A5103166591- Colorectal Cancer Surgical Treatments
- Advanced Radiotherapy Techniques
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Pancreatic function and diabetes
- Colorectal and Anal Carcinomas
- Advances in Oncology and Radiotherapy
- MicroRNA in disease regulation
- Colorectal Cancer Screening and Detection
- Cannabis and Cannabinoid Research
- Clinical practice guidelines implementation
- Medical Image Segmentation Techniques
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Diabetes and associated disorders
- Cancer, Hypoxia, and Metabolism
- Hematopoietic Stem Cell Transplantation
- Economic and Financial Impacts of Cancer
- RNA and protein synthesis mechanisms
- MRI in cancer diagnosis
- Effects of Radiation Exposure
- Estrogen and related hormone effects
- Mesenchymal stem cell research
- Cancer, Stress, Anesthesia, and Immune Response
AZ Sint-Jan
2016-2024
Center for Beta Cell Therapy in Diabetes
2018-2021
Vrije Universiteit Brussel
2016-2017
Foundation Medicine (United States)
2016
Universitair Ziekenhuis Leuven
2007-2011
KU Leuven
2007-2010
University of California, Los Angeles
1989
To investigate the use of FDG-PET/CT before, during and after chemoradiotherapy (CRT) diffusion-weighted magnetic resonance imaging (DW-MRI) before CRT for prediction pathological response (pCR) in rectal cancer patients.Twenty-two patients treated with long course were included. An was performed prior to start CRT, 10 12 fractions five weeks end CRT. The tumor delineated using a gradient based delineation method maximal standardized uptake values (SUV(max)) calculated. A DW-MRI Mean...
Purpose. The purpose of this study is to investigate the use PET/CT with fluorodeoxyglucose (FDG), fluorothymidine (FLT) and fluoromisonidazole (FMISO) for radiotherapy (RT) target definition evolution in rectal cancer. Materials methods. was performed before during preoperative chemoradiotherapy (CRT) 15 patients resectable PET signals were delineated CT images on different time points non-rigidly registered. Mismatch analyses carried out quantify overlap between FDG FLT or FMISO tumour...
Objective Previous studies demonstrated that circulating microRNA-375 (miR-375) is a suitable plasma biomarker for real-time detection of beta cell death. The present study evaluated the use this to assess cytoprotective effect phenylpropenoic acid glucoside (PPAG), which was previously protect cells against various types injury, and exendin-4, an established antidiabetic drug. Methods PPAG or exendin-4 were administered in mice treated with streptozotocin (STZ) acutely induce Beta mass...
Abstract Partial pancreatic duct ligation (PDL) of mouse pancreas induces a doubling the β -cell mass mainly through proliferation pre-existing and newly formed -cells. The molecular mechanism governing this process is still largely unknown. Given inflammatory nature PDL inflammation-induced signaling via signal transducer activator transcription 3 (STAT3), activation role STAT3 in PDL-induced were investigated. Duct stimulates expression several cytokines that can act as ligands inducing...
A disproportional increase of circulating GAD65 within hours from an intraportal islet allotransplantation has been validated as biomarker beta cell loss and poor functional outcome. More sensitive assays are, however, needed to allow detection episodes subtle during late-stage graft rejection or in the peri-onset period type 1 diabetes. We applied same sandwich monoclonal antibody couple reactive towards C- N-terminus on three advanced immunoassay platforms—the Cytometric Bead Array (CBA,...
Several biomarkers have been proposed to detect pancreatic β cell destruction in vivo but so far not compared for sensitivity and significance.We used islet transplantation as a model compare plasma concentrations of miR-375, 65-kDa subunit glutamate decarboxylase (GAD65), unmethylated insulin DNA, measured at subpicomolar sensitivity, study their discharge kinetics, power outcome prediction, detection graft loss during follow-up.At 60 minutes after transplantation, GAD65 miR-375...
Abstract Purpose : Quantification of set-up errors is necessary to assess the accuracy patient positioning and define margins. In this article, we describe analysis two different verification correction procedures in pelvic irradiation for rectal cancer patients treated on a belly-board device. Methods First, conducted retrospective study ten patients. Skin marks were used position was verified corrected at start treatment by portal imaging. Second, analysed implementation more rigorous...
Ongoing beta cell death in type 1 diabetes (T1D) can be detected using biomarkers selectively discharged by dying cells into plasma. microRNA-375 (miR-375) ranks among the top based on studies animal models and human islet transplantation. Our objective was to identify additional microRNAs that are co-released with miR-375 proportionate amount of destruction. RT-PCR profiling 733 a discovery cohort T1D patients h before/after transplantation indicated increased plasma levels 22 microRNAs....
Abstract: Radiation therapy (RT) is an essential treatment modality for cancer care and cure. Over the years, radiation treatments have become more complex computerized leading to highly precise approaches maximising loco-regional control while minimizing toxicity. Safe effective radiotherapy delivery however requires implementation of adapted quality assurance (QA) programs integral management (QM) systems, favouring continuous improvement. These improvements can arise within local or...