A5086007935- interferon and immune responses
- Inflammasome and immune disorders
- Viral Infections and Vectors
- Adenosine and Purinergic Signaling
- Phase Change Materials Research
- Signaling Pathways in Disease
- Autism Spectrum Disorder Research
- Biofuel production and bioconversion
- Clostridium difficile and Clostridium perfringens research
- Bacterial biofilms and quorum sensing
- Advanced Nanomaterials in Catalysis
- Thermal Analysis in Power Transmission
- Electrohydrodynamics and Fluid Dynamics
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Surface Modification and Superhydrophobicity
- Non-Destructive Testing Techniques
- Cassava research and cyanide
- Fluorine in Organic Chemistry
- Microbial Metabolites in Food Biotechnology
- HIV Research and Treatment
- Nanoplatforms for cancer theranostics
- Applied Advanced Technologies
- Enzyme Catalysis and Immobilization
- Bacteriophages and microbial interactions
Xinyang Normal University
2025
Chinese Academy of Sciences
2016-2024
Shanghai Institute of Materia Medica
2022-2024
Nanjing University of Chinese Medicine
2022-2024
CHN Energy (China)
2022-2024
Shenhua Group (China)
2024
Jilin University of Chemical Technology
2022
Fujian Institute of Research on the Structure of Matter
2016-2017
Fujian Agriculture and Forestry University
2017
Fuzhou University
2017
Abstract Ginkgo biloba extract is reported to have therapeutic effects on aging‐related disorders. However, the specific component responsible for this biological function and its mechanism of action remain largely unknown. This study finds that Ginkgetin, an active ingredient extract, can alleviate cellular senescence improve pathologies in multiple tissues aging mice. To reveal molecular Ginkgetin's anti‐aging effect, a graph convolutional network‐based drug “on‐target” pathway prediction...
The development of stimulator interferon genes (STING) agonists has been potential applications for the treatment cancer and infectious diseases. Based on crystal structure SR-717 bound to hSTING, we designed synthesized a novel series bipyridazine derivatives as highly potent STING agonists. Among them, compound 12L led significant thermal stability shifts common alleles well that mSTING. also displayed activities in various hSTING mSTING competition binding assay. Specifically, higher...
A multifunctional nanoplatform, MSN@C-dots/RB, is fabricated for drug delivery and imaging-guided chemo/photodynamic synergistic therapy.
This work demonstrates a simple, mild and efficient alkenyltrifluoromethylation of alkynes with readily available 2‐arylaminonaphthalene‐1,4‐diones Togni reagent as coupling partners. With both photosensitizers substrates, the title reaction proceeds smoothly in ethyl acetate under irradiation blue light, affording series CF3‐functionalized alkenes excellent regio‐ stereoselectivity. protocol features good tolerance functional groups, conditions, green solvent no involvement external...
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The aim of this study was to assess the effects a partially parent-implemented self-management intervention incorporating video-modelling for discrimination training on improving social skills in child with autism spectrum disorder (ASD). participant 9-year-old girl ASD. A multiple baseline across behaviour design (no interruption, asking opinions, and appropriately greeting unfamiliar adults) used intervention. Results showed: (a) associated improvements all target behaviours setting strong...
Cellulases are produced by microorganisms that grow on cellulose biomass. Here, a cellulase, Cel10, was identified in strain of Klebsiella pneumoniae isolated from Chinese bamboo rat gut. Analysis substrate specificity showed Cel10 is able to hydrolyze amorphous carboxymethyl (CMC) and crystalline forms (Avicel xylan) but unable p -nitrophenol β-D-glucopyranoside ( -NPG), proving an endoglucanase. A phylogenetic tree analysis indicates belongs the glycoside hydrolase 8 (GH8) subfamily. In...
Helicobacter pylori , a Gram-negative bacterial pathogen prevalent in the human population, is causative agent of severe gastric diseases. An H. type IV secretion (T4S) system encoded by cytotoxin-associated gene pathogenicity island ( cag PAI) responsible for communication with host cells. As component PAI T4S core complex, CagX plays an important role virulence-protein translocation into In this work, crystal structure C-terminal domain (CagXct), which homologue VirB9 protein from VirB/D4...
Plate heat exchangers are realized by means of a transfer mechanism, in which is naturally transferred from the hot substance to object with lower temperature according laws thermodynamics. Two liquids different temperatures flow on wall, wall and convection liquid thus promoting between two liquids. Under same rate power consumption conditions, its coefficient three times that shell tube exchangers, key efficient new equipment for effectively using effective resources saving developing...
Hydraulic oil leaks during mechanical maintenance, resulting in flushing wastewater contaminated with dispersed nano-oil droplets. In this study, 75 mg L
In order to offset the lag and delay in heating process solve problem of excessive season, an energy-saving control method district system based on MATLAB is proposed. Based MATLAB/SIMULINK software, simulation model established study its dynamic characteristics. The short-term load forecasting introduced guide conduct centralized regulation observe response indoor temperature operating energy consumption. Compared with constant water supply outdoor compensation method, results show that...