A5040619077- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Muscle Physiology and Disorders
- Neuroendocrine regulation and behavior
- Hernia repair and management
- Exercise and Physiological Responses
- Heat shock proteins research
- Neuroscience of respiration and sleep
- MicroRNA in disease regulation
- Abdominal Surgery and Complications
- Pituitary Gland Disorders and Treatments
- Innovation Diffusion and Forecasting
- 3D Printing in Biomedical Research
- Circadian rhythm and melatonin
- Graphene and Nanomaterials Applications
- Cancer-related molecular mechanisms research
- Capital Investment and Risk Analysis
- thermodynamics and calorimetric analyses
- Urological Disorders and Treatments
- Spaceflight effects on biology
- Innovation and Knowledge Management
- Anorectal Disease Treatments and Outcomes
- Cancer, Hypoxia, and Metabolism
- Diet and metabolism studies
- Muscle metabolism and nutrition
University of Messina
2024
Agostino Gemelli University Polyclinic
2020
National Agency for New Technologies, Energy and Sustainable Economic Development
2011-2019
Sapienza University of Rome
2011-2019
McGowan Institute for Regenerative Medicine
2014-2017
IRCCS Humanitas Research Hospital
2016
University of Palermo
2016
University of Debrecen
2016
University of KwaZulu-Natal
2016
San Raffaele University of Rome
2014-2016
Skeletal muscle atrophy occurs during disuse and aging, or as a consequence of chronic diseases such cancer diabetes. It is characterized by progressive loss tissue due to hypotrophic changes, degeneration, an inability the regeneration machinery replace damaged myofibers. Tumor necrosis factor (TNF) proinflammatory cytokine known mediate in many inhibit skeletal regeneration. In this study, we investigated role Arg-vasopressin-(AVP-)dependent pathways muscles which was induced local...
The multipotency of scaffolds is a new concept. Skeletal muscle acellular (MAS) implanted at the interface Tibialis Anterior/tibial bone and masseter muscle/mandible in murine model were colonized by cells near host bone-cartilaginous tissues bone, thus highlighting importance environment directing cell homing differentiation. These results unveil MAS point to potential this technique as valuable tool musculo-skeletal tissue regeneration.
The extracellular matrix (ECM) of decellularized organs possesses the characteristics ideal tissue-engineering scaffold (i.e. histocompatibility, porosity, degradability, non-toxicity). We previously observed that muscle acellular (MAS) is a pro-myogenic environment in vivo. In order to determine whether MAS, which basically ECM, behaves as myogenic environment, regardless its location, we analysed MAS interaction with both and nonmuscle cells tissues, assess effects on cell differentiation....
Exposure to microgravity induces skeletal muscle disorders including atrophy, force decrease, fibre-type shift. Microgravity also contributes immune-function alterations and modifies microRNAs (miRs) expression. To understand the link between microgravity-induced atrophy immune function deregulation, a bioinformatics study was performed. The web platform MiRNet used for miRs-targets interaction analysis from previous proteomic studies on human soleus (SOL) vastus lateralis (VL) muscles. We...
Background: Diets enriched with n-3 polyunsaturated fatty acids (n-3 PUFAs) have been shown to exert a positive impact on muscle diseases.Flaxseed is one of the richest sources PUFA acid α-linolenic (ALA).The aim this study was assess effects flaxseed and ALA in models skeletal degeneration characterized by high levels Tumor Necrosis Factor-α (TNF).Methods: The vivo studies were carried out dystrophic hamsters affected damage associated TNF plasma fed long-term 30% flaxseed-supplemented...
Since the 1980's, novel functional roles of neurohypophyseal hormones vasopressin and oxytocin have emerged. Several studies investigated effects these two neurohormones on striated muscle tissues, both in vitro vivo. The skeletal myogenic cells, developing homeostasis been documented. Oxytocin appears to a greater influence cardiomyocite differentiation heart homeostasis. This review summarizes hormones, open possibility new therapeutic approaches for diseases affecting muscle.
Adult skeletal muscle is remarkably plastic. Increased contractile activity, such as endurance exercise, elicits multiple signals to activate a large set of genes, leading phenotypic changes in muscle, including IIb-to-IIa fiber type switching, enhanced mitochondrial biogenesis, and angiogenesis, match physiologic capability functional demand. Heat shock protein (Hsp) 60 which plays key role the translocation proteins from cytoplasm mitochondria. Apart its localization, Hsp60 has been...
Heat shock protein (Hsp) 60 plays a key role in the translocation of proteins and cytoprotection, is primarily localized inside mitochondrial, its levels increase skeletal muscle upon exercise (Folkesson et al., 2013). The aim this study was to examine fiber specificity HSP60 at rest after an endurance training program 45 days. Forth-eight male young (7-weeks old) healthy mice (BALB/c) were subdivided into six groups (8 per group). Three trained on rota-rod, gradually increasing duration...