidential, electronic, was instituted our tertiary children's hospital, which WUS member. The primary...

In Brief BACKGROUND: Accurate measurement of intraoperative blood loss is an important clinical variable in managing fluid resuscitation and avoiding unnecessary transfusion products. this study, we measured surgical using a tablet computer programmed with unique algorithm modeled after facial recognition technology. The aim the study was to assess accuracy performance system on laparotomy sponges vitro. METHODS: Whole samples premeasured hemoglobin (Hb) volume were reconstituted from units...

Prolonged fetal tracheal occlusion (TO) accelerates lung growth but leads to loss of alveolar epithelial type II (AE2) cells. In contrast, temporary TO recovery AE2 cells and their ability produce surfactant. The aim this study was determine the effects in sheep with hypoplasia on postnatal function, structure, surfactant protein mRNA expression. Diaphragmatic hernia (DH) created 22 at 65 days gestation. performed between 110 gestation full term (DH/TO, n = 7) 130 (DH/TO+R, 6). Sham-operated...

Prothrombin complex concentrates are an emerging "off-label" therapy to augment hemostasis after cardiopulmonary bypass (CPB), but data supporting their use for neonatal cardiac surgery limited.We retrospectively reviewed neonates undergoing open heart with first-time sternotomy between May 2014 and December 2018 from a hospital electronic health record database. Neonates who received activated 4-factor prothrombin concentrate (a4FPCC) CPB were propensity score matched (PSM) did not receive...

Summary Background Combined heart and liver transplantation ( CHLT ) in the pediatric population involves a complex group of patients, many whom have palliated congenital disease CHD involving single ventricle physiology. Objective The purpose this study was to describe perioperative management patients undergoing at institution identify strategies that may be used optimize care. Methods We did retrospective database review all receiving children's hospital between 2006 2014. Information...

Technical variant liver transplantation (TVLT) is a strategy to mitigate persistent pediatric waitlist mortality in the United States, although its implementation remains stagnant. This study investigated relationship between TVLT utilization, transplant center volume, and graft survival.

Background: The goal of preoperative fasting is to prevent pulmonary aspiration during general anesthesia. Fasting times are often prolonged leading patient discomfort and risk for adverse events. This retrospective quality improvement survey evaluated effective nil-per-os (NPO) causes NPO with the aim suggest strategies by a newly founded task force.Methods: Data from all electronic anesthesia records 2019 at our institution were reviewed times. Our instructions follow American Society...

Objective . This study aims to highlight the challenges in diagnosis of hyperparathyroidism (HPT) patients with advanced chronic kidney disease (CKD). Methods In this report, we describe a middle-aged Filipino gentleman underlying CKD who presented intractable nausea, vomiting, severe and medically refractory hypercalcaemia parathyroid hormone (PTH) concentrations excess 2400 pg/mL. The pathophysiology as well aetiologies current relevant literature are discussed. We also suggest an...

The reported incidence of transplant renal artery stenosis (TRAS), as high 23% in earlier decades [1], ranges between 1.2 and 3.9% more recent reports [2–5]. TRAS is a frequent cause refractory hypertension allograft dysfunction [5], but it often treatable with percutaneous angioplasty. Therefore, its early recognition critical. We describe the our center over 10-year period report case to illustrate complexity diagnosis patients slowly recovering graft function, multiple arteries...

Abstract We examined the effect of accelerated lung growth, induced by in utero tracheal occlusion (TO), on liquid uptake near‐term fetal sheep. In TO was performed five sheep at 110 days gestation (term, ∼145 days); six SHAM operated fetuses served as controls. The rate movement across pulmonary epithelium measured, using a previously established technique, anesthetized between 133–137 during 2‐hr adrenaline infusion (0.50 μg/min/kg, I.V.) and while luminal pressure maintained 5 mmHg....

Abstract Introduction Transfusion protocols are not well‐studied for pediatric patients with acute liver failure (ALF). This study evaluates the utility of an international normalized ratio (INR)‐based transfusion threshold these patients. Methods Forty‐four ALF from 2009 to 2018 were reviewed and divided into two groups: (a) a group including between 2015 who transfused INR above 3.0, per institutional policy (n = 30), (b) post‐threshold after through based on clinical judgment 14)....

A 34 year-old Hispanic female with a history of nephrolithiasis presented right flank pain and fever. non-contrast computer tomography (CT) showed 4.1 × 3.9 cm cystic lesion in the kidney lower pole 6 mm non-obstructive renal calculus. She was treated cephalexin for Escherichia coli (E. coli) urinary tract infection. One year later she returned to emergency room recurrent pain, fever, positive punch bulge on her (Figure 1 white arrow). new contrast CT abdomen several fluid collections...

Background: Liver failure is characterized by abnormal bleeding and clotting as the liver produces majority of procoagulant, fibrinolytic, regulatory proteins coagulation system. transplantation (LT) carries high risk intraoperative bleeding. Thromboelastography (TEG), a global assay, measures several aspects clot formation in real time used to guide blood product administration including LT. However, no data on description TEG parameters during pediatric LT exist. Methods: An IRB-approved...