A5039421245- Sleep and Wakefulness Research
- Pain Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Genetic Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Pain Management and Placebo Effect
- Neuropeptides and Animal Physiology
- Psychedelics and Drug Studies
- Neurological disorders and treatments
- Circadian rhythm and melatonin
- Neurobiology and Insect Physiology Research
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
McGill University
2021-2025
Research Network (United States)
2023
Northwestern University
2023
Aligning Science Across Parkinson's
2023
McGill University Health Centre
2022
Significance Social behavior (SB) is a fundamental hallmark of human interaction. Repeated administration low doses the 5-HT 2A agonist lysergic acid diethylamide (LSD) in mice enhances SB by potentiating and AMPA receptor neurotransmission mPFC via an increasing phosphorylation mTORC1, protein involved modulation SB. Moreover, inactivation glutamate impairs nullifies prosocial effects LSD. Finally, LSD requires integrity mTORC1 excitatory glutamatergic, but not inhibitory neurons, to...
Abstract Dopamine neurons are characterized by their response to unexpected rewards, but they also fire during movement and aversive stimuli. neuron diversity has been observed based on molecular expression profiles; however, whether different functions map onto such genetic subtypes remains unclear. In this study, we established that three dopamine within the substantia nigra pars compacta, of Slc17a6 ( Vglut2 ), Calb1 Anxa1 , each have a unique set responses stimuli accelerations...
Sleep disorders affect millions of people around the world and have a high comorbidity with psychiatric disorders. While current hypnotics mostly increase non-rapid eye movement sleep (NREMS), drugs acting selectively on enhancing rapid (REMS) are lacking. This polysomnographic study in male rats showed that first-in-class selective melatonin MT 1 receptor partial agonist UCM871 increases duration REMS without affecting NREMS. The REMS-promoting effects occurred by inhibiting, dose–response...
Abstract Background Neuropathic pain (NP) is a chronic and debilitating condition frequently comorbid with insomnia. However, the alterations in sleep architecture under NP conditions mechanisms underlying both disturbances remain poorly understood. The reticular thalamic nucleus (RTN) plays crucial role non-rapid eye movement (NREMS) processing, but its involvement NP-related disruptions has not been fully elucidated. Methods To investigate sleep-related electrophysiological changes NP, we...
Melatonin, through its G protein-coupled receptor (GPCR) (MTNR1B gene) MT2 , is implicated in analgesia, but the relationship between receptors and opioid system remains elusive. In a model of rodent neuropathic pain (spared nerve injured [SNI]), selective melatonin agonist UCM924 reversed allodynia (a response to non-noxious stimulus), this effect was nullified by pharmacological blockade or genetic inactivation mu (MOR), not delta (DOR). Indeed, SNI MOR, DOR knockout mice, did respond...
This protocol describes the three surgical procedures required for simultaneous optogenetic stimulation in Substantia Nigra pars compacta (SNc) and acute fiber photometry dorsal striatum: 1. Viral injection of a red-shifted channelrhodopsin, ChRmine, SNc, green dopamine sensor, GRAB-DA3m, striatum. 2. Fiber-optic cannula implantation into SNc stimulation. 3. Craniotomy above striatum photometry.